ENSG00000206149

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524476 ENSG00000206149 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P9 transcribed_unprocessed_pseudogene retained_intron 8.126507 6.665116 7.998269 0.4935348 0.1871178 0.2626976 0.4530448 0.1105687 0.2668384 0.01651967 0.04012976 1.1991894 0.05282083 0.01656667 0.03363333 0.01706667 3.108129e-01 4.554631e-08 TRUE TRUE
ENST00000528584 ENSG00000206149 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P9 transcribed_unprocessed_pseudogene processed_transcript 8.126507 6.665116 7.998269 0.4935348 0.1871178 0.2626976 2.0514923 2.0489003 1.4755674 0.27092589 0.06733799 -0.4708599 0.25694167 0.31186667 0.18500000 -0.12686667 1.340058e-01 4.554631e-08 TRUE TRUE
ENST00000529537 ENSG00000206149 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P9 transcribed_unprocessed_pseudogene processed_transcript 8.126507 6.665116 7.998269 0.4935348 0.1871178 0.2626976 0.3064120 0.0000000 0.4466827 0.00000000 0.44668274 5.5131204 0.03291250 0.00000000 0.05366667 0.05366667 8.588475e-01 4.554631e-08   FALSE
ENST00000569226 ENSG00000206149 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P9 transcribed_unprocessed_pseudogene retained_intron 8.126507 6.665116 7.998269 0.4935348 0.1871178 0.2626976 1.8100112 1.1168454 2.1903499 0.36837468 0.09034798 0.9654434 0.21430833 0.16566667 0.27403333 0.10836667 2.709382e-01 4.554631e-08   FALSE
ENST00000689854 ENSG00000206149 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2P9 transcribed_unprocessed_pseudogene processed_transcript 8.126507 6.665116 7.998269 0.4935348 0.1871178 0.2626976 1.2314206 2.2066908 0.8658141 0.13418232 0.06121810 -1.3397110 0.16894167 0.33383333 0.10850000 -0.22533333 4.554631e-08 4.554631e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000206149 E001 0.0000000       15 28589434 28589439 6 +      
ENSG00000206149 E002 0.0000000       15 28589440 28589450 11 +      
ENSG00000206149 E003 0.3289534 0.0286539337 7.948633e-01   15 28589451 28589475 25 + 0.099 0.150 0.693
ENSG00000206149 E004 0.6986918 0.0166828301 1.748617e-01 0.2945017679 15 28589476 28589484 9 + 0.099 0.351 2.278
ENSG00000206149 E005 0.6986918 0.0166828301 1.748617e-01 0.2945017679 15 28589485 28589487 3 + 0.099 0.351 2.278
ENSG00000206149 E006 0.6986918 0.0166828301 1.748617e-01 0.2945017679 15 28589488 28589491 4 + 0.099 0.351 2.278
ENSG00000206149 E007 1.9499748 0.0076336711 9.731335e-01 0.9872348676 15 28589492 28589548 57 + 0.446 0.487 0.207
ENSG00000206149 E008 3.0269273 0.0050029072 7.000007e-01 0.7995866259 15 28590158 28590188 31 + 0.610 0.591 -0.086
ENSG00000206149 E009 5.6005574 0.0137371850 1.152905e-01 0.2132778647 15 28590189 28590260 72 + 0.884 0.710 -0.687
ENSG00000206149 E010 0.0000000       15 28590261 28591123 863 +      
ENSG00000206149 E011 6.6127067 0.0096572242 4.865354e-02 0.1067753271 15 28591157 28591795 639 + 0.729 1.022 1.127
