ENSG00000204764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443155 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding retained_intron 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.5823870 0.22132252 1.1861381 0.05143879 0.26756253 2.3704064 0.10662500 0.10390000 0.16163333 0.05773333 0.540789835 0.009263602 FALSE  
ENST00000519256 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding nonsense_mediated_decay 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.2291377 0.03503032 0.6901222 0.03503032 0.15508768 3.9586382 0.03641250 0.01540000 0.09570000 0.08030000 0.079441691 0.009263602 TRUE  
ENST00000520879 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding processed_transcript 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.4938577 0.03161562 0.5499762 0.03161562 0.07190557 3.7501684 0.09809583 0.01390000 0.07506667 0.06116667 0.047334173 0.009263602 FALSE  
ENST00000521165 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding retained_intron 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.1752677 0.22604969 0.2483081 0.12473192 0.14289963 0.1300021 0.03971250 0.10746667 0.03253333 -0.07493333 0.757471264 0.009263602    
ENST00000522066 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding nonsense_mediated_decay 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.3400967 0.06535160 0.5187570 0.04088360 0.15256911 2.8108949 0.06670000 0.02926667 0.07046667 0.04120000 0.524349985 0.009263602 TRUE  
ENST00000522380 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding processed_transcript 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.2860229 0.00000000 0.5028755 0.00000000 0.17409676 5.6805368 0.05265417 0.00000000 0.06750000 0.06750000 0.009263602 0.009263602 FALSE  
ENST00000522533 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding nonsense_mediated_decay 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.3079966 0.22425632 0.3987833 0.12591661 0.25540389 0.8032483 0.08594167 0.10096667 0.05296667 -0.04800000 0.834135032 0.009263602 TRUE  
ENST00000523189 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding protein_coding 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 1.4583541 0.84258659 1.8412450 0.12620905 0.14315317 1.1185776 0.31835833 0.39470000 0.25383333 -0.14086667 0.251591526 0.009263602 FALSE  
ENST00000523727 ENSG00000204764 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP17 protein_coding retained_intron 4.719044 2.153715 7.313809 0.06344209 0.2883321 1.759084 0.4298899 0.40202062 0.3691133 0.10985183 0.18458576 -0.1200876 0.11229167 0.18546667 0.05126667 -0.13420000 0.339872915 0.009263602 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204764 E001 2.0522731 0.0188379584 7.229885e-01 8.169436e-01 5 170861870 170861931 62 + 0.438 0.503 0.326
ENSG00000204764 E002 3.9827568 0.0042678214 7.949718e-01 8.690299e-01 5 170861932 170862017 86 + 0.671 0.631 -0.168
ENSG00000204764 E003 3.1785445 0.0050888304 8.956569e-01 9.373498e-01 5 170862018 170862022 5 + 0.592 0.572 -0.090
ENSG00000204764 E004 4.6315806 0.0035467412 4.208182e-01 5.639976e-01 5 170862023 170862034 12 + 0.752 0.631 -0.506
