ENSG00000204685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432267 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.5884052 1.0046183 0.2313160 0.53778821 0.23131596 -2.071942 0.1413083 0.19656667 0.0796000 -0.11696667 0.611379268 0.002522651 FALSE  
ENST00000446816 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.7718330 1.4955057 0.5278705 0.17658373 0.12954287 -1.484917 0.1891583 0.30070000 0.2154333 -0.08526667 0.630668716 0.002522651 FALSE  
ENST00000614453 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.1531778 0.0000000 0.1462076 0.00000000 0.14620759 3.965393 0.0436500 0.00000000 0.0503000 0.05030000 0.689606996 0.002522651 FALSE  
ENST00000659123 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.2545708 0.2994842 0.2277252 0.12395364 0.11482331 -0.380571 0.0725375 0.06083333 0.0961000 0.03526667 0.950630025 0.002522651 FALSE  
ENST00000665242 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 1.0540339 1.4542228 0.6187026 0.15854793 0.12421568 -1.219685 0.2796083 0.28986667 0.2426000 -0.04726667 0.755461941 0.002522651 FALSE  
ENST00000666290 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA retained_intron 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.6656009 0.3455047 0.7203630 0.34550470 0.07404672 1.038745 0.2025000 0.07233333 0.2879000 0.21556667 0.127658997 0.002522651 FALSE  
ENST00000690896 ENSG00000204685 HEK293_OSMI2_2hA HEK293_TMG_2hB   lncRNA lncRNA 3.783133 4.998743 2.553538 0.111451 0.1814603 -0.9663125 0.2083017 0.2923967 0.0000000 0.07934406 0.00000000 -4.918370 0.0454000 0.05876667 0.0000000 -0.05876667 0.002522651 0.002522651 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204685 E001 1.102886 0.0120061066 0.059696095 0.12610245 2 96208389 96208402 14 + 0.000 0.376 11.118
ENSG00000204685 E002 2.090889 0.0189312613 0.006997490 0.02121657 2 96208403 96208406 4 + 0.000 0.548 13.642
ENSG00000204685 E003 28.072112 0.0068928350 0.188928897 0.31240846 2 96208407 96208653 247 + 1.328 1.448 0.413
ENSG00000204685 E004 38.295914 0.0294912363 0.841464103 0.90112424 2 96208654 96208944 291 + 1.528 1.558 0.105
ENSG00000204685 E005 14.167380 0.0524281267 0.239235060 0.37322422 2 96208945 96208979 35 + 1.256 1.082 -0.620
ENSG00000204685 E006 1.431839 0.0096765512 0.194692676 0.31961546 2 96208980 96209285 306 + 0.165 0.416 1.801
ENSG00000204685 E007 19.790724 0.0017284675 0.025105066 0.06209143 2 96237905 96238099 195 + 1.382 1.221 -0.563
ENSG00000204685 E008 19.158107 0.0010473346 0.681457724 0.78513727 2 96239713 96239831 119 + 1.279 1.260 -0.064
ENSG00000204685 E009 43.702655 0.0005380707 0.146076695 0.25634385 2 96239832 96240238 407 + 1.652 1.590 -0.211
ENSG00000204685 E010 31.459383 0.0042132270 0.014811182 0.04007046 2 96240239 96240443 205 + 1.568 1.420 -0.510
ENSG00000204685 E011 55.636690 0.0005325406 0.164976784 0.28166721 2 96240444 96240688 245 + 1.751 1.702 -0.167
ENSG00000204685 E012 51.587814 0.0019354450 0.811341008 0.88028750 2 96240689 96241876 1188 + 1.665 1.693 0.096
ENSG00000204685 E013 147.031565 0.0049329766 0.005408731 0.01703776 2 96241877 96243353 1477 + 2.045 2.162 0.394