ENSG00000206149 E012 0.1817044 0.0403100149 3.473000e-01   15 28593929 28594196 268 + 0.000 0.150 11.333
ENSG00000206149 E013 0.5085815 0.2636978916 4.466790e-01 0.5881591896 15 28600170 28600297 128 + 0.099 0.263 1.702
ENSG00000206149 E014 6.6139490 0.0074043250 3.926076e-02 0.0896480861 15 28612059 28612173 115 + 0.963 0.744 -0.850
ENSG00000206149 E015 10.6061282 0.0017005665 2.929994e-02 0.0705856677 15 28618219 28618378 160 + 1.124 0.947 -0.645
ENSG00000206149 E016 8.3111902 0.0020783020 6.569785e-02 0.1362043560 15 28618524 28618655 132 + 1.020 0.858 -0.610
ENSG00000206149 E017 5.0749366 0.0091056285 4.881409e-02 0.1070512936 15 28629266 28629441 176 + 0.869 0.634 -0.952
ENSG00000206149 E018 0.7718584 0.0164725584 9.572252e-01 0.9771975497 15 28632637 28632651 15 + 0.247 0.262 0.106
ENSG00000206149 E019 3.2054981 0.0049711773 5.723941e-01 0.6985133262 15 28632652 28632807 156 + 0.636 0.591 -0.201
ENSG00000206149 E020 0.0000000       15 28633123 28633124 2 +      
ENSG00000206149 E021 0.0000000       15 28633125 28633191 67 +      
ENSG00000206149 E022 5.2841757 0.0032015578 7.522444e-02 0.1518912546 15 28633192 28633295 104 + 0.869 0.674 -0.782
ENSG00000206149 E023 8.9068426 0.0501274428 1.449958e-01 0.2548288061 15 28633590 28633740 151 + 1.041 0.889 -0.567
ENSG00000206149 E024 0.0000000       15 28633741 28634444 704 +      
ENSG00000206149 E025 3.6216373 0.5024182157 2.760763e-01 0.4154829931 15 28636487 28636701 215 + 0.728 0.518 -0.924
ENSG00000206149 E026 0.0000000       15 28636702 28636974 273 +      
ENSG00000206149 E027 2.6000307 0.0169066685 4.270089e-01 0.5698475520 15 28636975 28637107 133 + 0.582 0.487 -0.444
ENSG00000206149 E028 6.7861611 0.0025477613 1.737784e-01 0.2930940793 15 28637215 28637342 128 + 0.926 0.805 -0.464
ENSG00000206149 E029 8.2620098 0.0022474819 2.520836e-01 0.3884030590 15 28637435 28637630 196 + 0.987 0.905 -0.307
ENSG00000206149 E030 0.9275265 0.0144990133 6.958196e-01 0.7963174979 15 28640259 28640392 134 + 0.306 0.262 -0.309
ENSG00000206149 E031 0.9286724 0.0143486520 2.016584e-01 0.3282432650 15 28640922 28641092 171 + 0.358 0.150 -1.630
ENSG00000206149 E032 0.1482932 0.0416890719 3.487886e-01   15 28641093 28641169 77 + 0.000 0.150 11.327
ENSG00000206149 E033 1.4403743 0.0693020446 8.502202e-01 0.9070984996 15 28641170 28641226 57 + 0.358 0.424 0.367
ENSG00000206149 E034 2.8399505 0.0820296093 8.556550e-01 0.9107478523 15 28641227 28641312 86 + 0.582 0.589 0.033
ENSG00000206149 E035 2.9873013 0.2969171417 2.856245e-01 0.4259824638 15 28641430 28641581 152 + 0.662 0.490 -0.781
ENSG00000206149 E036 7.7693360 0.0084933829 1.014792e-01 0.1927206101 15 28642373 28642564 192 + 0.987 0.833 -0.584
ENSG00000206149 E037 9.6055632 0.0019122061 1.948974e-02 0.0503904519 15 28648880 28649067 188 + 1.089 0.882 -0.766
