ENSG00000206560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399451 ENSG00000206560 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD28 protein_coding protein_coding 11.22037 3.513081 18.01269 0.2254073 1.099577 2.354905 4.0895452 0.54048478 8.821022 0.17582293 0.3236550 4.003806 0.3200125 0.1509333 0.4954667 0.3445333 3.267280e-04 5.438494e-24 FALSE TRUE
ENST00000497037 ENSG00000206560 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD28 protein_coding processed_transcript 11.22037 3.513081 18.01269 0.2254073 1.099577 2.354905 1.5830348 0.00000000 2.484276 0.00000000 0.2535293 7.962477 0.0855125 0.0000000 0.1373000 0.1373000 6.237706e-13 5.438494e-24 FALSE TRUE
ENST00000498713 ENSG00000206560 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD28 protein_coding processed_transcript 11.22037 3.513081 18.01269 0.2254073 1.099577 2.354905 1.8807085 0.00000000 2.722170 0.00000000 0.6299816 8.093903 0.1377542 0.0000000 0.1490667 0.1490667 2.432812e-07 5.438494e-24 FALSE TRUE
ENST00000624145 ENSG00000206560 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD28 protein_coding protein_coding 11.22037 3.513081 18.01269 0.2254073 1.099577 2.354905 1.9209757 2.74067038 0.000000 0.18440107 0.0000000 -8.103639 0.3240583 0.7854000 0.0000000 -0.7854000 5.438494e-24 5.438494e-24 FALSE TRUE
MSTRG.22558.6 ENSG00000206560 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD28 protein_coding   11.22037 3.513081 18.01269 0.2254073 1.099577 2.354905 0.8462147 0.05564477 1.804819 0.03206791 0.2737662 4.789002 0.0529375 0.0165000 0.1027000 0.0862000 3.780406e-03 5.438494e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000206560 E001 0.5963950 0.4090499509 1.098464e-01 2.053410e-01 3 15667236 15667238 3 - 0.068 0.446 3.403
ENSG00000206560 E002 69.0174174 0.0203954205 1.009383e-08 1.243252e-07 3 15667239 15667745 507 - 1.611 2.085 1.599
ENSG00000206560 E003 91.6833795 0.0091081596 2.802334e-04 1.299268e-03 3 15667746 15668305 560 - 1.835 2.063 0.768
ENSG00000206560 E004 290.3703889 0.0001737756 2.268845e-36 6.036881e-34 3 15668306 15669740 1435 - 2.311 2.590 0.931
ENSG00000206560 E005 36.3184168 0.0005611040 4.103668e-03 1.343496e-02 3 15669741 15669791 51 - 1.450 1.640 0.653
ENSG00000206560 E006 106.2458121 0.0049659621 5.347178e-03 1.687668e-02 3 15669792 15670109 318 - 1.923 2.070 0.494
ENSG00000206560 E007 186.4559806 0.0005447375 3.351858e-01 4.789592e-01 3 15670110 15670556 447 - 2.198 2.237 0.129
ENSG00000206560 E008 60.5537327 0.0004421834 5.595231e-01 6.876267e-01 3 15675898 15675989 92 - 1.716 1.755 0.133
ENSG00000206560 E009 4.7253367 0.0042624389 1.677547e-04 8.255137e-04 3 15675990 15676223 234 - 0.806 0.000 -15.350
ENSG00000206560 E010 2.6185689 0.0058463533 2.987863e-01 4.402561e-01 3 15676596 15676973 378 - 0.548 0.353 -1.011
ENSG00000206560 E011 62.9494153 0.0004781348 4.395516e-01 5.813042e-01 3 15676974 15677056 83 - 1.725 1.774 0.164
ENSG00000206560 E012 48.3963063 0.0055312440 9.398499e-01 9.662284e-01 3 15677480 15677535 56 - 1.621 1.636 0.051
ENSG00000206560 E013 38.1216449 0.0056420245 9.592695e-01 9.784579e-01 3 15677536 15677562 27 - 1.523 1.536 0.043
ENSG00000206560 E014 0.6600969 0.0577891598 2.253418e-01 3.568172e-01 3 15677563 15677606 44 - 0.126 0.354 1.898
ENSG00000206560 E015 79.7508931 0.0010589838 8.054886e-01 8.763297e-01 3 15678209 15678354 146 - 1.841 1.838 -0.010
ENSG00000206560 E016 64.5430634 0.0021099063 3.158318e-01 4.585988e-01 3 15679301 15679384 84 - 1.762 1.715 -0.160
ENSG00000206560 E017 60.3649703 0.0019652687 6.211780e-05 3.418951e-04 3 15679476 15679563 88 - 1.774 1.534 -0.813
ENSG00000206560 E018 2.4432072 0.0061784397 9.373512e-02 1.809605e-01 3 15683742 15685225 1484 - 0.548 0.212 -2.011
