ENSG00000205531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380542 ENSG00000205531 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L4 protein_coding protein_coding 92.50107 70.22243 123.4622 6.621105 1.799854 0.8139768 13.93549 11.427831 20.23469 1.3552857 0.7920539 0.8237301 0.1446625 0.1622333 0.1638333 0.0016000 9.947403e-01 1.590525e-16 FALSE TRUE
ENST00000620138 ENSG00000205531 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L4 protein_coding protein_coding 92.50107 70.22243 123.4622 6.621105 1.799854 0.8139768 50.64846 48.313510 58.89264 6.0659706 1.3926078 0.2856071 0.5687292 0.6844667 0.4769000 -0.2075667 5.132043e-07 1.590525e-16 FALSE TRUE
MSTRG.4977.8 ENSG00000205531 HEK293_OSMI2_2hA HEK293_TMG_2hB NAP1L4 protein_coding   92.50107 70.22243 123.4622 6.621105 1.799854 0.8139768 11.03192 2.185002 18.83773 0.4858096 2.5696288 3.1020966 0.1011292 0.0324000 0.1520667 0.1196667 5.222152e-05 1.590525e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205531 E001 2.8430699 0.0330074597 2.229872e-01 3.539409e-01 11 2944431 2944436 6 - 0.480 0.713 1.040
ENSG00000205531 E002 5.2669793 0.0371707377 1.054959e-02 3.009076e-02 11 2944437 2944437 1 - 0.578 1.003 1.706
ENSG00000205531 E003 1325.7168192 0.0038641281 3.122819e-22 2.550037e-20 11 2944438 2945062 625 - 2.948 3.279 1.100
ENSG00000205531 E004 321.5562889 0.0026639927 4.800740e-14 1.428661e-12 11 2945063 2945111 49 - 2.367 2.646 0.931
ENSG00000205531 E005 740.4029994 0.0022671086 4.559778e-13 1.182527e-11 11 2945112 2945330 219 - 2.757 2.983 0.750
ENSG00000205531 E006 533.1371633 0.0020830413 6.015651e-08 6.376361e-07 11 2945331 2945434 104 - 2.639 2.821 0.605
ENSG00000205531 E007 549.7270401 0.0001231917 1.685588e-18 9.028259e-17 11 2945435 2945596 162 - 2.658 2.831 0.577
ENSG00000205531 E008 394.7893757 0.0020055136 7.986776e-05 4.272280e-04 11 2945597 2945646 50 - 2.528 2.669 0.470
ENSG00000205531 E009 87.7152273 0.0004268374 8.032753e-02 1.600712e-01 11 2949227 2949264 38 - 1.898 2.001 0.345
ENSG00000205531 E010 9.9813652 0.0224739280 9.524064e-01 9.741891e-01 11 2950969 2951016 48 - 1.026 1.044 0.066
ENSG00000205531 E011 554.5839260 0.0009997955 9.376834e-04 3.746205e-03 11 2951259 2951315 57 - 2.695 2.797 0.338
ENSG00000205531 E012 486.6824013 0.0016745199 7.444385e-01 8.327845e-01 11 2951780 2951809 30 - 2.668 2.707 0.129
ENSG00000205531 E013 14.7723673 0.0154993542 4.789729e-01 6.173925e-01 11 2951810 2951897 88 - 1.143 1.250 0.379
ENSG00000205531 E014 58.8524402 0.0092669658 4.158700e-01 5.592132e-01 11 2951898 2952769 872 - 1.781 1.755 -0.090
ENSG00000205531 E015 14.1431642 0.0072954559 1.948036e-02 5.037394e-02 11 2954301 2954303 3 - 1.248 1.044 -0.731
ENSG00000205531 E016 26.7302119 0.0044874788 2.016524e-02 5.183014e-02 11 2954304 2954410 107 - 1.493 1.349 -0.495
ENSG00000205531 E017 14.2654574 0.0491284917 2.111027e-01 3.398328e-01 11 2954411 2954487 77 - 1.235 1.100 -0.480
ENSG00000205531 E018 15.2685899 0.0154754727 2.345639e-01 3.678319e-01 11 2954488 2954526 39 - 1.248 1.156 -0.325
ENSG00000205531 E019 556.9228917 0.0001697180 4.239704e-01 5.669829e-01 11 2954527 2954561 35 - 2.724 2.772 0.161
ENSG00000205531 E020 682.5658678 0.0001240411 8.290211e-01 8.926147e-01 11 2954562 2954646 85 - 2.817 2.855 0.129
ENSG00000205531 E021 481.1316156 0.0001418910 7.907052e-01 8.661524e-01 11 2955744 2955766 23 - 2.664 2.705 0.134
ENSG00000205531 E022 6.0560195 0.0027785315 3.130663e-01 4.555959e-01 11 2955767 2955790 24 - 0.879 0.780 -0.387
ENSG00000205531 E023 729.5024990 0.0001159381 7.687217e-01 8.505343e-01 11 2958399 2958483 85 - 2.849 2.880 0.105
