ENSG00000213047

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235453 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding protein_coding 1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.02977689 0.02778822 0.03878655 0.018508846 0.03878655 0.3685467 0.03542083 0.09596667 0.01633333 -0.07963333 0.3349818 0.0173147 FALSE TRUE
ENST00000294737 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding nonsense_mediated_decay 1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.03962076 0.00000000 0.13771967 0.000000000 0.13771967 3.8847900 0.01528333 0.00000000 0.05643333 0.05643333 1.0000000 0.0173147 FALSE TRUE
ENST00000468589 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding retained_intron 1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.08169569 0.10839926 0.11850694 0.048457074 0.03820974 0.1181862 0.08864167 0.32996667 0.04783333 -0.28213333 0.0173147 0.0173147   FALSE
ENST00000495550 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding retained_intron 1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.12380248 0.00000000 0.21580880 0.000000000 0.01860833 4.4970298 0.11742500 0.00000000 0.08686667 0.08686667 0.1707801 0.0173147 FALSE TRUE
ENST00000620048 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding protein_coding 1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.61437365 0.15258443 1.15383431 0.008627518 0.09240243 2.8396246 0.46272083 0.48523333 0.46513333 -0.02010000 0.9916025 0.0173147 FALSE TRUE
MSTRG.2792.2 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding   1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.12203738 0.00000000 0.22651443 0.000000000 0.11333776 4.5638563 0.06064583 0.00000000 0.08966667 0.08966667 0.6538695 0.0173147 FALSE TRUE
MSTRG.2792.4 ENSG00000213047 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND1B protein_coding   1.420653 0.3160953 2.502121 0.0213144 0.09688617 2.94554 0.34125276 0.02732336 0.54584675 0.027323361 0.22395375 3.8965364 0.15331667 0.08880000 0.21220000 0.12340000 0.4431700 0.0173147 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000213047 E001 53.1825856 0.0007678084 5.085883e-04 0.0021917771 1 197504748 197507597 2850 - 1.542 1.747 0.698
ENSG00000213047 E002 36.5399198 0.0008771259 1.463733e-04 0.0007314495 1 197507598 197509643 2046 - 1.457 1.097 -1.264
ENSG00000213047 E003 25.9581119 0.0008108879 3.319018e-01 0.4755364670 1 197509644 197510824 1181 - 1.291 1.205 -0.301
ENSG00000213047 E004 9.9215695 0.0276466547 2.836306e-01 0.4237787344 1 197510825 197510972 148 - 0.865 1.033 0.628
ENSG00000213047 E005 12.2175448 0.0032890233 5.170561e-01 0.6515286573 1 197511728 197511944 217 - 0.988 0.908 -0.302
ENSG00000213047 E006 7.3471398 0.0023715056 1.564783e-01 0.2704233829 1 197512871 197512953 83 - 0.813 0.563 -1.051
ENSG00000213047 E007 8.4323600 0.0276130455 5.021285e-01 0.6382221887 1 197539964 197540071 108 - 0.851 0.735 -0.459
ENSG00000213047 E008 7.1476774 0.0089945136 4.383341e-01 0.5802240001 1 197540959 197541015 57 - 0.788 0.658 -0.536
ENSG00000213047 E009 0.0000000       1 197545567 197545921 355 -      
ENSG00000213047 E010 7.5872344 0.0034579352 3.438124e-01 0.4878711769 1 197545922 197545990 69 - 0.813 0.657 -0.635
