ENSG00000204852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480648 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding nonsense_mediated_decay 21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 1.2871659 1.3063243 0.9908286 0.6734984 0.1709574 -0.3953200 0.05992083 0.06976667 0.0334000 -0.03636667 9.668789e-01 6.141493e-12 FALSE TRUE
ENST00000546643 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding nonsense_mediated_decay 21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 0.8154857 0.1861532 2.0288602 0.1861532 0.6886875 3.3777102 0.04018333 0.01130000 0.0692000 0.05790000 1.154516e-01 6.141493e-12 FALSE FALSE
ENST00000550703 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding protein_coding 21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 0.9770433 0.0000000 1.5841969 0.0000000 0.3334278 7.3166861 0.04066250 0.00000000 0.0532000 0.05320000 6.141493e-12 6.141493e-12 FALSE TRUE
ENST00000551590 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding protein_coding 21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 0.9992714 2.3070245 1.4912368 0.1722927 1.0856757 -0.6261217 0.05292083 0.12880000 0.0529000 -0.07590000 4.774838e-01 6.141493e-12 FALSE TRUE
ENST00000614115 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding protein_coding 21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 2.4366997 2.7880166 3.1808663 0.3607438 1.1869309 0.1895436 0.11414167 0.15360000 0.1066000 -0.04700000 6.211585e-01 6.141493e-12 FALSE TRUE
MSTRG.8017.38 ENSG00000204852 HEK293_OSMI2_2hA HEK293_TMG_2hB TCTN1 protein_coding   21.37627 18.04834 29.45445 0.866296 0.9313943 0.7063106 5.3160895 4.0784655 7.5762559 0.2814545 0.8344774 0.8918286 0.24384167 0.22750000 0.2562333 0.02873333 7.670150e-01 6.141493e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204852 E001 0.3634088 0.3618886598 2.175043e-01   12 110614027 110614062 36 + 0.000 0.241 11.416
ENSG00000204852 E002 5.7517541 0.0030189837 7.733167e-01 8.537195e-01 12 110614063 110614101 39 + 0.848 0.814 -0.136
ENSG00000204852 E003 6.3816621 0.0026155248 6.070995e-01 7.271492e-01 12 110614102 110614105 4 + 0.899 0.837 -0.236
ENSG00000204852 E004 6.3816621 0.0026155248 6.070995e-01 7.271492e-01 12 110614106 110614106 1 + 0.899 0.837 -0.236
ENSG00000204852 E005 7.1492540 0.0023499373 5.850816e-01 7.088471e-01 12 110614107 110614111 5 + 0.944 0.881 -0.236
ENSG00000204852 E006 7.2944267 0.0023037662 5.029328e-01 6.389340e-01 12 110614112 110614112 1 + 0.958 0.881 -0.288
ENSG00000204852 E007 8.6617231 0.0019756947 4.483178e-01 5.896040e-01 12 110614113 110614123 11 + 1.022 0.940 -0.302
ENSG00000204852 E008 9.1120030 0.0018726081 2.755523e-01 4.148785e-01 12 110614124 110614125 2 + 1.056 0.940 -0.428
ENSG00000204852 E009 9.4806972 0.0017646086 2.986201e-01 4.400797e-01 12 110614126 110614127 2 + 1.067 0.958 -0.400
ENSG00000204852 E010 9.6322126 0.0018478322 2.525796e-01 3.889553e-01 12 110614128 110614128 1 + 1.078 0.958 -0.439
ENSG00000204852 E011 9.6322126 0.0018478322 2.525796e-01 3.889553e-01 12 110614129 110614129 1 + 1.078 0.958 -0.439
ENSG00000204852 E012 11.7597286 0.0014771991 7.576201e-02 1.527191e-01 12 110614130 110614136 7 + 1.180 1.008 -0.621
ENSG00000204852 E013 12.0219614 0.0014360060 2.820185e-02 6.841529e-02 12 110614137 110614138 2 + 1.204 0.992 -0.766
ENSG00000204852 E014 18.8059455 0.0015297284 5.961836e-03 1.850681e-02 12 110614139 110614147 9 + 1.387 1.164 -0.780
