ENSG00000204954

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378090 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 2.165905 1.864686 2.252787 0.3474203 0.3358491 0.27145181 0.08660417 0.08473333 0.07956667 -0.005166667 0.901903306 0.003406558    
ENST00000547945 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 2.411261 1.585799 3.205111 0.1471554 0.3321028 1.01058948 0.09918333 0.07516667 0.11283333 0.037666667 0.303785209 0.003406558 FALSE  
ENST00000547975 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 4.853803 5.038134 6.665605 0.7886274 0.7842351 0.40314846 0.19739167 0.23020000 0.23110000 0.000900000 1.000000000 0.003406558    
ENST00000549478 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 2.968105 3.212494 2.421327 0.6034659 0.2265684 -0.40643358 0.12546667 0.14583333 0.08416667 -0.061666667 0.003406558 0.003406558    
ENST00000552940 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 2.409297 2.437330 3.373310 0.6785023 0.1675032 0.46722666 0.10042917 0.11596667 0.11803333 0.002066667 0.925063183 0.003406558    
ENST00000553183 ENSG00000204954 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf73 protein_coding protein_coding 24.4114 21.80734 28.67744 3.084165 0.9858338 0.3949436 6.396485 6.458782 6.860910 0.9860934 1.1995706 0.08700711 0.26347917 0.29556667 0.23700000 -0.058566667 0.486036577 0.003406558    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204954 E001 3.9211323 0.0197996177 3.687349e-03 1.225948e-02 12 103940763 103942093 1331 - 0.877 0.419 -2.006
ENSG00000204954 E002 0.1515154 0.0434321427 4.979714e-01   12 103950194 103950201 8 - 0.123 0.000 -8.290
ENSG00000204954 E003 7.4197001 0.0637445755 9.994068e-01 1.000000e+00 12 103950202 103950739 538 - 0.912 0.950 0.142
ENSG00000204954 E004 2.5453100 0.0065837543 2.152704e-01 3.447366e-01 12 103950740 103950744 5 - 0.420 0.628 0.992
ENSG00000204954 E005 17.0999777 0.0098441286 5.405036e-01 6.716481e-01 12 103950745 103950873 129 - 1.222 1.288 0.234
ENSG00000204954 E006 46.8107770 0.0040966832 2.324853e-01 3.653982e-01 12 103950874 103951127 254 - 1.638 1.714 0.258
ENSG00000204954 E007 46.2538882 0.0032564100 3.001081e-01 4.417468e-01 12 103951128 103951261 134 - 1.644 1.710 0.224
ENSG00000204954 E008 56.3904542 0.0006814829 6.229835e-01 7.396728e-01 12 103951262 103951281 20 - 1.776 1.761 -0.052
ENSG00000204954 E009 142.7846779 0.0021351076 8.528959e-02 1.678714e-01 12 103951282 103951409 128 - 2.127 2.193 0.223
ENSG00000204954 E010 99.6731404 0.0047209415 3.918913e-02 8.953202e-02 12 103951410 103951419 10 - 1.950 2.051 0.337
ENSG00000204954 E011 118.8802313 0.0058760324 2.139320e-01 3.431722e-01 12 103951420 103951479 60 - 2.047 2.113 0.221
ENSG00000204954 E012 187.5687382 0.0003316062 4.280001e-01 5.708003e-01 12 103951480 103951583 104 - 2.265 2.292 0.090
ENSG00000204954 E013 175.3902332 0.0017110776 1.639597e-01 2.803063e-01 12 103951584 103951630 47 - 2.270 2.228 -0.140
ENSG00000204954 E014 86.8084871 0.0003314395 1.702522e-03 6.291210e-03 12 103953414 103953534 121 - 2.004 1.895 -0.366
ENSG00000204954 E015 9.3305247 0.0019242175 4.110271e-08 4.510679e-07 12 103954652 103954874 223 - 1.247 0.628 -2.359
ENSG00000204954 E016 9.7815435 0.0018586036 1.122544e-04 5.781858e-04 12 103954875 103954968 94 - 1.213 0.814 -1.476
ENSG00000204954 E017 3.1084853 0.0215472475 2.643569e-01 4.023172e-01 12 103955706 103955771 66 - 0.692 0.515 -0.783
ENSG00000204954 E018 5.8985453 0.0281328918 6.365809e-05 3.493579e-04 12 103956304 103956630 327 - 1.071 0.468 -2.475
ENSG00000204954 E019 246.8842127 0.0002595626 9.123658e-02 1.770610e-01 12 103956631 103956748 118 - 2.414 2.384 -0.099
ENSG00000204954 E020 86.6122927 0.0047680993 2.422764e-02 6.028052e-02 12 103956749 103957068 320 - 1.883 1.992 0.365
ENSG00000204954 E021 121.7010079 0.0036787113 4.603563e-01 6.004015e-01 12 103957069 103957139 71 - 2.107 2.077 -0.100
ENSG00000204954 E022 65.2539061 0.0017691999 8.926910e-01 9.354317e-01 12 103957140 103957273 134 - 1.826 1.826 0.000
ENSG00000204954 E023 19.9775146 0.0009693223 1.919197e-01 3.161783e-01 12 103965516 103965708 193 - 1.262 1.369 0.372