ENSG00000205531 E024 449.6717155 0.0001213513 5.491878e-02 1.178610e-01 11 2958484 2958490 7 - 2.650 2.653 0.008
ENSG00000205531 E025 656.9650084 0.0000939460 3.739291e-08 4.132767e-07 11 2958491 2958544 54 - 2.834 2.790 -0.146
ENSG00000205531 E026 4.1271623 0.0828886600 3.247757e-01 4.681864e-01 11 2958545 2958934 390 - 0.765 0.596 -0.711
ENSG00000205531 E027 845.2179921 0.0003799195 5.433070e-07 4.772249e-06 11 2959770 2959909 140 - 2.942 2.899 -0.143
ENSG00000205531 E028 5.7527932 0.0030585113 3.729774e-03 1.238227e-02 11 2959910 2960131 222 - 0.606 1.009 1.603
ENSG00000205531 E029 435.3793081 0.0001167804 1.976905e-06 1.539505e-05 11 2964680 2964718 39 - 2.658 2.609 -0.161
ENSG00000205531 E030 315.8375642 0.0001393852 6.759385e-05 3.685234e-04 11 2964719 2964724 6 - 2.518 2.471 -0.156
ENSG00000205531 E031 356.2737921 0.0001381851 3.359068e-04 1.524119e-03 11 2964725 2964751 27 - 2.565 2.531 -0.114
ENSG00000205531 E032 429.3462694 0.0005222167 6.279806e-03 1.934645e-02 11 2969803 2969864 62 - 2.641 2.619 -0.072
ENSG00000205531 E033 443.5907299 0.0001541601 5.925013e-04 2.506198e-03 11 2969865 2969915 51 - 2.656 2.631 -0.085
ENSG00000205531 E034 347.3599857 0.0001320305 1.319062e-06 1.067369e-05 11 2969916 2969934 19 - 2.564 2.504 -0.200
ENSG00000205531 E035 325.0941975 0.0001542992 1.437091e-07 1.416360e-06 11 2971448 2971449 2 - 2.540 2.467 -0.243
ENSG00000205531 E036 360.8891491 0.0001383019 2.409546e-09 3.327850e-08 11 2971450 2971463 14 - 2.589 2.507 -0.271
ENSG00000205531 E037 517.7020567 0.0001162626 4.200883e-17 1.888573e-15 11 2971464 2971528 65 - 2.753 2.650 -0.343
ENSG00000205531 E038 325.2187116 0.0001473098 4.806411e-18 2.439872e-16 11 2971529 2971534 6 - 2.566 2.420 -0.485
ENSG00000205531 E039 440.7484064 0.0001131564 1.961104e-15 7.134003e-14 11 2972102 2972148 47 - 2.684 2.579 -0.351
ENSG00000205531 E040 318.2508859 0.0001867175 1.448706e-09 2.083134e-08 11 2972149 2972180 32 - 2.539 2.448 -0.304
ENSG00000205531 E041 256.9999235 0.0005635460 2.585272e-04 1.210689e-03 11 2972181 2972194 14 - 2.433 2.377 -0.185
ENSG00000205531 E042 402.5556880 0.0012141748 8.869034e-07 7.448739e-06 11 2972195 2972243 49 - 2.638 2.549 -0.297
ENSG00000205531 E043 16.7549871 0.0055497941 1.033938e-02 2.960334e-02 11 2972244 2972279 36 - 1.322 1.118 -0.720
ENSG00000205531 E044 514.3007573 0.0027682200 2.152951e-05 1.324770e-04 11 2976024 2976123 100 - 2.747 2.647 -0.333
ENSG00000205531 E045 371.5682649 0.0005732631 3.402473e-13 8.968809e-12 11 2978284 2978342 59 - 2.617 2.490 -0.425
ENSG00000205531 E046 273.1537810 0.0025370022 2.738084e-05 1.644205e-04 11 2979207 2979237 31 - 2.477 2.368 -0.362
ENSG00000205531 E047 0.3289534 0.0268860694 7.550762e-01   11 2981702 2981799 98 - 0.098 0.152 0.729
ENSG00000205531 E048 1.8863747 0.0075296299 6.561934e-01 7.658771e-01 11 2983746 2983813 68 - 0.480 0.427 -0.272
ENSG00000205531 E049 3.2378015 0.0446309681 3.986146e-01 5.423466e-01 11 2988077 2988126 50 - 0.548 0.715 0.727
ENSG00000205531 E050 46.8981642 0.0047069842 5.984266e-02 1.263458e-01 11 2989129 2989197 69 - 1.710 1.624 -0.293
ENSG00000205531 E051 7.6165875 0.0027760405 3.797802e-01 5.240297e-01 11 2989198 2989271 74 - 0.959 0.887 -0.272
ENSG00000205531 E052 0.7458221 0.0220620304 3.558633e-01 5.002298e-01 11 2990909 2990992 84 - 0.304 0.152 -1.274
ENSG00000205531 E053 16.0061688 0.0019104300 3.736350e-02 8.615485e-02 11 2991794 2992228 435 - 1.283 1.132 -0.535
ENSG00000205531 E054 7.3889979 0.0242884244 8.912861e-01 9.345540e-01 11 2992229 2992253 25 - 0.908 0.912 0.019
ENSG00000205531 E055 176.2447798 0.0004713302 4.125825e-09 5.455610e-08 11 2992254 2992377 124 - 2.299 2.161 -0.459