ENSG00000206560 E019 102.6804206 0.0066480047 2.859194e-03 9.850672e-03 3 15685226 15685445 220 - 1.986 1.818 -0.563
ENSG00000206560 E020 76.5830874 0.0056268917 1.690493e-02 4.472513e-02 3 15686002 15686119 118 - 1.854 1.716 -0.468
ENSG00000206560 E021 0.1482932 0.0418263183 1.214487e-01   3 15686120 15686221 102 - 0.000 0.211 11.669
ENSG00000206560 E022 64.2080493 0.0017995684 1.214648e-01 2.220205e-01 3 15686222 15686309 88 - 1.766 1.688 -0.264
ENSG00000206560 E023 0.2924217 0.0290785164 1.000000e+00   3 15686310 15686453 144 - 0.126 0.000 -11.392
ENSG00000206560 E024 0.0000000       3 15689840 15690018 179 -      
ENSG00000206560 E025 87.4386952 0.0011087364 4.519942e-02 1.005613e-01 3 15690019 15690220 202 - 1.900 1.813 -0.292
ENSG00000206560 E026 54.3232563 0.0042054386 6.132227e-02 1.288562e-01 3 15694739 15694813 75 - 1.703 1.588 -0.392
ENSG00000206560 E027 36.5561944 0.0006824404 3.216878e-02 7.618039e-02 3 15695188 15695214 27 - 1.541 1.395 -0.500
ENSG00000206560 E028 55.6868759 0.0004008367 3.948634e-02 9.008174e-02 3 15696134 15696245 112 - 1.711 1.601 -0.374
ENSG00000206560 E029 49.9938402 0.0004927913 7.539053e-01 8.396734e-01 3 15707924 15708064 141 - 1.644 1.634 -0.032
ENSG00000206560 E030 31.5015652 0.0006101842 2.914320e-01 4.323004e-01 3 15709668 15709736 69 - 1.465 1.395 -0.240
ENSG00000206560 E031 28.9121215 0.0007161152 2.726832e-02 6.653573e-02 3 15711211 15711274 64 - 1.452 1.283 -0.587
ENSG00000206560 E032 34.8457559 0.0005975803 2.615138e-01 3.991573e-01 3 15712140 15712222 83 - 1.508 1.437 -0.243
ENSG00000206560 E033 47.2788237 0.0004754481 2.944399e-02 7.086337e-02 3 15713527 15713641 115 - 1.647 1.519 -0.438
ENSG00000206560 E034 41.1794257 0.0056174464 6.109894e-02 1.284840e-01 3 15714578 15714656 79 - 1.591 1.457 -0.460
ENSG00000206560 E035 69.0953931 0.0137275246 3.314352e-03 1.118981e-02 3 15720915 15721100 186 - 1.827 1.601 -0.768
ENSG00000206560 E036 37.8336329 0.0045075323 3.913480e-02 8.943542e-02 3 15721101 15721127 27 - 1.558 1.406 -0.519
ENSG00000206560 E037 30.7396320 0.0083838806 2.664487e-02 6.525356e-02 3 15724382 15724396 15 - 1.478 1.284 -0.673
ENSG00000206560 E038 64.0795857 0.0032153102 5.191700e-02 1.125784e-01 3 15724397 15724524 128 - 1.772 1.665 -0.365
ENSG00000206560 E039 49.0243079 0.0005805175 2.573580e-01 3.944605e-01 3 15735410 15735497 88 - 1.647 1.587 -0.203
ENSG00000206560 E040 24.4330372 0.0014057424 9.342589e-01 9.625595e-01 3 15737033 15737038 6 - 1.334 1.349 0.053
ENSG00000206560 E041 65.9900013 0.0004060829 1.829751e-05 1.145201e-04 3 15737039 15737233 195 - 1.806 1.573 -0.789
ENSG00000206560 E042 38.6436156 0.0008024744 1.223522e-04 6.245928e-04 3 15751750 15751820 71 - 1.589 1.311 -0.958
ENSG00000206560 E043 0.0000000       3 15756480 15756483 4 -      
ENSG00000206560 E044 0.0000000       3 15756484 15756548 65 -      
ENSG00000206560 E045 36.8232049 0.0033276065 3.169772e-03 1.076596e-02 3 15766234 15766312 79 - 1.560 1.337 -0.768
ENSG00000206560 E046 0.0000000       3 15781437 15781655 219 -      
ENSG00000206560 E047 33.1160052 0.0099361897 1.646113e-03 6.108262e-03 3 15795223 15795306 84 - 1.524 1.239 -0.988
ENSG00000206560 E048 0.0000000       3 15796396 15796404 9 -      
ENSG00000206560 E049 1.3412746 0.0119172857 4.190081e-01 5.622637e-01 3 15796405 15797970 1566 - 0.371 0.211 -1.106
ENSG00000206560 E050 0.1515154 0.0427051595 1.000000e+00   3 15797971 15798184 214 - 0.068 0.000 -10.259
ENSG00000206560 E051 7.1892035 0.0023885181 4.438998e-01 5.854804e-01 3 15814240 15814309 70 - 0.880 0.780 -0.390
ENSG00000206560 E052 27.3012365 0.0007267731 5.403200e-06 3.816914e-05 3 15859377 15859771 395 - 1.460 1.043 -1.471