ENSG00000205476

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000557769 ENSG00000205476 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC85C protein_coding protein_coding 46.41383 68.17559 30.80776 5.011207 0.8856343 -1.145705 35.541626 56.168539 21.335894 3.523141 0.5643624 -1.39606051 0.7503125 0.82523333 0.6929 -0.1323333 4.410162e-06 1.250551e-11 FALSE TRUE
MSTRG.10164.3 ENSG00000205476 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC85C protein_coding   46.41383 68.17559 30.80776 5.011207 0.8856343 -1.145705 6.791009 6.796205 6.387318 1.546665 0.2338488 -0.08938345 0.1556208 0.09786667 0.2076 0.1097333 9.242275e-03 1.250551e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205476 E001 241.7946954 0.0008588451 7.031735e-21 5.008049e-19 14 99500190 99512031 11842 - 2.492 2.249 -0.811
ENSG00000205476 E002 1368.7444519 0.0026954744 1.005808e-11 2.094157e-10 14 99512032 99512804 773 - 2.943 3.122 0.595
ENSG00000205476 E003 817.9381144 0.0012754968 2.618155e-06 1.986549e-05 14 99512805 99513137 333 - 2.773 2.884 0.368
ENSG00000205476 E004 510.7093341 0.0001836151 1.312710e-03 5.019694e-03 14 99513138 99513324 187 - 2.600 2.668 0.223
ENSG00000205476 E005 1251.1662710 0.0003447696 2.444086e-06 1.865606e-05 14 99513325 99514080 756 - 2.986 3.058 0.240
ENSG00000205476 E006 1224.9245921 0.0001413541 9.033126e-01 9.424741e-01 14 99514081 99514960 880 - 3.022 3.032 0.034
ENSG00000205476 E007 322.0088590 0.0010113488 2.593155e-02 6.380568e-02 14 99514961 99515086 126 - 2.484 2.436 -0.159
ENSG00000205476 E008 302.5187227 0.0032882799 2.401545e-01 3.743186e-01 14 99515087 99515199 113 - 2.445 2.416 -0.097
ENSG00000205476 E009 302.7848736 0.0007537527 1.748375e-01 2.944820e-01 14 99515200 99515299 100 - 2.440 2.415 -0.084
ENSG00000205476 E010 212.6327778 0.0030930212 4.109464e-01 5.545370e-01 14 99515300 99515335 36 - 2.284 2.266 -0.060
ENSG00000205476 E011 304.1675369 0.0028361058 7.791244e-03 2.325332e-02 14 99516188 99516264 77 - 2.481 2.406 -0.252
ENSG00000205476 E012 226.8883483 0.0071365791 1.772792e-02 4.654630e-02 14 99516265 99516286 22 - 2.370 2.273 -0.326
ENSG00000205476 E013 287.2380558 0.0029842569 5.687722e-04 2.416944e-03 14 99517088 99517183 96 - 2.475 2.371 -0.347
ENSG00000205476 E014 240.7826725 0.0002014874 1.391837e-07 1.375981e-06 14 99522133 99522237 105 - 2.410 2.288 -0.409
ENSG00000205476 E015 85.8763885 0.0029183823 5.348562e-02 1.153566e-01 14 99522238 99522240 3 - 1.939 1.856 -0.281
ENSG00000205476 E016 3.9645809 0.0044987772 4.335092e-02 9.720323e-02 14 99522378 99522563 186 - 0.840 0.553 -1.203
ENSG00000205476 E017 7.5912220 0.0022577800 4.306349e-02 9.666401e-02 14 99522568 99522945 378 - 1.037 0.804 -0.881
ENSG00000205476 E018 158.4410411 0.0014244499 6.912798e-09 8.779304e-08 14 99536015 99536088 74 - 2.273 2.084 -0.632
ENSG00000205476 E019 0.5944058 0.2867070577 8.743980e-01 9.232643e-01 14 99572720 99572975 256 - 0.175 0.160 -0.155
ENSG00000205476 E020 0.3634088 0.3765556706 6.600291e-01   14 99576463 99576592 130 - 0.000 0.156 8.850
ENSG00000205476 E021 0.2214452 0.0377599279 1.000000e+00   14 99580021 99580126 106 - 0.000 0.085 9.247
ENSG00000205476 E022 275.2887060 0.0137730911 5.064537e-08 5.453621e-07 14 99603167 99604207 1041 - 2.586 2.282 -1.014