ENSG00000204634

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376840 ENSG00000204634 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D8 protein_coding protein_coding 3.711444 3.568677 3.418941 0.07159086 0.213675 -0.06166307 0.6544907 0.4834901 0.7133168 0.11666037 0.21703210 0.55160635 0.18026250 0.13673333 0.20630000 0.069566667 0.643446501 0.000482441 FALSE TRUE
ENST00000409318 ENSG00000204634 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D8 protein_coding protein_coding 3.711444 3.568677 3.418941 0.07159086 0.213675 -0.06166307 1.3869813 1.3639467 1.3077569 0.14975313 0.12995814 -0.06024184 0.38318750 0.38083333 0.38956667 0.008733333 0.987396939 0.000482441 FALSE TRUE
ENST00000473937 ENSG00000204634 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D8 protein_coding retained_intron 3.711444 3.568677 3.418941 0.07159086 0.213675 -0.06166307 0.2234174 0.1773007 0.1316272 0.06668508 0.08021158 -0.40325818 0.06029583 0.04956667 0.03903333 -0.010533333 0.876999891 0.000482441 FALSE FALSE
ENST00000485875 ENSG00000204634 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D8 protein_coding retained_intron 3.711444 3.568677 3.418941 0.07159086 0.213675 -0.06166307 0.5200451 0.5445504 0.4913958 0.07668639 0.04588761 -0.14536864 0.13154583 0.15213333 0.14320000 -0.008933333 0.941079813 0.000482441 FALSE FALSE
ENST00000494011 ENSG00000204634 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D8 protein_coding retained_intron 3.711444 3.568677 3.418941 0.07159086 0.213675 -0.06166307 0.5205340 0.8157668 0.2754112 0.06647485 0.00995876 -1.53269243 0.13760417 0.22870000 0.08116667 -0.147533333 0.000482441 0.000482441 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204634 E001 24.3957934 0.0083633551 0.274939125 0.414169674 2 101007228 101007616 389 - 1.342 1.435 0.322
ENSG00000204634 E002 41.5302135 0.0040114975 0.241918314 0.376454489 2 101007617 101008273 657 - 1.663 1.599 -0.217
ENSG00000204634 E003 10.6462237 0.0029681662 0.484363988 0.622384810 2 101010929 101011026 98 - 1.091 1.024 -0.247
ENSG00000204634 E004 7.3360578 0.0029811719 0.001434681 0.005421933 2 101011040 101011450 411 - 0.647 1.048 1.564
ENSG00000204634 E005 14.3569048 0.0013261504 0.519621819 0.653696401 2 101011451 101011540 90 - 1.208 1.154 -0.191
ENSG00000204634 E006 15.0724546 0.0012811669 0.139896556 0.247881394 2 101021681 101021746 66 - 1.115 1.247 0.468
ENSG00000204634 E007 27.2193223 0.0007463647 0.839391031 0.899638564 2 101022281 101022521 241 - 1.450 1.439 -0.035
ENSG00000204634 E008 16.9283307 0.0157327822 0.264382375 0.402349262 2 101027383 101027451 69 - 1.306 1.199 -0.376
ENSG00000204634 E009 17.8824731 0.0012279779 0.141873245 0.250598662 2 101028048 101028146 99 - 1.328 1.215 -0.396
ENSG00000204634 E010 11.2781193 0.0015695122 0.634261056 0.748774595 2 101028303 101028344 42 - 1.103 1.060 -0.158
ENSG00000204634 E011 14.3391927 0.0012800637 0.124651708 0.226634792 2 101028345 101028432 88 - 1.091 1.231 0.498
ENSG00000204634 E012 0.1482932 0.0414581950 0.542038183   2 101028467 101028539 73 - 0.000 0.116 8.846
ENSG00000204634 E013 30.2796379 0.0055541255 0.037084125 0.085630590 2 101029491 101029776 286 - 1.393 1.544 0.519
ENSG00000204634 E014 3.7934725 0.0042828211 0.630573934 0.745741228 2 101029777 101029972 196 - 0.710 0.642 -0.283
ENSG00000204634 E015 18.2859396 0.0225575488 0.117703520 0.216667598 2 101032268 101032385 118 - 1.169 1.340 0.602
ENSG00000204634 E016 4.8493216 0.0047326588 0.079918528 0.159435620 2 101032386 101032944 559 - 0.877 0.643 -0.945
ENSG00000204634 E017 26.1625233 0.0347876330 0.783970243 0.861423516 2 101033544 101033758 215 - 1.439 1.421 -0.064
ENSG00000204634 E018 21.4898553 0.0045434201 0.378452812 0.522738705 2 101036018 101036168 151 - 1.299 1.372 0.253
ENSG00000204634 E019 20.3833973 0.0010152503 0.775182341 0.855138145 2 101037532 101037708 177 - 1.335 1.316 -0.065
ENSG00000204634 E020 20.6374900 0.0009162270 0.084020849 0.165833180 2 101038461 101038655 195 - 1.393 1.269 -0.433
ENSG00000204634 E021 18.2270805 0.0018102126 0.101952899 0.193479494 2 101040178 101040385 208 - 1.342 1.215 -0.444
ENSG00000204634 E022 20.8981375 0.0011007996 0.070294313 0.143846775 2 101050401 101050641 241 - 1.399 1.269 -0.454
ENSG00000204634 E023 21.3698784 0.0009839872 0.895379276 0.937180825 2 101054108 101054336 229 - 1.335 1.348 0.044
ENSG00000204634 E024 12.4277030 0.0126370539 0.372355707 0.516822879 2 101059421 101059451 31 - 1.067 1.163 0.346
ENSG00000204634 E025 13.2328880 0.0069172536 0.910584147 0.947156101 2 101059452 101059539 88 - 1.148 1.162 0.049
ENSG00000204634 E026 1.6241419 0.0085875737 0.855673478 0.910762374 2 101090209 101090252 44 - 0.434 0.405 -0.159
ENSG00000204634 E027 1.1770843 0.0111318540 0.823338269 0.888677886 2 101090253 101090253 1 - 0.308 0.349 0.257
ENSG00000204634 E028 7.8788868 0.0317768576 0.481290489 0.619519621 2 101090254 101090364 111 - 0.896 0.993 0.362
ENSG00000204634 E029 0.0000000       2 101109835 101109963 129 -      
ENSG00000204634 E030 7.3372971 0.0025268086 0.936957759 0.964354096 2 101151127 101151382 256 - 0.915 0.908 -0.026
ENSG00000204634 E031 1.4360948 0.0093249802 0.615624851 0.733865470 2 101187824 101187983 160 - 0.434 0.349 -0.481
ENSG00000204634 E032 1.6177992 0.0085393824 0.856089276 0.911050809 2 101187984 101188123 140 - 0.434 0.405 -0.158
ENSG00000204634 E033 0.6287620 0.0180490611 0.907952302 0.945571106 2 101188124 101188233 110 - 0.227 0.208 -0.160
ENSG00000204634 E034 0.7707125 0.0159896131 0.753697185 0.839540385 2 101188234 101188328 95 - 0.227 0.284 0.424
ENSG00000204634 E035 0.1472490 0.0420082612 0.439610478   2 101191301 101191458 158 - 0.128 0.000 -9.441
ENSG00000204634 E036 0.8866386 0.6955063604 0.561245613 0.689110455 2 101195236 101195326 91 - 0.128 0.381 2.033
ENSG00000204634 E037 1.8401894 0.0118058243 0.840621392 0.900525287 2 101252762 101252866 105 - 0.486 0.454 -0.162