ENSG00000206149 E038 5.1784905 0.0641103748 3.863064e-01 0.5304999562 15 28650507 28650699 193 + 0.821 0.716 -0.420
ENSG00000206149 E039 1.9478734 0.0389140570 2.722479e-01 0.4111127082 15 28651405 28651420 16 + 0.519 0.352 -0.883
ENSG00000206149 E040 9.5995446 0.0389269551 1.169851e-01 0.2156595879 15 28651421 28651555 135 + 1.079 0.910 -0.625
ENSG00000206149 E041 2.4982866 0.0066769775 1.800694e-01 0.3012611105 15 28651556 28651587 32 + 0.610 0.424 -0.892
ENSG00000206149 E042 14.2139829 0.0127625681 5.543216e-02 0.1187302812 15 28654274 28654441 168 + 1.233 1.086 -0.526
ENSG00000206149 E043 4.9560495 0.0260312955 7.978491e-01 0.8710037598 15 28654442 28654455 14 + 0.768 0.775 0.027
ENSG00000206149 E044 13.0132397 0.0205608437 2.401328e-01 0.3742945407 15 28655273 28655420 148 + 1.179 1.098 -0.290
ENSG00000206149 E045 1.4413934 0.0096943335 6.312348e-01 0.7462901272 15 28655421 28655494 74 + 0.404 0.350 -0.308
ENSG00000206149 E046 2.2457049 0.0611899064 8.432884e-01 0.9024117090 15 28655495 28655691 197 + 0.484 0.492 0.040
ENSG00000206149 E047 16.7090677 0.0011702798 7.228253e-05 0.0003912488 15 28655796 28656026 231 + 1.347 1.055 -1.039
ENSG00000206149 E048 7.7458129 0.0048556333 2.735576e-01 0.4126036062 15 28657187 28657325 139 + 0.963 0.882 -0.306
ENSG00000206149 E049 8.6619240 0.0020709659 6.085957e-01 0.7282926078 15 28658623 28658766 144 + 0.975 0.968 -0.029
ENSG00000206149 E050 8.2169427 0.0021598304 6.463807e-01 0.7583126635 15 28663378 28663520 143 + 0.951 0.948 -0.013
ENSG00000206149 E051 6.8010471 0.0637604123 8.656381e-01 0.9174557593 15 28667196 28667463 268 + 0.870 0.889 0.074
ENSG00000206149 E052 11.6117618 0.0708815946 3.788095e-01 0.5231016449 15 28667561 28667697 137 + 1.115 1.051 -0.233
ENSG00000206149 E053 8.5619332 0.0862359813 2.517035e-01 0.3879782985 15 28668257 28668355 99 + 1.021 0.891 -0.483
ENSG00000206149 E054 5.5671407 0.0030371597 6.244042e-01 0.7407153432 15 28671460 28671633 174 + 0.749 0.858 0.431
ENSG00000206149 E055 1.9542387 0.0075627746 3.619470e-02 0.0839554502 15 28671731 28671834 104 + 0.248 0.635 2.109
ENSG00000206149 E056 1.6565209 0.0102398096 2.381297e-01 0.3719686750 15 28671835 28671856 22 + 0.306 0.542 1.277
ENSG00000206149 E057 0.4782907 0.0241572738 4.238693e-02 0.0954234751 15 28673672 28673781 110 + 0.000 0.350 12.799
ENSG00000206149 E058 6.8905254 0.0505694861 4.780546e-02 0.1052738085 15 28673888 28674027 140 + 0.685 1.048 1.406
ENSG00000206149 E059 7.8348889 0.0288891111 1.829501e-02 0.0477756933 15 28681796 28681843 48 + 0.729 1.104 1.427
ENSG00000206149 E060 5.4251068 0.0910986342 2.941105e-01 0.4351907879 15 28681844 28682178 335 + 0.854 0.715 -0.556
ENSG00000206149 E061 35.8047660 0.0007175794 2.117622e-04 0.0010142772 15 28684129 28684391 263 + 1.425 1.687 0.894
ENSG00000206149 E062 96.1763578 0.0293976045 3.242975e-04 0.0014780729 15 28684392 28685264 873 + 1.817 2.137 1.075