ENSG00000204789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416749 ENSG00000204789 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 8.082674 2.184283 14.12442 0.2769861 0.7545202 2.687391 2.025339 0.0000000 4.516341 0.0000000 0.4692029 8.822202 0.1804958 0.0000000 0.3181000 0.3181 7.770968e-18 7.770968e-18 FALSE TRUE
ENST00000690588 ENSG00000204789 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene processed_transcript 8.082674 2.184283 14.12442 0.2769861 0.7545202 2.687391 3.439244 1.7314822 4.698467 0.1859100 0.3664958 1.434942 0.5502792 0.8012667 0.3328667 -0.4684 1.275881e-06 7.770968e-18 FALSE TRUE
MSTRG.27834.5 ENSG00000204789 HEK293_OSMI2_2hA HEK293_TMG_2hB   transcribed_unprocessed_pseudogene   8.082674 2.184283 14.12442 0.2769861 0.7545202 2.687391 1.706183 0.3109544 2.938240 0.1568262 0.4341048 3.199414 0.1628250 0.1293667 0.2061667 0.0768 6.466735e-01 7.770968e-18   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204789 E001 0.000000       6 27356451 27356516 66 -      
ENSG00000204789 E002 0.737403 0.0156008460 9.374514e-01 9.646585e-01 6 27356517 27357830 1314 - 0.204 0.232 0.230
ENSG00000204789 E003 66.436443 0.0096097710 1.128860e-11 2.330598e-10 6 27357831 27358251 421 - 1.609 2.035 1.436
ENSG00000204789 E004 251.376427 0.0038849008 9.770293e-01 9.896661e-01 6 27358252 27359871 1620 - 2.303 2.329 0.087
ENSG00000204789 E005 12.663730 0.0014215896 4.204466e-01 5.636510e-01 6 27359872 27359879 8 - 1.026 1.137 0.401
ENSG00000204789 E006 18.603463 0.0057100572 8.963879e-01 9.377599e-01 6 27359880 27359952 73 - 1.200 1.236 0.125
ENSG00000204789 E007 49.618383 0.0033863494 2.857443e-05 1.707947e-04 6 27359953 27360221 269 - 1.657 1.373 -0.975
ENSG00000204789 E008 34.296784 0.0006821306 2.461285e-02 6.108059e-02 6 27363179 27363302 124 - 1.481 1.332 -0.517
ENSG00000204789 E009 32.842288 0.0035613122 9.042084e-02 1.757892e-01 6 27367517 27367612 96 - 1.459 1.346 -0.391
ENSG00000204789 E010 29.500175 0.0026118015 4.020741e-02 9.141909e-02 6 27370136 27370224 89 - 1.421 1.270 -0.525
ENSG00000204789 E011 5.245681 0.0041036027 6.871885e-01 7.895839e-01 6 27370225 27370243 19 - 0.691 0.774 0.340
ENSG00000204789 E012 10.742777 0.0018929012 9.922254e-02 1.892935e-01 6 27374550 27375130 581 - 1.020 0.822 -0.746
ENSG00000204789 E013 3.444819 0.1072462713 8.740241e-02 1.711983e-01 6 27375131 27375193 63 - 0.634 0.232 -2.228
ENSG00000204789 E014 19.648255 0.0309774018 6.263976e-02 1.310858e-01 6 27375194 27375347 154 - 1.262 1.039 -0.796