ENSG00000205133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378861 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding protein_coding 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.4024707 0.0000000 0.7496110 0.00000000 0.33580771 6.2471889 0.07263750 0.0000000 0.12206667 0.12206667 1.308107e-01 2.931907e-07   FALSE
ENST00000518748 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding protein_coding 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.8713999 0.0000000 1.9525928 0.00000000 0.23741671 7.6166171 0.18392917 0.0000000 0.31270000 0.31270000 2.931907e-07 2.931907e-07   FALSE
ENST00000519792 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding processed_transcript 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.1260490 0.1205772 0.3248911 0.09064259 0.09120279 1.3587888 0.08360000 0.1266667 0.05186667 -0.07480000 6.081255e-01 2.931907e-07   FALSE
ENST00000521988 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding protein_coding 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.9090728 0.5962429 0.7603449 0.17095508 0.43569260 0.3456087 0.37986667 0.7386667 0.12433333 -0.61433333 6.336318e-02 2.931907e-07   FALSE
ENST00000524037 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding protein_coding 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.3666572 0.0000000 0.8340166 0.00000000 0.44537811 6.3991995 0.05963333 0.0000000 0.13173333 0.13173333 5.188150e-01 2.931907e-07   FALSE
ENST00000537541 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding protein_coding 3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.1176937 0.0000000 0.4017980 0.00000000 0.25616544 5.3638650 0.03947917 0.0000000 0.06393333 0.06393333 3.010774e-01 2.931907e-07   FALSE
MSTRG.31802.14 ENSG00000205133 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIQK protein_coding   3.71383 0.8118019 6.223212 0.1975725 0.1080306 2.923113 0.3393089 0.0000000 1.0107556 0.00000000 0.12820936 6.6734937 0.05870000 0.0000000 0.16260000 0.16260000 2.695272e-04 2.931907e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000205133 E001 0.1451727 0.0477587963 8.903544e-01   8 92883532 92883533 2 - 0.053 0.000 -7.277
ENSG00000205133 E002 1.3629428 0.0096765512 2.723290e-02 6.646131e-02 8 92883534 92883634 101 - 0.216 0.631 2.343
ENSG00000205133 E003 82.8262228 0.0003577088 4.582746e-08 4.980424e-07 8 92883635 92885319 1685 - 1.748 1.983 0.789
ENSG00000205133 E004 3.5398558 0.0046779720 1.211732e-01 2.216121e-01 8 92885320 92885334 15 - 0.599 0.260 -1.857
ENSG00000205133 E005 3.6881490 0.0042526934 3.695120e-01 5.139226e-01 8 92885335 92885348 14 - 0.599 0.422 -0.857
ENSG00000205133 E006 3.3936510 0.0051058740 4.541534e-01 5.948177e-01 8 92885349 92885350 2 - 0.570 0.421 -0.726
ENSG00000205133 E007 15.2474647 0.0028430065 7.205536e-04 2.972487e-03 8 92885351 92885713 363 - 1.023 1.363 1.209
ENSG00000205133 E008 37.5473998 0.0177257674 2.004467e-02 5.158254e-02 8 92885714 92886232 519 - 1.420 1.618 0.678
ENSG00000205133 E009 8.7521246 0.0021277559 4.206447e-01 5.638329e-01 8 92886233 92886234 2 - 0.849 0.964 0.434
ENSG00000205133 E010 19.7645321 0.0010369110 3.019572e-01 4.437790e-01 8 92886235 92886389 155 - 1.175 1.280 0.371
ENSG00000205133 E011 13.8201417 0.0013444066 4.296675e-01 5.723642e-01 8 92886390 92886424 35 - 1.029 1.124 0.345
ENSG00000205133 E012 19.3811513 0.0011789593 8.842914e-01 9.300629e-01 8 92886425 92886533 109 - 1.178 1.198 0.069
ENSG00000205133 E013 13.5935143 0.0013559616 9.057286e-01 9.440350e-01 8 92886534 92886554 21 - 1.044 1.035 -0.034
ENSG00000205133 E014 18.7964763 0.0010520802 3.843113e-01 5.284803e-01 8 92886555 92886592 38 - 1.186 1.096 -0.321
ENSG00000205133 E015 18.5581704 0.0010460393 7.625023e-03 2.283674e-02 8 92886593 92886657 65 - 1.207 0.878 -1.204
ENSG00000205133 E016 11.7540304 0.0021648841 1.110733e-02 3.142453e-02 8 92886658 92886662 5 - 1.029 0.631 -1.562
ENSG00000205133 E017 10.0524806 0.0029688810 2.155916e-03 7.707717e-03 8 92886663 92886667 5 - 0.979 0.422 -2.378
ENSG00000205133 E018 12.8771958 0.0014224464 1.011296e-03 3.997641e-03 8 92886668 92886735 68 - 1.074 0.539 -2.141
ENSG00000205133 E019 0.0000000       8 92886736 92886757 22 -      
ENSG00000205133 E020 15.1190422 0.0014148554 9.530963e-03 2.761466e-02 8 92891989 92892066 78 - 1.127 0.772 -1.334
ENSG00000205133 E021 9.4984324 0.0029852419 1.654971e-02 4.394896e-02 8 92892067 92892074 8 - 0.948 0.539 -1.680
ENSG00000205133 E022 10.5541677 0.0021943270 7.307439e-03 2.201785e-02 8 92916929 92916966 38 - 0.990 0.539 -1.836
ENSG00000205133 E023 12.8624326 0.0013741030 5.070507e-03 1.612327e-02 8 92916967 92917007 41 - 1.064 0.632 -1.690
ENSG00000205133 E024 6.5754057 0.0025520658 3.772973e-01 5.216256e-01 8 92917008 92917010 3 - 0.781 0.632 -0.618
ENSG00000205133 E025 5.8232423 0.0113307543 8.703499e-02 1.706497e-01 8 92921503 92921660 158 - 0.762 0.422 -1.542
ENSG00000205133 E026 0.1515154 0.0486956609 8.913077e-01   8 92922254 92922602 349 - 0.053 0.000 -9.292
ENSG00000205133 E027 0.0000000       8 92953415 92954082 668 -      
ENSG00000205133 E028 0.0000000       8 92954083 92954405 323 -      
ENSG00000205133 E029 16.9961677 0.0011845615 2.382425e-02 5.945174e-02 8 92954406 92954564 159 - 1.163 0.879 -1.047
ENSG00000205133 E030 0.2903454 0.3851607065 1.000000e+00   8 92960501 92960719 219 - 0.099 0.000 -9.606
ENSG00000205133 E031 0.1472490 0.0514691444 8.916483e-01   8 92963477 92963865 389 - 0.053 0.000 -9.281
ENSG00000205133 E032 1.2596890 0.0107557301 3.991375e-01 5.428757e-01 8 92964886 92964956 71 - 0.249 0.422 1.082
ENSG00000205133 E033 0.3332198 0.0858299286 1.736502e-01   8 92964985 92965504 520 - 0.053 0.260 2.668
ENSG00000205133 E034 0.2903454 0.3851607065 1.000000e+00   8 92965505 92965807 303 - 0.099 0.000 -9.606
ENSG00000205133 E035 0.4847352 0.3461251768 3.293477e-01 4.728551e-01 8 92965808 92966006 199 - 0.100 0.261 1.666
ENSG00000205133 E036 10.7348373 0.0017121167 5.306563e-01 6.632224e-01 8 92966007 92966144 138 - 0.961 0.879 -0.311
ENSG00000205133 E037 0.0000000       8 93017609 93017673 65 -