ENSG00000205581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380749 ENSG00000205581 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGN1 protein_coding protein_coding 414.0786 425.2967 468.4597 28.20314 17.25853 0.1394524 372.4835 405.3515 396.23 28.07539 15.29943 -0.03283475 0.9026125 0.9528 0.8457 -0.1071 6.62661e-17 2.678755e-33 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205581 E001 128.0811747 3.838355e-03 6.484146e-12 1.391642e-10 21 39342315 39342337 23 - 1.929 2.219 0.973
ENSG00000205581 E002 3498.9662767 1.602804e-03 2.323241e-17 1.080076e-15 21 39342338 39342645 308 - 3.456 3.602 0.484
ENSG00000205581 E003 1501.6199300 1.794567e-03 4.119665e-13 1.073828e-11 21 39342646 39342691 46 - 3.088 3.236 0.492
ENSG00000205581 E004 2240.5578817 4.400140e-04 2.880064e-55 2.435802e-52 21 39342692 39342787 96 - 3.243 3.421 0.592
ENSG00000205581 E005 1207.3634538 5.179365e-04 8.207393e-25 8.839488e-23 21 39342788 39342799 12 - 3.001 3.139 0.460
ENSG00000205581 E006 1172.9114890 3.401020e-04 5.669305e-33 1.182856e-30 21 39342800 39342803 4 - 2.982 3.130 0.491
ENSG00000205581 E007 2341.4897154 4.527947e-04 3.211127e-13 8.491602e-12 21 39342804 39342878 75 - 3.327 3.400 0.243
ENSG00000205581 E008 1702.5775385 3.744910e-04 6.428242e-05 3.523759e-04 21 39342879 39342908 30 - 3.211 3.246 0.115
ENSG00000205581 E009 1625.7579912 1.299373e-04 1.888872e-16 7.850838e-15 21 39342909 39342977 69 - 3.172 3.241 0.230
ENSG00000205581 E010 1019.4006498 6.075385e-04 3.258586e-13 8.611094e-12 21 39342978 39343008 31 - 2.948 3.051 0.343
ENSG00000205581 E011 2451.2025125 1.304208e-04 3.259220e-14 9.941224e-13 21 39343009 39343136 128 - 3.360 3.411 0.169
ENSG00000205581 E012 1790.9339600 6.381737e-05 2.199628e-16 9.074760e-15 21 39343137 39343159 23 - 3.220 3.280 0.197
ENSG00000205581 E013 3814.6214270 1.290112e-04 6.804201e-05 3.707214e-04 21 39345146 39345274 129 - 3.605 3.560 -0.150
ENSG00000205581 E014 217.2333696 2.295935e-03 4.489668e-92 1.063193e-88 21 39345275 39345829 555 - 2.604 1.826 -2.604
ENSG00000205581 E015 212.1421928 1.223896e-02 3.552702e-20 2.308915e-18 21 39345830 39345958 129 - 2.553 1.969 -1.950
ENSG00000205581 E016 491.0752069 1.301532e-02 4.611296e-36 1.206625e-33 21 39345959 39347113 1155 - 2.958 2.174 -2.614
ENSG00000205581 E017 57.0734824 5.356581e-03 7.987274e-35 1.937471e-32 21 39347114 39347146 33 - 2.040 1.199 -2.873
ENSG00000205581 E018 65.8181634 5.962084e-03 2.304416e-33 4.989635e-31 21 39347147 39347246 100 - 2.091 1.295 -2.706
ENSG00000205581 E019 46.3178131 7.595563e-02 6.391915e-06 4.442472e-05 21 39347247 39347292 46 - 1.915 1.254 -2.260
ENSG00000205581 E020 23.6790713 4.210293e-03 8.491232e-16 3.238000e-14 21 39347293 39347335 43 - 1.638 0.942 -2.454
ENSG00000205581 E021 18.7400150 9.997011e-04 2.371194e-11 4.649784e-10 21 39347336 39347378 43 - 1.517 0.941 -2.044
ENSG00000205581 E022 167.1817038 2.607264e-04 7.422783e-48 4.040874e-45 21 39347379 39347478 100 - 2.411 1.973 -1.464
ENSG00000205581 E023 92.4639238 2.852849e-04 2.715987e-44 1.205002e-41 21 39347479 39347483 5 - 2.193 1.626 -1.909
ENSG00000205581 E024 48.8253118 4.486858e-04 3.827988e-53 2.789234e-50 21 39347484 39347491 8 - 1.988 1.028 -3.318
ENSG00000205581 E025 169.5360599 2.657727e-04 1.750562e-166 2.551067e-162 21 39347492 39347915 424 - 2.522 1.565 -3.214
ENSG00000205581 E026 39.9552497 6.995309e-04 1.248757e-35 3.171223e-33 21 39347916 39347952 37 - 1.884 1.066 -2.831
ENSG00000205581 E027 36.1612941 5.598631e-04 1.709626e-35 4.318448e-33 21 39347953 39347994 42 - 1.849 0.987 -3.003
ENSG00000205581 E028 40.3731156 4.973380e-04 1.790607e-40 6.400476e-38 21 39347995 39348064 70 - 1.899 1.015 -3.066
ENSG00000205581 E029 75.2793562 3.499305e-04 7.149558e-61 7.524790e-58 21 39348065 39348291 227 - 2.149 1.360 -2.677
ENSG00000205581 E030 2206.3865112 1.129469e-03 2.122900e-12 4.937111e-11 21 39348292 39348339 48 - 3.414 3.273 -0.469
ENSG00000205581 E031 57.2655444 4.064530e-04 3.813684e-28 5.456881e-26 21 39348340 39348421 82 - 1.985 1.422 -1.911
ENSG00000205581 E032 1887.1733225 1.969131e-03 4.794581e-11 8.932236e-10 21 39348422 39348451 30 - 3.359 3.190 -0.559
ENSG00000205581 E033 127.6166907 2.291173e-03 4.715876e-23 4.202298e-21 21 39348452 39348544 93 - 2.288 1.876 -1.380
ENSG00000205581 E034 1525.6473319 4.537056e-03 2.192823e-06 1.690432e-05 21 39348545 39348577 33 - 3.272 3.091 -0.600
ENSG00000205581 E035 98.4756598 1.739732e-03 2.344991e-17 1.089119e-15 21 39348578 39348862 285 - 2.160 1.792 -1.239
ENSG00000205581 E036 1742.2289456 9.540983e-03 2.902895e-04 1.340381e-03 21 39348903 39349140 238 - 3.335 3.142 -0.643
ENSG00000205581 E037 0.6923622 6.475443e-01 5.848118e-01 7.086348e-01 21 39349291 39349344 54 - 0.123 0.296 1.574
ENSG00000205581 E038 1.0371971 3.612212e-02 9.870155e-01 9.959315e-01 21 39349460 39349647 188 - 0.298 0.294 -0.026