ENSG00000205758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381554 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding protein_coding 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 2.607349 1.5807953 4.3272889 0.2906460 0.15269643 1.447045 0.12533333 0.20290000 0.11630000 -0.0866000 4.748105e-01 2.980802e-16 FALSE TRUE
ENST00000413017 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding protein_coding 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 1.156416 1.8407983 0.6935176 0.4331939 0.08214833 -1.395489 0.09318333 0.21140000 0.01873333 -0.1926667 2.980802e-16 2.980802e-16 FALSE TRUE
ENST00000431177 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding protein_coding 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 4.795492 1.1943158 8.5838608 0.6170981 0.64054410 2.835093 0.19110833 0.11876667 0.23086667 0.1121000 5.857420e-01 2.980802e-16 FALSE FALSE
ENST00000437996 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding nonsense_mediated_decay 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 4.889748 1.0618814 9.1662872 0.7625954 0.99799719 3.097765 0.18882083 0.09510000 0.24583333 0.1507333 4.756571e-01 2.980802e-16   FALSE
ENST00000440526 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding protein_coding 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 1.415961 0.2408289 3.3572183 0.1340132 0.39836795 3.746782 0.05150833 0.03436667 0.09066667 0.0563000 4.119059e-01 2.980802e-16 FALSE TRUE
ENST00000468349 ENSG00000205758 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYZL1 protein_coding retained_intron 21.9752 8.717566 37.19568 1.960774 0.6433547 2.091872 2.408999 0.6865692 3.8574280 0.1268330 0.40491017 2.473036 0.11762500 0.08616667 0.10346667 0.0173000 7.221764e-01 2.980802e-16   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205758 E001 13.003056 0.0172339779 7.731010e-02 1.551731e-01 21 33588782 33589033 252 - 1.166 0.940 -0.822
ENSG00000205758 E002 5.257123 0.0030489807 2.201900e-01 3.506615e-01 21 33589341 33589385 45 - 0.818 0.634 -0.754
ENSG00000205758 E003 15.588712 0.0019801732 9.837795e-01 9.939353e-01 21 33589386 33589460 75 - 1.182 1.185 0.011
ENSG00000205758 E004 13.514300 0.0026900407 6.797746e-01 7.838703e-01 21 33589461 33589466 6 - 1.111 1.153 0.151
ENSG00000205758 E005 13.372248 0.0062680531 4.928735e-01 6.299909e-01 21 33589467 33589467 1 - 1.098 1.170 0.256
ENSG00000205758 E006 25.730452 0.0007740171 2.787319e-01 4.183993e-01 21 33589468 33589544 77 - 1.367 1.447 0.277
ENSG00000205758 E007 16.729618 0.0010835862 9.556457e-01 9.761666e-01 21 33589545 33589559 15 - 1.219 1.216 -0.013
ENSG00000205758 E008 20.767819 0.0008950494 6.595886e-01 7.683709e-01 21 33589560 33589616 57 - 1.293 1.330 0.130
ENSG00000205758 E009 52.994538 0.0004419924 1.370440e-01 2.439747e-01 21 33589617 33589768 152 - 1.671 1.749 0.263
ENSG00000205758 E010 46.809072 0.0005560215 6.779711e-01 7.825458e-01 21 33589769 33589805 37 - 1.649 1.627 -0.077
ENSG00000205758 E011 44.766799 0.0012849163 9.512377e-01 9.735103e-01 21 33589806 33589840 35 - 1.624 1.621 -0.012
ENSG00000205758 E012 74.943373 0.0003841035 6.813493e-01 7.850601e-01 21 33589841 33589921 81 - 1.851 1.834 -0.057
ENSG00000205758 E013 65.342197 0.0084463827 2.204393e-01 3.509375e-01 21 33591162 33591207 46 - 1.808 1.735 -0.246
ENSG00000205758 E014 9.839485 0.0017723122 1.817667e-01 3.034444e-01 21 33591208 33591211 4 - 1.041 0.882 -0.595
ENSG00000205758 E015 8.693847 0.0024122086 2.795749e-01 4.193392e-01 21 33591212 33591228 17 - 0.984 0.849 -0.512
ENSG00000205758 E016 16.886172 0.0013164343 5.800752e-02 1.232156e-01 21 33591229 33591371 143 - 1.262 1.080 -0.650
ENSG00000205758 E017 21.548405 0.0375441421 4.197643e-01 5.630312e-01 21 33591372 33591718 347 - 1.342 1.233 -0.384
