ENSG00000213339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250237 ENSG00000213339 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT1 protein_coding protein_coding 65.43809 96.73354 40.99148 6.696296 2.117609 -1.238489 30.029839 60.273946 18.201830 3.7252561 0.9128353 -1.7268979 0.44059167 0.62373333 0.44436667 -0.179366667 1.451677e-12 1.451677e-12 FALSE TRUE
ENST00000587500 ENSG00000213339 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT1 protein_coding retained_intron 65.43809 96.73354 40.99148 6.696296 2.117609 -1.238489 7.699672 8.184152 4.536414 1.2874119 0.3262998 -0.8498657 0.11819167 0.08393333 0.11203333 0.028100000 4.363180e-01 1.451677e-12 FALSE FALSE
ENST00000587861 ENSG00000213339 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT1 protein_coding retained_intron 65.43809 96.73354 40.99148 6.696296 2.117609 -1.238489 4.880049 5.069850 2.261254 0.1601952 0.2890686 -1.1612967 0.07277917 0.05276667 0.05513333 0.002366667 9.522053e-01 1.451677e-12 FALSE TRUE
ENST00000589488 ENSG00000213339 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT1 protein_coding retained_intron 65.43809 96.73354 40.99148 6.696296 2.117609 -1.238489 8.626004 7.398836 5.792115 0.6867961 0.6968385 -0.3526681 0.14050000 0.07713333 0.14050000 0.063366667 5.986508e-03 1.451677e-12 TRUE TRUE
ENST00000590705 ENSG00000213339 HEK293_OSMI2_2hA HEK293_TMG_2hB QTRT1 protein_coding retained_intron 65.43809 96.73354 40.99148 6.696296 2.117609 -1.238489 6.296962 5.970827 5.533929 1.1323571 0.4478867 -0.1094362 0.10405833 0.06070000 0.13500000 0.074300000 1.579252e-04 1.451677e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000213339 E001 0.7332358 0.4738064141 4.371505e-01 5.791631e-01 19 10701375 10701429 55 + 0.321 0.148 -1.427
ENSG00000213339 E002 1.5426449 0.1361349476 1.111551e-01 2.072433e-01 19 10701430 10701438 9 + 0.573 0.252 -1.805
ENSG00000213339 E003 4.0996954 0.0780295444 2.289839e-01 3.612233e-01 19 10701439 10701448 10 + 0.774 0.576 -0.839
ENSG00000213339 E004 10.8406508 0.0996320164 6.233662e-01 7.399620e-01 19 10701449 10701449 1 + 1.015 0.982 -0.121
ENSG00000213339 E005 29.6874641 0.0034236552 8.534027e-01 9.092752e-01 19 10701450 10701453 4 + 1.392 1.407 0.054
ENSG00000213339 E006 112.7598056 0.0038186201 2.619732e-01 3.996975e-01 19 10701454 10701465 12 + 1.927 1.986 0.197
ENSG00000213339 E007 135.8333081 0.0054832687 2.071284e-01 3.350827e-01 19 10701466 10701470 5 + 2.000 2.068 0.230
ENSG00000213339 E008 501.0312586 0.0037598850 8.282247e-01 8.920512e-01 19 10701471 10701703 233 + 2.623 2.620 -0.009
ENSG00000213339 E009 357.2969453 0.0037123257 1.772226e-01 2.976168e-01 19 10701950 10702018 69 + 2.505 2.463 -0.140
ENSG00000213339 E010 38.1086539 0.0006943764 2.997861e-09 4.066851e-08 19 10702019 10702115 97 + 1.752 1.403 -1.193
ENSG00000213339 E011 298.0636888 0.0012626847 5.798904e-02 1.231832e-01 19 10702116 10702160 45 + 2.431 2.380 -0.169
ENSG00000213339 E012 425.1803537 0.0001867609 7.749767e-01 8.549941e-01 19 10702161 10702254 94 + 2.549 2.545 -0.013
ENSG00000213339 E013 3.1084217 0.0130044736 1.372981e-01 2.443123e-01 19 10706710 10706825 116 + 0.732 0.494 -1.057
ENSG00000213339 E014 264.9868533 0.0001694796 7.295045e-01 8.216799e-01 19 10707302 10707305 4 + 2.346 2.339 -0.024
ENSG00000213339 E015 452.4561775 0.0001474662 9.391190e-01 9.657654e-01 19 10707306 10707380 75 + 2.570 2.574 0.011
ENSG00000213339 E016 12.2988755 0.0121892425 1.199766e-01 2.199481e-01 19 10707466 10707499 34 + 1.169 0.996 -0.626
ENSG00000213339 E017 471.4257386 0.0001194061 5.585601e-01 6.867818e-01 19 10707500 10707615 116 + 2.582 2.594 0.043
ENSG00000213339 E018 23.5410555 0.0008348435 8.257342e-06 5.591281e-05 19 10708951 10709138 188 + 1.538 1.210 -1.140
ENSG00000213339 E019 23.6728813 0.0077220025 2.579979e-02 6.353099e-02 19 10709281 10709364 84 + 1.446 1.257 -0.659
ENSG00000213339 E020 128.8000486 0.0068956335 1.550641e-01 2.684922e-01 19 10711040 10712160 1121 + 2.091 2.016 -0.249
ENSG00000213339 E021 277.9175571 0.0001740790 9.636379e-02 1.849085e-01 19 10712161 10712162 2 + 2.392 2.353 -0.130
ENSG00000213339 E022 567.5563158 0.0001596479 5.408983e-01 6.719549e-01 19 10712163 10712299 137 + 2.680 2.671 -0.028
ENSG00000213339 E023 155.7030169 0.0008554108 1.340872e-06 1.083490e-05 19 10712300 10712552 253 + 2.234 2.075 -0.532
ENSG00000213339 E024 242.7832505 0.0001930242 2.907422e-01 4.315382e-01 19 10712553 10712562 10 + 2.280 2.311 0.102
ENSG00000213339 E025 389.5559252 0.0001658174 5.179626e-02 1.123551e-01 19 10712563 10712628 66 + 2.475 2.519 0.146
ENSG00000213339 E026 28.9828847 0.0008510704 4.024375e-03 1.321007e-02 19 10712663 10712757 95 + 1.538 1.339 -0.688
ENSG00000213339 E027 508.7592081 0.0002225101 3.796910e-02 8.729000e-02 19 10712758 10712867 110 + 2.593 2.635 0.140
ENSG00000213339 E028 5.7463461 0.0274548506 3.531562e-01 4.974007e-01 19 10712918 10712952 35 + 0.633 0.793 0.658
ENSG00000213339 E029 437.8396231 0.0019586977 2.922358e-02 7.043754e-02 19 10712953 10713040 88 + 2.509 2.577 0.228
ENSG00000213339 E030 220.8654943 0.0031396806 1.675603e-01 2.850127e-01 19 10713118 10713123 6 + 2.222 2.280 0.196
ENSG00000213339 E031 344.3255532 0.0039064653 5.939867e-02 1.256086e-01 19 10713124 10713197 74 + 2.399 2.476 0.256
ENSG00000213339 E032 244.6147237 0.0030362494 4.871278e-02 1.068780e-01 19 10713198 10713365 168 + 2.249 2.329 0.266
ENSG00000213339 E033 9.3186852 0.0093588234 8.753485e-01 9.239537e-01 19 10713369 10713594 226 + 0.939 0.923 -0.063
ENSG00000213339 E034 1.1728179 0.0111100804 3.374436e-01 4.813433e-01 19 10716026 10716096 71 + 0.423 0.248 -1.098