ENSG00000204852 E015 19.2615359 0.0010675463 5.104516e-03 1.621536e-02 12 110614148 110614152 5 + 1.397 1.175 -0.777
ENSG00000204852 E016 24.2007949 0.0007874580 1.208760e-01 2.212008e-01 12 110614153 110614163 11 + 1.449 1.341 -0.372
ENSG00000204852 E017 30.1397570 0.0006792837 1.763783e-02 4.635704e-02 12 110614164 110614164 1 + 1.558 1.408 -0.515
ENSG00000204852 E018 33.5947388 0.0006325069 2.766098e-02 6.733773e-02 12 110614165 110614167 3 + 1.598 1.467 -0.450
ENSG00000204852 E019 42.9795190 0.0005432888 5.170888e-02 1.121990e-01 12 110614168 110614180 13 + 1.691 1.589 -0.348
ENSG00000204852 E020 138.9270396 0.0008573385 1.636708e-03 6.078839e-03 12 110614181 110614402 222 + 2.193 2.092 -0.336
ENSG00000204852 E021 4.8617043 0.0121656817 9.211174e-01 9.542284e-01 12 110614403 110614463 61 + 0.771 0.787 0.065
ENSG00000204852 E022 0.7834997 0.1434112605 3.198169e-01 4.629050e-01 12 110616277 110616352 76 + 0.334 0.136 -1.652
ENSG00000204852 E023 0.4386386 0.1674181740 7.474579e-01 8.349568e-01 12 110616721 110616747 27 + 0.197 0.135 -0.661
ENSG00000204852 E024 3.2755573 0.0111316399 6.262176e-02 1.310595e-01 12 110616748 110616904 157 + 0.749 0.453 -1.327
ENSG00000204852 E025 112.1087708 0.0023495226 9.509673e-05 4.990109e-04 12 110619836 110619956 121 + 2.122 1.965 -0.528
ENSG00000204852 E026 0.3686942 0.0358097652 8.581888e-01 9.125105e-01 12 110623531 110623583 53 + 0.110 0.136 0.353
ENSG00000204852 E027 122.6179927 0.0035495616 2.745248e-05 1.647906e-04 12 110626362 110626434 73 + 2.170 1.990 -0.601
ENSG00000204852 E028 103.6679581 0.0037582214 2.220229e-03 7.906570e-03 12 110626435 110626492 58 + 2.081 1.942 -0.468
ENSG00000204852 E029 0.1515154 0.0436644196 6.135167e-01   12 110626881 110627929 1049 + 0.110 0.000 -10.153
ENSG00000204852 E030 1.5155921 0.0086902976 1.948298e-02 5.037735e-02 12 110627930 110628051 122 + 0.556 0.136 -2.820
ENSG00000204852 E031 4.3972210 0.1477602298 1.439440e-01 2.533822e-01 12 110628052 110628224 173 + 0.866 0.510 -1.506
ENSG00000204852 E032 72.5546845 0.0012281605 1.347076e-02 3.701334e-02 12 110628767 110628796 30 + 1.914 1.805 -0.366
ENSG00000204852 E033 143.4300687 0.0011568383 1.948959e-02 5.039045e-02 12 110628797 110628918 122 + 2.196 2.120 -0.254
ENSG00000204852 E034 105.5475078 0.0008348948 1.170116e-38 3.725629e-36 12 110628919 110630287 1369 + 2.208 1.694 -1.726
ENSG00000204852 E035 134.6538318 0.0011272987 9.541147e-01 9.752519e-01 12 110632472 110632559 88 + 2.131 2.134 0.009
ENSG00000204852 E036 8.2948643 0.0028505619 4.007105e-06 2.914477e-05 12 110632560 110633449 890 + 1.163 0.595 -2.206
ENSG00000204852 E037 0.9545818 0.0146291061 5.977228e-01 7.194571e-01 12 110634311 110634395 85 + 0.333 0.239 -0.650
ENSG00000204852 E038 5.9071692 0.0726222412 7.723652e-01 8.530568e-01 12 110634396 110634463 68 + 0.829 0.858 0.111
ENSG00000204852 E039 3.2970866 0.1588127188 4.125654e-01 5.561237e-01 12 110634464 110634669 206 + 0.725 0.508 -0.956
ENSG00000204852 E040 120.5220446 0.0003082965 9.247620e-01 9.566248e-01 12 110634670 110634779 110 + 2.085 2.090 0.017
ENSG00000204852 E041 4.6939200 0.0036013946 2.363561e-01 3.699434e-01 12 110635667 110635950 284 + 0.830 0.669 -0.651
ENSG00000204852 E042 5.7761841 0.0031728124 7.766781e-02 1.557129e-01 12 110635951 110636244 294 + 0.929 0.702 -0.892