ENSG00000204764 E005 7.5920184 0.0036290521 1.422283e-02 3.873262e-02 5 170862035 170862051 17 + 0.979 0.631 -1.381
ENSG00000204764 E006 0.1451727 0.0429825533 1.000000e+00   5 170863486 170863685 200 + 0.077 0.000 -10.484
ENSG00000204764 E007 21.4739445 0.0009651107 5.081832e-02 1.106341e-01 5 170878097 170878243 147 + 1.360 1.197 -0.571
ENSG00000204764 E008 17.6155420 0.0025333655 5.276970e-01 6.607269e-01 5 170881806 170881838 33 + 1.252 1.197 -0.195
ENSG00000204764 E009 23.8947375 0.0093072217 2.239977e-01 3.551847e-01 5 170881839 170881896 58 + 1.395 1.289 -0.368
ENSG00000204764 E010 31.1137545 0.0008007410 2.379992e-02 5.940322e-02 5 170892387 170892553 167 + 1.516 1.359 -0.542
ENSG00000204764 E011 18.0453556 0.0010077789 7.502647e-05 4.043566e-04 5 170896050 170896115 66 + 1.334 0.937 -1.427
ENSG00000204764 E012 1.8152964 0.0082487362 1.073947e-02 3.054405e-02 5 170896116 170896238 123 + 0.249 0.683 2.300
ENSG00000204764 E013 22.6264976 0.0008446804 5.500370e-04 2.346911e-03 5 170909661 170909765 105 + 1.412 1.114 -1.047
ENSG00000204764 E014 0.1451727 0.0429825533 1.000000e+00   5 170909766 170910968 1203 + 0.077 0.000 -10.484
ENSG00000204764 E015 16.8569066 0.0011227179 8.740395e-01 9.230247e-01 5 170910969 170911027 59 + 1.223 1.212 -0.039
ENSG00000204764 E016 22.3939692 0.0009416448 1.030099e-01 1.950574e-01 5 170911028 170911134 107 + 1.371 1.240 -0.457
ENSG00000204764 E017 2.7658404 0.0055381927 1.888730e-01 3.123461e-01 5 170911135 170911409 275 + 0.468 0.683 0.980
ENSG00000204764 E018 18.1483779 0.0020489362 1.466997e-02 3.974804e-02 5 170914167 170914240 74 + 1.305 1.076 -0.814
ENSG00000204764 E019 20.3427178 0.0010456075 6.225192e-03 1.920662e-02 5 170916465 170916584 120 + 1.356 1.114 -0.854
ENSG00000204764 E020 2.1285351 0.0578536110 3.232115e-01 4.665317e-01 5 170918171 170918321 151 + 0.522 0.321 -1.088
ENSG00000204764 E021 23.4981360 0.0008508986 5.216676e-03 1.652040e-02 5 170918713 170918859 147 + 1.412 1.182 -0.806
ENSG00000204764 E022 10.6001840 0.0018362759 6.888284e-02 1.415194e-01 5 170919441 170919450 10 + 1.088 0.878 -0.780
ENSG00000204764 E023 26.6536775 0.0008270316 1.169385e-02 3.280565e-02 5 170919451 170919613 163 + 1.458 1.266 -0.667
ENSG00000204764 E024 0.4741261 0.0223846634 7.777024e-01 8.569632e-01 5 170924356 170924356 1 + 0.142 0.189 0.495
ENSG00000204764 E025 35.4858524 0.0006457368 2.805055e-01 4.203604e-01 5 170924357 170924550 194 + 1.543 1.476 -0.229
ENSG00000204764 E026 0.7427016 0.0155750749 1.702333e-01 2.884843e-01 5 170924739 170924918 180 + 0.294 0.000 -12.806
ENSG00000204764 E027 18.9853053 0.0011804825 3.915445e-01 5.354614e-01 5 170953597 170953620 24 + 1.284 1.212 -0.253
ENSG00000204764 E028 23.7874630 0.0008528781 9.098705e-01 9.467241e-01 5 170953621 170953702 82 + 1.364 1.359 -0.018
ENSG00000204764 E029 11.6731150 0.0021728651 6.257514e-01 7.418212e-01 5 170968242 170968255 14 + 1.060 1.114 0.197
ENSG00000204764 E030 23.6337942 0.0008248174 5.917279e-01 7.144246e-01 5 170968256 170968377 122 + 1.345 1.389 0.152
ENSG00000204764 E031 1.1782302 0.0530450288 3.545278e-01 4.988430e-01 5 170968378 170968506 129 + 0.249 0.423 1.086
ENSG00000204764 E032 2.9538770 0.0051233208 9.980142e-01 1.000000e+00 5 170970492 170970658 167 + 0.570 0.572 0.008
