ENSG00000205643

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314567 ENSG00000205643 HEK293_OSMI2_2hA HEK293_TMG_2hB CDPF1 protein_coding protein_coding 16.00204 26.27008 6.97493 1.159296 0.4283684 -1.911652 8.4870819 13.215625 4.1986422 1.2120748 0.29276792 -1.651909 0.52966250 0.50176667 0.60553333 0.10376667 0.38749429 0.0111032 FALSE TRUE
ENST00000474256 ENSG00000205643 HEK293_OSMI2_2hA HEK293_TMG_2hB CDPF1 protein_coding processed_transcript 16.00204 26.27008 6.97493 1.159296 0.4283684 -1.911652 0.8260384 1.991313 0.4936140 0.1636643 0.49361396 -1.990557 0.05475833 0.07643333 0.06343333 -0.01300000 0.36366578 0.0111032 FALSE FALSE
ENST00000475605 ENSG00000205643 HEK293_OSMI2_2hA HEK293_TMG_2hB CDPF1 protein_coding processed_transcript 16.00204 26.27008 6.97493 1.159296 0.4283684 -1.911652 3.3459913 4.642326 0.8288500 0.2258773 0.04788894 -2.471467 0.21559167 0.17666667 0.11963333 -0.05703333 0.04534097 0.0111032 FALSE TRUE
MSTRG.22337.7 ENSG00000205643 HEK293_OSMI2_2hA HEK293_TMG_2hB CDPF1 protein_coding   16.00204 26.27008 6.97493 1.159296 0.4283684 -1.911652 1.0442337 1.577672 0.5864568 0.8856971 0.37869786 -1.412423 0.06140833 0.06196667 0.09096667 0.02900000 0.98419677 0.0111032 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205643 E001 0.5996172 0.3848312013 0.2669923277 0.4052650791 22 46244011 46244012 2 - 0.362 0.119 -2.048
ENSG00000205643 E002 2.0817930 0.4743784593 0.8482191679 0.9057503240 22 46244013 46244020 8 - 0.471 0.393 -0.410
ENSG00000205643 E003 16.5394987 0.0011344909 0.2757903998 0.4151681317 22 46244021 46244050 30 - 1.219 1.111 -0.384
ENSG00000205643 E004 48.9904112 0.0005438004 0.2342881165 0.3675091353 22 46244051 46244138 88 - 1.515 1.592 0.261
ENSG00000205643 E005 56.5634834 0.0004309147 0.6002283396 0.7215076772 22 46244139 46244172 34 - 1.615 1.645 0.102
ENSG00000205643 E006 80.7333282 0.0005140355 0.2423758662 0.3769782941 22 46244173 46244216 44 - 1.744 1.802 0.197
ENSG00000205643 E007 130.7363117 0.0007943417 0.4871322979 0.6248315973 22 46244217 46244323 107 - 1.975 2.002 0.093
ENSG00000205643 E008 129.1070361 0.0002512077 0.4889697996 0.6264680464 22 46244324 46244458 135 - 1.969 1.994 0.087
ENSG00000205643 E009 84.9460603 0.0003857262 0.0628815798 0.1315117257 22 46244459 46244525 67 - 1.734 1.825 0.310
ENSG00000205643 E010 67.2534460 0.0017278366 0.4541216169 0.5947925082 22 46244526 46244622 97 - 1.672 1.714 0.143
ENSG00000205643 E011 150.3368405 0.0004251203 0.8461461826 0.9043409298 22 46244623 46244908 286 - 2.049 2.055 0.020
ENSG00000205643 E012 129.1397212 0.0003539483 0.1477323650 0.2586067171 22 46244909 46245095 187 - 1.941 1.997 0.189
ENSG00000205643 E013 115.3522734 0.0003153239 0.8945304066 0.9366146408 22 46245096 46245230 135 - 1.941 1.945 0.015
ENSG00000205643 E014 45.7924083 0.0027853251 0.1291329240 0.2329668132 22 46245231 46245238 8 - 1.635 1.535 -0.340
ENSG00000205643 E015 8.6896481 0.0019693154 0.5131180420 0.6479671092 22 46246673 46246795 123 - 0.943 0.858 -0.325
ENSG00000205643 E016 5.2533183 0.0055690067 0.3732218128 0.5176609251 22 46247106 46247109 4 - 0.555 0.707 0.659
ENSG00000205643 E017 42.4387351 0.0005235205 0.6035483989 0.7243291937 22 46247110 46247124 15 - 1.489 1.523 0.118
ENSG00000205643 E018 63.4087927 0.0004300959 0.5521475492 0.6814669205 22 46247125 46247221 97 - 1.712 1.679 -0.113
ENSG00000205643 E019 21.1636858 0.0009203067 0.0032071679 0.0108764001 22 46248172 46248173 2 - 1.420 1.173 -0.864
ENSG00000205643 E020 40.5619447 0.0005543520 0.0001933564 0.0009353467 22 46248174 46248284 111 - 1.678 1.447 -0.791
ENSG00000205643 E021 3.1249802 0.0054125636 0.1977992314 0.3234791439 22 46248285 46248285 1 - 0.689 0.472 -0.987
ENSG00000205643 E022 16.2861778 0.0169633088 0.0851232446 0.1676056303 22 46249389 46249892 504 - 1.267 1.076 -0.684
ENSG00000205643 E023 5.6660489 0.0029677064 0.3328811368 0.4765503142 22 46249893 46249956 64 - 0.835 0.692 -0.573
ENSG00000205643 E024 35.3967571 0.0006484798 0.2048122842 0.3321583085 22 46250256 46250311 56 - 1.515 1.426 -0.308