ENSG00000213047 E011 5.7164502 0.0140444200 4.082453e-01 0.5518433922 1 197546733 197546773 41 - 0.715 0.563 -0.656
ENSG00000213047 E012 0.5546650 0.0217782001 2.569907e-02 0.0633175242 1 197552255 197553021 767 - 0.049 0.443 3.890
ENSG00000213047 E013 6.3214797 0.0026401252 5.888499e-01 0.7120141394 1 197553022 197553112 91 - 0.744 0.657 -0.360
ENSG00000213047 E014 6.2256273 0.0027886704 9.838894e-02 0.1880649062 1 197583152 197583253 102 - 0.762 0.442 -1.435
ENSG00000213047 E015 6.9297314 0.0024401597 4.511736e-01 0.5921504760 1 197595208 197595333 126 - 0.780 0.657 -0.505
ENSG00000213047 E016 1.0308569 0.0209341515 4.086075e-01 0.5522187417 1 197605482 197607072 1591 - 0.264 0.000 -10.355
ENSG00000213047 E017 5.6148599 0.0389884884 2.035746e-01 0.3306861690 1 197607073 197607174 102 - 0.716 0.443 -1.240
ENSG00000213047 E018 4.8303281 0.0090375525 2.702195e-01 0.4088186500 1 197611931 197611976 46 - 0.662 0.443 -1.020
ENSG00000213047 E019 5.1406320 0.0670950173 5.982877e-01 0.7199174539 1 197617659 197617759 101 - 0.674 0.562 -0.490
ENSG00000213047 E020 3.5789564 0.0714431264 5.839773e-01 0.7079816503 1 197642711 197642772 62 - 0.561 0.440 -0.588
ENSG00000213047 E021 3.2663605 0.0055766462 8.369859e-01 0.8980464271 1 197642773 197642821 49 - 0.515 0.563 0.223
ENSG00000213047 E022 5.0314854 0.0035934871 9.957875e-01 1.0000000000 1 197645690 197645743 54 - 0.650 0.657 0.030
ENSG00000213047 E023 0.4375944 0.0263116412 1.000000e+00 1.0000000000 1 197647055 197647114 60 - 0.133 0.000 -9.314
ENSG00000213047 E024 4.7189914 0.0069542051 6.669206e-01 0.7742886810 1 197652235 197652315 81 - 0.638 0.563 -0.334
ENSG00000213047 E025 3.8752657 0.0049286230 4.613885e-01 0.6013627447 1 197658300 197658369 70 - 0.588 0.443 -0.698
ENSG00000213047 E026 7.0913740 0.0024105632 5.326310e-01 0.6649642563 1 197672037 197672156 120 - 0.753 0.857 0.410
ENSG00000213047 E027 5.2153930 0.0032585552 6.549002e-01 0.7649412705 1 197674120 197674169 50 - 0.650 0.735 0.352
ENSG00000213047 E028 5.2620307 0.0223883604 5.232444e-01 0.6569684591 1 197715031 197715074 44 - 0.684 0.563 -0.525
ENSG00000213047 E029 4.0544842 0.0861354194 8.517163e-05 0.0004525074 1 197734009 197735249 1241 - 0.386 1.117 3.075
ENSG00000213047 E030 0.4407149 0.0216917690 3.031351e-01 0.4450336427 1 197735250 197735305 56 - 0.093 0.275 1.886
ENSG00000213047 E031 2.6592772 0.0061026824 2.715827e-03 0.0094204127 1 197735306 197735585 280 - 0.342 0.857 2.372
ENSG00000213047 E032 2.8044630 0.0151779319 4.744142e-03 0.0152165157 1 197735586 197735657 72 - 0.365 0.856 2.233
ENSG00000213047 E033 2.8648173 0.0304155933 3.445887e-02 0.0806370046 1 197735658 197735796 139 - 0.407 0.798 1.765
ENSG00000213047 E034 5.0290329 0.0544800964 8.109241e-02 0.1612561637 1 197772868 197772932 65 - 0.693 0.276 -2.152
ENSG00000213047 E035 0.0000000       1 197774487 197774607 121 -      
ENSG00000213047 E036 3.9324094 0.0219518828 9.373223e-01 0.9646244537 1 197775139 197775351 213 - 0.574 0.563 -0.049
ENSG00000213047 E037 0.1451727 0.0436456017 7.576467e-01   1 197775352 197775539 188 - 0.049 0.000 -7.809
ENSG00000213047 E038 0.0000000       1 197775540 197775696 157 -