ENSG00000205189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379091 ENSG00000205189 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB10 protein_coding protein_coding 5.396634 1.344307 8.37448 0.1154743 0.4721046 2.630167 0.2811959 0.7857068 0.0247638 0.39294498 0.0247638 -4.5165792 0.1854833 0.5437000 0.002866667 -0.5408333 8.427975e-02 1.674614e-17 FALSE TRUE
ENST00000455036 ENSG00000205189 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB10 protein_coding protein_coding 5.396634 1.344307 8.37448 0.1154743 0.4721046 2.630167 2.0932349 0.2282230 4.1501277 0.08288875 0.2439049 4.1262433 0.3469583 0.1835000 0.497166667 0.3136667 2.769741e-02 1.674614e-17 FALSE TRUE
ENST00000610895 ENSG00000205189 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB10 protein_coding protein_coding 5.396634 1.344307 8.37448 0.1154743 0.4721046 2.630167 0.6258028 0.2882602 0.2407981 0.18205539 0.2407981 -0.2500454 0.1971375 0.2356667 0.027900000 -0.2077667 3.643992e-01 1.674614e-17 FALSE TRUE
MSTRG.31709.4 ENSG00000205189 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB10 protein_coding   5.396634 1.344307 8.37448 0.1154743 0.4721046 2.630167 2.2522709 0.0000000 3.7451559 0.00000000 0.3254908 8.5527290 0.2505625 0.0000000 0.446233333 0.4462333 1.674614e-17 1.674614e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205189 E001 0.1515154 0.0429305791 1.000000e+00   8 80485420 80485618 199 + 0.047 0.000 -8.400
ENSG00000205189 E002 0.6696487 0.0224310659 7.788660e-01 8.577415e-01 8 80485619 80485666 48 + 0.128 0.286 1.442
ENSG00000205189 E003 1.2724882 0.2261736342 6.592473e-01 7.681088e-01 8 80485667 80485688 22 + 0.227 0.457 1.436
ENSG00000205189 E004 2.0893860 0.1444524143 7.211523e-01 8.156183e-01 8 80485689 80485879 191 + 0.331 0.582 1.298
ENSG00000205189 E005 0.6664265 0.0162815911 1.747601e-01 2.943986e-01 8 80485880 80485883 4 + 0.089 0.456 3.025
ENSG00000205189 E006 0.6234514 0.5935846454 6.850555e-01 7.878546e-01 8 80486213 80486225 13 + 0.128 0.287 1.451
ENSG00000205189 E007 6.3683304 0.0146921285 3.211380e-02 7.607682e-02 8 80486226 80486248 23 + 0.736 0.579 -0.671
ENSG00000205189 E008 13.4459642 0.0176519483 2.453608e-03 8.625189e-03 8 80486249 80486306 58 + 1.019 0.819 -0.757
ENSG00000205189 E009 16.7510345 0.0013570025 2.763611e-04 1.283481e-03 8 80486307 80486399 93 + 1.105 0.926 -0.661
ENSG00000205189 E010 47.9755504 0.0645851920 2.672861e-04 1.246407e-03 8 80486400 80487293 894 + 1.547 1.294 -0.873
ENSG00000205189 E011 63.9641453 0.0004156453 1.934522e-16 8.017707e-15 8 80487294 80487782 489 + 1.671 1.384 -0.982
ENSG00000205189 E012 136.5410887 0.0136948553 2.659641e-09 3.646410e-08 8 80499494 80500382 889 + 1.980 1.854 -0.422
ENSG00000205189 E013 31.4602645 0.0008797769 2.184423e-01 3.485345e-01 8 80513910 80514008 99 + 1.312 1.500 0.652
ENSG00000205189 E014 20.0055317 0.0011030109 3.235766e-01 4.668910e-01 8 80518403 80518438 36 + 1.128 1.312 0.650
ENSG00000205189 E015 23.3996908 0.0007924263 3.154388e-02 7.496572e-02 8 80518439 80518510 72 + 1.212 1.292 0.281
ENSG00000205189 E016 30.6662571 0.0006842560 3.056211e-05 1.814788e-04 8 80518511 80518579 69 + 1.342 1.248 -0.328
ENSG00000205189 E017 53.2656484 0.0004682165 1.766592e-05 1.109042e-04 8 80518782 80518954 173 + 1.563 1.571 0.025
ENSG00000205189 E018 514.0233608 0.0422765606 1.895905e-07 1.824883e-06 8 80519223 80526265 7043 + 2.430 2.936 1.685