ENSG00000205356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000415086 ENSG00000205356 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR1 protein_coding protein_coding 7.752023 9.00353 5.054843 0.4994149 0.2396037 -0.8315747 0.1995942 0.000000 0.3638658 0.0000000 0.18352613 5.22444863 0.03165833 0.0000000 0.06890000 0.06890000 1.047150e-01 9.070457e-05 FALSE FALSE
ENST00000447648 ENSG00000205356 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR1 protein_coding protein_coding 7.752023 9.00353 5.054843 0.4994149 0.2396037 -0.8315747 3.8876602 6.245227 2.2357203 0.4722818 0.09850506 -1.47788405 0.48939167 0.6921333 0.44540000 -0.24673333 9.070457e-05 9.070457e-05 FALSE TRUE
ENST00000463648 ENSG00000205356 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR1 protein_coding retained_intron 7.752023 9.00353 5.054843 0.4994149 0.2396037 -0.8315747 0.6894592 0.000000 0.3401769 0.0000000 0.34017691 5.13001207 0.09392083 0.0000000 0.06323333 0.06323333 7.437675e-01 9.070457e-05 FALSE FALSE
MSTRG.30283.3 ENSG00000205356 HEK293_OSMI2_2hA HEK293_TMG_2hB TECPR1 protein_coding   7.752023 9.00353 5.054843 0.4994149 0.2396037 -0.8315747 1.6701166 1.488843 1.4419434 0.4319969 0.11196484 -0.04586416 0.22306250 0.1611667 0.28703333 0.12586667 2.430601e-01 9.070457e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205356 E001 16.6750112 0.0011993151 9.824533e-05 5.137824e-04 7 98214624 98215515 892 - 0.845 1.269 1.549
ENSG00000205356 E002 65.9108098 0.0098527149 5.233665e-05 2.934480e-04 7 98215516 98215729 214 - 1.532 1.829 1.010
ENSG00000205356 E003 36.8931397 0.0009445440 1.972609e-02 5.090789e-02 7 98215730 98215730 1 - 1.398 1.558 0.549
ENSG00000205356 E004 243.8797334 0.0016464939 2.633313e-06 1.996052e-05 7 98215731 98216736 1006 - 2.213 2.363 0.503
ENSG00000205356 E005 14.9601068 0.0013634556 7.239574e-01 8.176416e-01 7 98216737 98216759 23 - 1.114 1.150 0.129
ENSG00000205356 E006 27.0914746 0.0007131419 4.772667e-01 6.158465e-01 7 98216760 98216812 53 - 1.424 1.374 -0.171
ENSG00000205356 E007 135.4894888 0.0031711290 1.991200e-02 5.130450e-02 7 98216813 98217503 691 - 1.998 2.102 0.347
ENSG00000205356 E008 35.5650802 0.0029457218 7.995018e-01 8.720956e-01 7 98217692 98217742 51 - 1.519 1.504 -0.052
ENSG00000205356 E009 40.0669944 0.0005866429 5.143811e-01 6.490992e-01 7 98217743 98217811 69 - 1.580 1.543 -0.128
ENSG00000205356 E010 2.5505094 0.0604312637 1.369720e-01 2.438694e-01 7 98217812 98217838 27 - 0.699 0.428 -1.252
ENSG00000205356 E011 31.3460063 0.0015315807 9.943466e-01 1.000000e+00 7 98217936 98217966 31 - 1.447 1.449 0.005
ENSG00000205356 E012 40.1723103 0.0006701181 8.507499e-01 9.074285e-01 7 98217967 98218042 76 - 1.563 1.553 -0.033
ENSG00000205356 E013 52.7063431 0.0004704360 8.995179e-01 9.398822e-01 7 98221661 98221753 93 - 1.663 1.672 0.029
ENSG00000205356 E014 0.6245948 0.0261613933 3.197623e-01 4.628558e-01 7 98222385 98222385 1 - 0.000 0.214 12.019
ENSG00000205356 E015 61.4141235 0.0004852743 7.945316e-01 8.687338e-01 7 98222386 98222521 136 - 1.720 1.735 0.051
ENSG00000205356 E016 1.2490904 0.0117927350 9.494292e-01 9.723372e-01 7 98222522 98222876 355 - 0.301 0.314 0.083
ENSG00000205356 E017 0.5514428 0.0196227365 3.184898e-01 4.614610e-01 7 98222877 98222974 98 - 0.000 0.214 12.067
ENSG00000205356 E018 35.2151402 0.0006060837 4.510101e-01 5.920105e-01 7 98222990 98223030 41 - 1.455 1.507 0.178
ENSG00000205356 E019 58.2882511 0.0005090273 2.729006e-01 4.118668e-01 7 98223031 98223170 140 - 1.668 1.727 0.200
ENSG00000205356 E020 47.6189534 0.0004750250 2.580813e-01 3.952804e-01 7 98223662 98223718 57 - 1.574 1.641 0.228
ENSG00000205356 E021 0.6642364 0.0444511805 4.097788e-01 5.534108e-01 7 98223719 98223743 25 - 0.301 0.153 -1.240
ENSG00000205356 E022 52.7331724 0.0004378991 9.278164e-01 9.585776e-01 7 98224801 98224880 80 - 1.663 1.670 0.023
ENSG00000205356 E023 51.4992855 0.0029776252 7.536809e-01 8.395371e-01 7 98225006 98225102 97 - 1.649 1.669 0.071