ENSG00000204852 E043 3.2158943 0.0176516327 1.635600e-01 2.797651e-01 12 110636245 110636369 125 + 0.726 0.505 -0.976
ENSG00000204852 E044 3.3139512 0.0066143565 2.459977e-01 3.812586e-01 12 110636370 110636480 111 + 0.726 0.552 -0.752
ENSG00000204852 E045 82.3300448 0.0004363167 5.578387e-01 6.861681e-01 12 110636481 110636501 21 + 1.930 1.909 -0.072
ENSG00000204852 E046 151.6514236 0.0002976626 1.209633e-01 2.213198e-01 12 110640383 110640517 135 + 2.164 2.211 0.155
ENSG00000204852 E047 108.2620170 0.0068977230 9.304980e-02 1.798923e-01 12 110641024 110641149 126 + 1.996 2.084 0.295
ENSG00000204852 E048 96.7475383 0.0019151048 1.533101e-03 5.743580e-03 12 110641542 110641627 86 + 1.926 2.057 0.440
ENSG00000204852 E049 2.3572640 0.0588649521 6.542830e-01 7.645021e-01 12 110641628 110641629 2 + 0.480 0.555 0.359
ENSG00000204852 E050 16.9944517 0.0010611276 4.737547e-01 6.126585e-01 12 110641630 110642248 619 + 1.227 1.287 0.212
ENSG00000204852 E051 106.7116472 0.0002773590 1.823864e-02 4.764958e-02 12 110642249 110642389 141 + 1.993 2.075 0.275
ENSG00000204852 E052 38.6283565 0.0085295273 9.759408e-01 9.889866e-01 12 110643356 110644655 1300 + 1.598 1.600 0.008
ENSG00000204852 E053 6.8526691 0.0023969390 1.827348e-01 3.046256e-01 12 110644656 110644707 52 + 0.971 0.813 -0.602
ENSG00000204852 E054 9.9172714 0.0017528997 5.563588e-01 6.850238e-01 12 110644708 110644879 172 + 1.067 1.008 -0.216
ENSG00000204852 E055 11.2736665 0.0015755358 4.592897e-01 5.994933e-01 12 110644880 110644966 87 + 1.056 1.130 0.267
ENSG00000204852 E056 44.8609094 0.0149436390 1.844582e-01 3.068115e-01 12 110644967 110644972 6 + 1.613 1.713 0.340
ENSG00000204852 E057 59.9481778 0.0006207116 4.913436e-04 2.127479e-03 12 110644973 110644991 19 + 1.704 1.865 0.544
ENSG00000204852 E058 137.8162946 0.0048721471 1.278948e-05 8.288901e-05 12 110644992 110645129 138 + 2.041 2.235 0.650
ENSG00000204852 E059 8.9321976 0.0132477046 8.638247e-01 9.162057e-01 12 110645130 110645143 14 + 1.010 0.991 -0.069
ENSG00000204852 E060 23.3294199 0.0060163834 2.868408e-01 4.272875e-01 12 110645144 110646427 1284 + 1.343 1.427 0.290
ENSG00000204852 E061 5.0102010 0.0033443712 2.704991e-01 4.091603e-01 12 110646428 110646734 307 + 0.848 0.702 -0.584
ENSG00000204852 E062 12.6934907 0.0528140729 3.826656e-01 5.268598e-01 12 110646735 110647195 461 + 1.068 1.213 0.522
ENSG00000204852 E063 8.6448938 0.0179811107 3.670625e-02 8.491600e-02 12 110647196 110647210 15 + 0.849 1.114 0.985
ENSG00000204852 E064 121.9187121 0.0002716163 1.640590e-09 2.337230e-08 12 110647211 110647292 82 + 1.989 2.184 0.650
ENSG00000204852 E065 73.0661373 0.0004287546 8.719553e-10 1.306671e-08 12 110647293 110647300 8 + 1.733 1.989 0.864
ENSG00000204852 E066 83.7657687 0.0003648405 9.082770e-10 1.357129e-08 12 110647301 110647336 36 + 1.801 2.040 0.803
ENSG00000204852 E067 7.2285442 0.0074254035 2.440012e-01 3.789020e-01 12 110647337 110647748 412 + 0.848 0.991 0.539
ENSG00000204852 E068 111.4575661 0.0014929829 6.067927e-10 9.373374e-09 12 110647749 110647893 145 + 1.926 2.160 0.784
ENSG00000204852 E069 58.6456562 0.0015061612 3.442332e-06 2.543743e-05 12 110649043 110649100 58 + 1.654 1.882 0.769
ENSG00000204852 E070 9.2491663 0.0906183230 4.364197e-01 5.784983e-01 12 110649101 110649430 330 + 0.957 1.071 0.419
ENSG00000204852 E071 6.0474112 0.0029777222 3.735861e-01 5.180106e-01 12 110663058 110663431 374 + 0.899 0.788 -0.428