ENSG00000204764 E033 4.4593525 0.0236096356 5.178505e-01 6.521783e-01 5 170983065 170983245 181 + 0.738 0.631 -0.449
ENSG00000204764 E034 8.0939519 0.0021673392 9.950088e-01 1.000000e+00 5 171028872 171028989 118 + 0.933 0.937 0.015
ENSG00000204764 E035 0.1472490 0.0433438752 1.000000e+00   5 171029145 171029200 56 + 0.077 0.000 -10.484
ENSG00000204764 E036 0.0000000       5 171143267 171143271 5 +      
ENSG00000204764 E037 0.0000000       5 171143272 171143311 40 +      
ENSG00000204764 E038 0.0000000       5 171143312 171143320 9 +      
ENSG00000204764 E039 0.0000000       5 171143321 171143468 148 +      
ENSG00000204764 E040 0.4502799 0.0263611386 4.057333e-01 5.493847e-01 5 171158334 171158494 161 + 0.199 0.000 -12.070
ENSG00000204764 E041 1.1049644 0.1306279755 3.923427e-01 5.362936e-01 5 171161407 171161466 60 + 0.249 0.420 1.073
ENSG00000204764 E042 18.4026084 0.0010184886 2.279858e-01 3.600283e-01 5 171170130 171170203 74 + 1.223 1.326 0.363
ENSG00000204764 E043 16.6053690 0.0011190745 6.516520e-01 7.624682e-01 5 171171206 171171286 81 + 1.197 1.240 0.153
ENSG00000204764 E044 9.4496967 0.0018371754 5.459569e-01 6.762160e-01 5 171183167 171183194 28 + 1.005 0.937 -0.253
ENSG00000204764 E045 10.6246916 0.0017151637 9.798232e-01 9.914337e-01 5 171183195 171183230 36 + 1.029 1.035 0.020
ENSG00000204764 E046 18.7751061 0.0009492068 4.897022e-01 6.270962e-01 5 171183322 171183430 109 + 1.243 1.303 0.214
ENSG00000204764 E047 18.8908308 0.0566957902 9.465102e-01 9.704268e-01 5 171199670 171199773 104 + 1.253 1.264 0.039
ENSG00000204764 E048 19.5486639 0.0028586826 6.440691e-01 7.564645e-01 5 171205524 171205612 89 + 1.262 1.304 0.147
ENSG00000204764 E049 10.2485273 0.0365282061 1.611722e-01 2.766275e-01 5 171205613 171207903 2291 + 1.068 0.848 -0.824
ENSG00000204764 E050 17.5321127 0.0012672771 1.587369e-01 2.734510e-01 5 171213631 171213738 108 + 1.192 1.315 0.435
ENSG00000204764 E051 18.5646551 0.0063634295 5.732319e-01 6.992049e-01 5 171221758 171221840 83 + 1.238 1.292 0.190
ENSG00000204764 E052 22.3441768 0.0009985821 7.196097e-01 8.143837e-01 5 171240928 171241032 105 + 1.318 1.348 0.108
ENSG00000204764 E053 23.7691493 0.0008480524 3.415167e-01 4.854136e-01 5 171241033 171241142 110 + 1.334 1.408 0.258
ENSG00000204764 E054 26.9859744 0.0320262536 1.268915e-01 2.298198e-01 5 171242682 171242820 139 + 1.357 1.532 0.603
ENSG00000204764 E055 1.1822826 0.0666149429 2.165422e-01 3.462318e-01 5 171242821 171243064 244 + 0.249 0.499 1.473
ENSG00000204764 E056 22.1170499 0.0008780851 9.135133e-03 2.662047e-02 5 171265681 171265847 167 + 1.261 1.460 0.690
ENSG00000204764 E057 0.1482932 0.0411597534 1.673603e-01   5 171271151 171271619 469 + 0.000 0.189 13.194
ENSG00000204764 E058 0.0000000       5 171284513 171284678 166 +      
ENSG00000204764 E059 18.1961146 0.0013319284 8.229035e-05 4.388363e-04 5 171293883 171293981 99 + 1.121 1.444 1.132
ENSG00000204764 E060 20.1300164 0.0009682377 6.448592e-08 6.797231e-07 5 171295887 171296014 128 + 1.121 1.535 1.447
ENSG00000204764 E061 40.7911607 0.0011824766 6.974612e-11 1.263550e-09 5 171298762 171300015 1254 + 1.443 1.808 1.242