ENSG00000205356 E024 2.8074792 0.0525801503 6.246867e-01 7.409441e-01 7 98226592 98226769 178 - 0.478 0.571 0.444
ENSG00000205356 E025 51.1516949 0.0004897098 8.654125e-01 9.172941e-01 7 98228014 98228116 103 - 1.663 1.656 -0.025
ENSG00000205356 E026 0.7728880 0.0161666080 1.946279e-01 3.195348e-01 7 98228508 98228684 177 - 0.000 0.267 12.492
ENSG00000205356 E027 0.1515154 0.0423159762 2.037603e-01   7 98228774 98229038 265 - 0.176 0.000 -12.625
ENSG00000205356 E028 21.0913100 0.0009071031 6.684248e-01 7.754319e-01 7 98229039 98229043 5 - 1.256 1.293 0.132
ENSG00000205356 E029 48.8871671 0.0023387226 8.899958e-01 9.337127e-01 7 98229044 98229166 123 - 1.639 1.634 -0.016
ENSG00000205356 E030 54.4998085 0.0176304472 8.765656e-01 9.247748e-01 7 98230961 98231118 158 - 1.668 1.691 0.077
ENSG00000205356 E031 48.4200838 0.0197301319 4.644270e-01 6.041425e-01 7 98231224 98231373 150 - 1.678 1.618 -0.202
ENSG00000205356 E032 0.5880631 0.1961853312 8.781468e-01 9.257515e-01 7 98231374 98231626 253 - 0.176 0.157 -0.202
ENSG00000205356 E033 52.6345797 0.0026931118 3.681671e-01 5.125676e-01 7 98231804 98231959 156 - 1.699 1.651 -0.162
ENSG00000205356 E034 52.8249709 0.0021294623 8.927704e-01 9.354761e-01 7 98232827 98232972 146 - 1.668 1.663 -0.014
ENSG00000205356 E035 4.2393842 0.0037620478 3.232754e-02 7.648846e-02 7 98232973 98233420 448 - 0.875 0.574 -1.241
ENSG00000205356 E036 20.6525925 0.0099201047 5.926810e-01 7.151879e-01 7 98233421 98233426 6 - 1.231 1.286 0.196
ENSG00000205356 E037 110.1109222 0.0003507816 3.515982e-01 4.958441e-01 7 98233427 98233911 485 - 2.005 1.972 -0.108
ENSG00000205356 E038 47.3973454 0.0005743040 6.222774e-02 1.303933e-01 7 98236776 98236862 87 - 1.695 1.595 -0.340
ENSG00000205356 E039 43.7616641 0.0005085472 2.584375e-01 3.956924e-01 7 98236863 98236921 59 - 1.634 1.571 -0.215
ENSG00000205356 E040 0.3299976 0.0279045799 5.549691e-01   7 98238504 98238508 5 - 0.000 0.153 11.435
ENSG00000205356 E041 56.9052490 0.0004666769 1.984993e-02 5.117062e-02 7 98238509 98238610 102 - 1.778 1.664 -0.387
ENSG00000205356 E042 52.6993695 0.0004175201 3.408060e-02 7.991271e-02 7 98240851 98240951 101 - 1.745 1.637 -0.365
ENSG00000205356 E043 67.3455627 0.0003715018 3.473169e-02 8.113615e-02 7 98241070 98241244 175 - 1.839 1.744 -0.322
ENSG00000205356 E044 51.3905309 0.0004679234 4.568991e-01 5.972753e-01 7 98243467 98243570 104 - 1.682 1.644 -0.129
ENSG00000205356 E045 28.4066568 0.0007309396 5.704535e-01 6.969336e-01 7 98243571 98243592 22 - 1.432 1.393 -0.133
ENSG00000205356 E046 44.8732683 0.0093934054 3.279811e-01 4.714414e-01 7 98244571 98244693 123 - 1.643 1.580 -0.217
ENSG00000205356 E047 38.8219782 0.0034638380 1.921830e-01 3.164957e-01 7 98244885 98244989 105 - 1.591 1.510 -0.279
ENSG00000205356 E048 30.5193670 0.0145556688 4.986655e-01 6.351140e-01 7 98244990 98245034 45 - 1.470 1.420 -0.173
ENSG00000205356 E049 20.9974735 0.0286224510 5.700823e-02 1.214743e-01 7 98245035 98245042 8 - 1.415 1.217 -0.691
ENSG00000205356 E050 26.1873080 0.0156886569 5.803685e-02 1.232723e-01 7 98245043 98245067 25 - 1.484 1.319 -0.570
ENSG00000205356 E051 1.1888288 0.0166194779 2.595487e-05 1.567944e-04 7 98245068 98245106 39 - 0.699 0.000 -15.806
ENSG00000205356 E052 61.1970332 0.0033387787 1.758774e-02 4.624168e-02 7 98245922 98246165 244 - 1.816 1.692 -0.420
ENSG00000205356 E053 0.0000000       7 98250914 98251393 480 -      
ENSG00000205356 E054 11.9662059 0.0016132952 8.276024e-01 8.916222e-01 7 98251394 98251418 25 - 1.061 1.040 -0.077
ENSG00000205356 E055 45.4864759 0.0063141612 1.977637e-01 3.234322e-01 7 98251419 98251548 130 - 1.658 1.579 -0.271
ENSG00000205356 E056 0.3686942 0.0280261221 5.286703e-01 6.615738e-01 7 98251790 98251900 111 - 0.176 0.084 -1.238
ENSG00000205356 E057 0.8576959 0.3114180178 3.219224e-01 4.651892e-01 7 98251901 98252125 225 - 0.400 0.156 -1.802
ENSG00000205356 E058 31.6604757 0.0114325829 1.472021e-01 2.578738e-01 7 98252126 98252232 107 - 1.525 1.415 -0.378