ENSG00000205903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382252 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding protein_coding 17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 6.612457 8.7345098 5.4981923 1.46763271 0.4021840 -0.6667986 0.36489583 0.41776667 0.36653333 -0.051233333 0.4005818202 0.0002245885 FALSE TRUE
ENST00000427912 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding protein_coding 17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 2.166110 3.3379061 2.1922647 1.67594619 1.5340451 -0.6042712 0.12219583 0.14196667 0.13440000 -0.007566667 0.9831011980 0.0002245885   FALSE
ENST00000614588 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding retained_intron 17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 1.351273 0.5198466 1.3448285 0.06953219 0.1999495 1.3544636 0.07993333 0.02526667 0.09093333 0.065666667 0.0002245885 0.0002245885 FALSE FALSE
MSTRG.29475.2 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding   17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 1.865235 3.2603346 0.7367103 0.56206467 0.7367103 -2.1308177 0.10924167 0.17293333 0.04873333 -0.124200000 0.1486471387 0.0002245885 FALSE TRUE
MSTRG.29475.7 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding   17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 3.892353 3.1269334 3.6496008 0.57360273 0.5435203 0.2223314 0.23444167 0.15600000 0.24980000 0.093800000 0.4435820599 0.0002245885 FALSE FALSE
MSTRG.29475.8 ENSG00000205903 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF316 protein_coding   17.454 20.69457 15.0129 2.83074 0.9948171 -0.462786 1.431301 1.6564668 1.2317969 0.02917478 0.3435315 -0.4243634 0.08082917 0.08360000 0.08493333 0.001333333 0.9896971117 0.0002245885 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205903 E001 0.8041237 0.0159386803 8.748877e-01 9.236063e-01 7 6637318 6637328 11 + 0.261 0.248 -0.095
ENSG00000205903 E002 4.1865237 0.1063419314 4.436712e-03 1.436249e-02 7 6637329 6637347 19 + 0.967 0.446 -2.205
ENSG00000205903 E003 4.3316964 0.0636107950 9.596360e-04 3.820535e-03 7 6637348 6637349 2 + 0.985 0.446 -2.271
ENSG00000205903 E004 6.0311830 0.1147006805 7.478491e-04 3.071092e-03 7 6637350 6637364 15 + 1.127 0.520 -2.424
ENSG00000205903 E005 19.2134272 0.0568950582 3.619417e-02 8.395526e-02 7 6637365 6637447 83 + 1.418 1.184 -0.819
ENSG00000205903 E006 7.7553753 0.0119810159 1.348271e-03 5.137182e-03 7 6637772 6637845 74 + 1.112 0.752 -1.360
ENSG00000205903 E007 17.5520430 0.0386843591 7.512256e-02 1.517292e-01 7 6637846 6637855 10 + 1.342 1.175 -0.589
ENSG00000205903 E008 54.4594928 0.0004504101 1.626341e-03 6.045431e-03 7 6637856 6637965 110 + 1.789 1.670 -0.402
ENSG00000205903 E009 55.1383758 0.0012020813 4.407609e-02 9.852256e-02 7 6637966 6638009 44 + 1.765 1.698 -0.226
ENSG00000205903 E010 109.5005131 0.0003229510 4.166612e-04 1.838268e-03 7 6639042 6639141 100 + 2.070 1.982 -0.295
ENSG00000205903 E011 101.9232973 0.0002912966 7.107134e-02 1.451186e-01 7 6641825 6641871 47 + 2.005 1.974 -0.103
ENSG00000205903 E012 95.8750943 0.0004424582 1.948479e-01 3.198176e-01 7 6641872 6641884 13 + 1.968 1.953 -0.048
ENSG00000205903 E013 137.5665073 0.0072072447 3.857180e-01 5.299032e-01 7 6641885 6641962 78 + 2.121 2.114 -0.023
ENSG00000205903 E014 7.7744206 0.0043325425 1.619495e-06 1.285186e-05 7 6641963 6641990 28 + 1.188 0.663 -2.000
ENSG00000205903 E015 15.1883089 0.0011694898 4.326688e-08 4.726276e-07 7 6641991 6642381 391 + 1.417 0.977 -1.564
ENSG00000205903 E016 131.5370139 0.0019643674 8.327851e-01 8.952377e-01 7 6642382 6642529 148 + 2.078 2.106 0.095
ENSG00000205903 E017 77.1520207 0.0003912505 3.413984e-02 8.003180e-02 7 6642530 6642673 144 + 1.901 1.848 -0.179
ENSG00000205903 E018 130.9630321 0.0004880116 8.862079e-01 9.312239e-01 7 6642674 6642764 91 + 2.065 2.105 0.134
ENSG00000205903 E019 175.4560960 0.0003929750 6.403797e-01 7.536263e-01 7 6642964 6643073 110 + 2.204 2.226 0.073
ENSG00000205903 E020 223.6222268 0.0002642266 1.203400e-01 2.204683e-01 7 6643822 6643948 127 + 2.323 2.320 -0.011
ENSG00000205903 E021 210.1062345 0.0003068718 5.635592e-04 2.397642e-03 7 6644480 6644593 114 + 2.328 2.276 -0.177
ENSG00000205903 E022 1844.1395135 0.0015354142 5.454787e-10 8.494805e-09 7 6652303 6658279 5977 + 3.167 3.276 0.364