ENSG00000205758 E018 3.758203 0.0516244552 9.845329e-01 9.943903e-01 21 33594507 33594642 136 - 0.649 0.635 -0.060
ENSG00000205758 E019 2.355305 0.1098619306 5.453650e-01 6.757255e-01 21 33594643 33594661 19 - 0.543 0.419 -0.617
ENSG00000205758 E020 23.234684 0.0272398653 1.248068e-01 2.268537e-01 21 33594662 33595130 469 - 1.395 1.236 -0.557
ENSG00000205758 E021 13.933292 0.0074685369 2.066165e-03 7.429465e-03 21 33595131 33595336 206 - 1.219 0.849 -1.360
ENSG00000205758 E022 8.568118 0.0021086382 1.482265e-02 4.009347e-02 21 33595337 33595355 19 - 1.018 0.687 -1.286
ENSG00000205758 E023 23.148722 0.0427523078 3.735518e-01 5.179784e-01 21 33595356 33595528 173 - 1.377 1.249 -0.448
ENSG00000205758 E024 10.579396 0.0241815626 3.186756e-01 4.616454e-01 21 33595529 33595614 86 - 0.984 1.102 0.431
ENSG00000205758 E025 87.059043 0.0082338573 3.794439e-01 5.237182e-01 21 33595731 33595836 106 - 1.921 1.876 -0.151
ENSG00000205758 E026 4.682408 0.0037911497 9.866914e-01 9.957576e-01 21 33596003 33596061 59 - 0.734 0.733 -0.004
ENSG00000205758 E027 9.476561 0.0019673056 2.391645e-01 3.731315e-01 21 33596062 33596213 152 - 0.948 1.080 0.484
ENSG00000205758 E028 91.372903 0.0006383780 1.340649e-01 2.397979e-01 21 33597280 33597401 122 - 1.946 1.884 -0.208
ENSG00000205758 E029 69.920811 0.0073675079 9.219820e-01 9.547702e-01 21 33599150 33599195 46 - 1.812 1.813 0.001
ENSG00000205758 E030 73.013520 0.0064848328 2.045756e-01 3.318825e-01 21 33599196 33599248 53 - 1.854 1.773 -0.272
ENSG00000205758 E031 6.105356 0.0027816472 2.115299e-01 3.402994e-01 21 33599249 33599285 37 - 0.866 0.686 -0.717
ENSG00000205758 E032 65.368120 0.0073575512 3.064203e-01 4.485879e-01 21 33602234 33602266 33 - 1.802 1.732 -0.235
ENSG00000205758 E033 73.617160 0.0014958270 1.581535e-01 2.726593e-01 21 33602267 33602331 65 - 1.854 1.786 -0.231
ENSG00000205758 E034 37.064595 0.0005430409 6.293432e-02 1.316002e-01 21 33602332 33602332 1 - 1.576 1.456 -0.413
ENSG00000205758 E035 42.640074 0.0004868269 6.982491e-02 1.430871e-01 21 33602333 33602345 13 - 1.634 1.525 -0.372
ENSG00000205758 E036 0.810555 0.0149615690 7.771718e-01 8.565890e-01 21 33603156 33603403 248 - 0.248 0.191 -0.478
ENSG00000205758 E037 92.248844 0.0002987755 3.284637e-05 1.935384e-04 21 33603404 33603537 134 - 1.977 1.801 -0.593
ENSG00000205758 E038 79.934322 0.0003864107 3.591731e-07 3.269787e-06 21 33613538 33613606 69 - 1.929 1.690 -0.808
ENSG00000205758 E039 25.431785 0.0210370386 2.368903e-18 1.245232e-16 21 33616287 33616603 317 - 0.929 1.803 3.061
ENSG00000205758 E040 82.226514 0.0003322961 1.026558e-01 1.945543e-01 21 33616706 33616750 45 - 1.865 1.934 0.232
ENSG00000205758 E041 1.147939 0.0117917411 8.489644e-02 1.672425e-01 21 33616751 33617176 426 - 0.198 0.506 1.935
ENSG00000205758 E042 99.723296 0.0003421582 1.216960e-02 3.393626e-02 21 33621996 33622068 73 - 1.936 2.031 0.318
ENSG00000205758 E043 87.485446 0.0003864339 1.395820e-03 5.292913e-03 21 33624683 33624760 78 - 1.868 1.996 0.430
ENSG00000205758 E044 41.608532 0.0006229646 5.930576e-03 1.842577e-02 21 33631486 33631492 7 - 1.542 1.699 0.536
ENSG00000205758 E045 56.412590 0.0004786589 2.714429e-04 1.263490e-03 21 33631493 33631527 35 - 1.662 1.841 0.604
ENSG00000205758 E046 46.773130 0.0004716495 3.987634e-03 1.310809e-02 21 33631528 33631557 30 - 1.594 1.749 0.527
ENSG00000205758 E047 1.185505 0.0121930714 4.842054e-01 6.222275e-01 21 33633646 33633702 57 - 0.292 0.423 0.780
ENSG00000205758 E048 0.701914 0.0179511205 3.050819e-01 4.471226e-01 21 33639745 33640188 444 - 0.141 0.323 1.523
ENSG00000205758 E049 1.004945 0.1155352869 6.727660e-01 7.786273e-01 21 33641179 33641305 127 - 0.248 0.325 0.531
ENSG00000205758 E050 37.932188 0.0005992396 4.829312e-03 1.545594e-02 21 33641681 33642338 658 - 1.496 1.665 0.574
ENSG00000205758 E051 0.147249 0.0428182686 1.000000e+00   21 33643372 33643926 555 - 0.076 0.000 -7.679