ENSG00000205707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381356 ENSG00000205707 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFRF1 protein_coding protein_coding 9.553723 6.818008 14.6614 0.4255153 0.8159707 1.10347 6.1160845 2.9141059 10.499425 0.1310666 0.85055570 1.845616 0.57836250 0.4332333 0.7146333 0.28140000 2.437377e-04 5.719387e-17   FALSE
ENST00000555151 ENSG00000205707 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFRF1 protein_coding processed_transcript 9.553723 6.818008 14.6614 0.4255153 0.8159707 1.10347 1.8878705 3.3014398 1.500698 0.3702510 0.09339215 -1.132244 0.27825000 0.4815333 0.1034333 -0.37810000 5.719387e-17 5.719387e-17   FALSE
ENST00000557540 ENSG00000205707 HEK293_OSMI2_2hA HEK293_TMG_2hB ETFRF1 protein_coding protein_coding 9.553723 6.818008 14.6614 0.4255153 0.8159707 1.10347 0.7480753 0.3264942 1.591124 0.1582073 0.21464737 2.250431 0.06176667 0.0456000 0.1080333 0.06243333 1.536242e-01 5.719387e-17   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205707 E001 0.5901540 0.0193185039 9.369780e-01 9.643645e-01 12 25195216 25195236 21 + 0.205 0.184 -0.189
ENSG00000205707 E002 3.0248510 0.0050764484 3.950640e-01 5.389090e-01 12 25195237 25195260 24 + 0.532 0.672 0.620
ENSG00000205707 E003 4.0933974 0.0038900940 4.488884e-01 5.901005e-01 12 25195261 25195269 9 + 0.644 0.760 0.480
ENSG00000205707 E004 5.0522457 0.0032955431 4.169723e-01 5.603643e-01 12 25195270 25195271 2 + 0.717 0.833 0.465
ENSG00000205707 E005 6.0100497 0.0028386262 6.057201e-01 7.260570e-01 12 25195272 25195276 5 + 0.793 0.866 0.282
ENSG00000205707 E006 43.1053079 0.0005506038 9.953517e-01 1.000000e+00 12 25195277 25195337 61 + 1.614 1.620 0.020
ENSG00000205707 E007 5.9744761 0.0027693461 9.549862e-01 9.757624e-01 12 25195338 25195341 4 + 0.820 0.833 0.049
ENSG00000205707 E008 0.6633060 0.0204872640 9.393019e-01 9.658642e-01 12 25195553 25195640 88 + 0.205 0.184 -0.185
ENSG00000205707 E009 26.2059439 0.0013889620 9.299935e-28 1.289784e-25 12 25195708 25196184 477 + 1.018 1.764 2.598
ENSG00000205707 E010 4.9811449 0.0035192991 9.687003e-01 9.843946e-01 12 25203725 25203823 99 + 0.749 0.760 0.044
ENSG00000205707 E011 2.6894556 0.0072392756 9.921222e-01 9.991737e-01 12 25203824 25203832 9 + 0.557 0.561 0.017
ENSG00000205707 E012 55.5161209 0.0004816462 2.712431e-04 1.262684e-03 12 25203920 25204007 88 + 1.770 1.591 -0.608
ENSG00000205707 E013 0.4545463 0.5685125278 6.452920e-01 7.574124e-01 12 25204008 25204065 58 + 0.206 0.000 -9.238
ENSG00000205707 E014 0.7834997 0.1070009692 7.383454e-01 8.282401e-01 12 25204066 25204090 25 + 0.256 0.184 -0.603
ENSG00000205707 E015 204.1132820 0.0003576103 2.498416e-04 1.174630e-03 12 25204091 25205143 1053 + 2.300 2.237 -0.212
ENSG00000205707 E016 1.6357727 0.0632240728 1.478222e-01 2.587185e-01 12 25209195 25209645 451 + 0.478 0.184 -1.931