ENSG00000205423

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389134 ENSG00000205423 HEK293_OSMI2_2hA HEK293_TMG_2hB CNEP1R1 protein_coding nonsense_mediated_decay 8.566349 3.93609 13.22252 0.5838471 1.033583 1.745592 0.5516862 0.00000000 1.5373109 0.00000000 0.6753168 7.273619 0.04580417 0.0000 0.11083333 0.110833333 0.000062422 6.2422e-05   FALSE
ENST00000427478 ENSG00000205423 HEK293_OSMI2_2hA HEK293_TMG_2hB CNEP1R1 protein_coding protein_coding 8.566349 3.93609 13.22252 0.5838471 1.033583 1.745592 5.6575477 3.23899326 8.5605302 0.62166853 0.6631316 1.399392 0.69958750 0.8145 0.65860000 -0.155900000 0.325413741 6.2422e-05 FALSE FALSE
ENST00000566093 ENSG00000205423 HEK293_OSMI2_2hA HEK293_TMG_2hB CNEP1R1 protein_coding protein_coding 8.566349 3.93609 13.22252 0.5838471 1.033583 1.745592 1.0399091 0.06506594 1.0023958 0.06506594 0.4272619 3.753471 0.10513750 0.0130 0.07243333 0.059433333 0.178397483 6.2422e-05   FALSE
ENST00000567712 ENSG00000205423 HEK293_OSMI2_2hA HEK293_TMG_2hB CNEP1R1 protein_coding processed_transcript 8.566349 3.93609 13.22252 0.5838471 1.033583 1.745592 0.4849110 0.22348525 0.7741709 0.06402159 0.1592552 1.747837 0.05212917 0.0630 0.05736667 -0.005633333 1.000000000 6.2422e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205423 E001 0.2924217 0.0290785164 0.641875928   16 50024410 50025224 815 + 0.144 0.001 -8.094
ENSG00000205423 E002 1.0934249 0.4134287232 0.932755032 0.96162490 16 50025225 50025233 9 + 0.296 0.319 0.150
ENSG00000205423 E003 3.7528925 0.0499175816 0.523402155 0.65710818 16 50025234 50025240 7 + 0.675 0.569 -0.464
ENSG00000205423 E004 5.4490300 0.0097084002 0.501086759 0.63726392 16 50025241 50025254 14 + 0.800 0.725 -0.300
ENSG00000205423 E005 6.8527458 0.0078355012 0.653861451 0.76422582 16 50025255 50025261 7 + 0.874 0.840 -0.131
ENSG00000205423 E006 8.5877068 0.0059035543 0.472270601 0.61131106 16 50025262 50025263 2 + 0.967 0.903 -0.238
ENSG00000205423 E007 11.0212578 0.0076282781 0.918401611 0.95244550 16 50025264 50025270 7 + 1.035 1.071 0.133
ENSG00000205423 E008 13.0666366 0.0014678309 0.933784998 0.96226593 16 50025271 50025279 9 + 1.107 1.127 0.070
ENSG00000205423 E009 22.1016832 0.0011223573 0.170043412 0.28824627 16 50025280 50025340 61 + 1.355 1.273 -0.284
ENSG00000205423 E010 0.2924217 0.0290785164 0.641875928   16 50025341 50025345 5 + 0.144 0.000 -10.148
ENSG00000205423 E011 1.8498561 0.0079244131 0.811618885 0.88043772 16 50025435 50025519 85 + 0.443 0.417 -0.132
ENSG00000205423 E012 2.5141943 0.0065333635 0.394745933 0.53857989 16 50025520 50025650 131 + 0.551 0.418 -0.662
ENSG00000205423 E013 5.9631645 0.0210638640 0.089054773 0.17368417 16 50025651 50025701 51 + 0.875 0.626 -1.008
ENSG00000205423 E014 2.0087333 0.0144289706 0.289056795 0.42973071 16 50025702 50025784 83 + 0.500 0.317 -1.007
ENSG00000205423 E015 4.4560060 0.0546005491 0.086339102 0.16954324 16 50026160 50026395 236 + 0.787 0.495 -1.267
ENSG00000205423 E016 31.6971132 0.0067539106 0.038281097 0.08787610 16 50026396 50026467 72 + 1.522 1.390 -0.455
ENSG00000205423 E017 1.5908325 0.0087158639 0.895804726 0.93743014 16 50026699 50026859 161 + 0.376 0.418 0.231
ENSG00000205423 E018 35.3466675 0.0006378298 0.527437896 0.66050719 16 50029725 50029798 74 + 1.532 1.522 -0.033
ENSG00000205423 E019 50.0328042 0.0005392891 0.490834271 0.62816534 16 50033397 50033506 110 + 1.676 1.670 -0.021
ENSG00000205423 E020 26.0022092 0.0007827001 0.830752633 0.89383899 16 50034102 50034106 5 + 1.384 1.429 0.155
ENSG00000205423 E021 38.7541222 0.0006015042 0.224341869 0.35562031 16 50034107 50034156 50 + 1.580 1.536 -0.148
ENSG00000205423 E022 5.4594116 0.0279137452 0.560317946 0.68831941 16 50034157 50034668 512 + 0.800 0.726 -0.299
ENSG00000205423 E023 157.2415704 0.0002307326 0.005347770 0.01687800 16 50035417 50036175 759 + 2.181 2.135 -0.152
ENSG00000205423 E024 62.9859373 0.0083224361 0.003319394 0.01120404 16 50036176 50036467 292 + 1.704 1.903 0.670
ENSG00000205423 E025 101.7275231 0.0146472404 0.003068780 0.01046893 16 50036468 50037088 621 + 1.908 2.111 0.682