ENSG00000206417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000511998 ENSG00000206417 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 2.928094 3.878577 1.848577 0.1053955 0.08205951 -1.065044 1.387765 2.131477 0.5042609 0.18472373 0.07403769 -2.0580337 0.4497042 0.5477333 0.2753333 -0.2724000 0.004070524 0.004070524 FALSE FALSE
MSTRG.23669.1 ENSG00000206417 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA   2.928094 3.878577 1.848577 0.1053955 0.08205951 -1.065044 1.495148 1.689256 1.2948787 0.08251239 0.12729152 -0.3809879 0.5301083 0.4374000 0.6980667 0.2606667 0.007915461 0.004070524 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000206417 E001 113.648613 0.0005550425 0.2010295021 0.3274563510 3 129314776 129315391 616 + 2.061 2.016 -0.149
ENSG00000206417 E002 104.164302 0.0003372523 0.6951863564 0.7958230575 3 129315392 129315519 128 + 2.004 1.985 -0.063
ENSG00000206417 E003 34.852789 0.0108359771 0.0433480928 0.0971980510 3 129315520 129315638 119 + 1.621 1.462 -0.544
ENSG00000206417 E004 3.508529 0.0046910739 0.0023577939 0.0083318159 3 129315639 129315805 167 + 0.879 0.430 -1.958
ENSG00000206417 E005 9.168396 0.0779676358 0.3533928482 0.4976378827 3 129315806 129315903 98 + 1.061 0.917 -0.533
ENSG00000206417 E006 15.637895 0.0013508828 0.0018279000 0.0066896585 3 129317154 129317345 192 + 0.970 1.265 1.063
ENSG00000206417 E007 25.884965 0.0008853044 0.0002154914 0.0010304455 3 129317932 129318105 174 + 1.201 1.473 0.947
ENSG00000206417 E008 18.207241 0.0012031437 0.0002278552 0.0010826810 3 129318106 129318235 130 + 1.009 1.338 1.174
ENSG00000206417 E009 13.111661 0.0019274298 0.0011204983 0.0043721175 3 129318236 129318310 75 + 0.853 1.197 1.265
ENSG00000206417 E010 0.699736 0.0166240240 0.1212968251 0.2217738537 3 129318311 129318311 1 + 0.001 0.294 9.643
ENSG00000206417 E011 14.220803 0.0013083416 0.0011505654 0.0044732222 3 129318543 129318637 95 + 0.904 1.229 1.185
ENSG00000206417 E012 8.425882 0.0020643288 0.0001052239 0.0005461767 3 129323350 129323604 255 + 1.189 0.766 -1.582
ENSG00000206417 E013 3.715111 0.1072191190 0.1372271601 0.2442206847 3 129323890 129323997 108 + 0.825 0.534 -1.232
ENSG00000206417 E014 16.295629 0.0011937283 0.0100643649 0.0289182008 3 129324181 129326225 2045 + 1.343 1.125 -0.772