ENSG00000204623

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376797 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.25219388 0.19255444 0.17085652 0.053759563 0.04968241 -0.1634642 0.12447083 0.12490000 0.06936667 -0.05553333 0.4956418 0.0217038 FALSE FALSE
ENST00000420251 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.15607794 0.28552248 0.23418901 0.144038928 0.23418901 -0.2752696 0.09261667 0.19866667 0.10660000 -0.09206667 0.5846175 0.0217038 FALSE TRUE
ENST00000425604 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.38035010 0.21383707 0.26907573 0.213837067 0.14166472 0.3182077 0.16578750 0.11660000 0.10690000 -0.00970000 0.7799134 0.0217038 FALSE TRUE
ENST00000431012 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.08179682 0.01290336 0.14052433 0.003790032 0.06006772 2.7163657 0.03554583 0.00810000 0.05903333 0.05093333 0.2061380 0.0217038 FALSE TRUE
ENST00000437417 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.03498237 0.00000000 0.22432282 0.000000000 0.11272508 4.5504255 0.01452917 0.00000000 0.09063333 0.09063333 0.2366663 0.0217038   FALSE
ENST00000444051 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.35684876 0.14330039 0.32709419 0.013232078 0.03116377 1.1367904 0.15606250 0.09213333 0.13650000 0.04436667 0.5234982 0.0217038   FALSE
ENST00000448093 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.08880291 0.08879930 0.00000000 0.058795590 0.00000000 -3.3045008 0.04352500 0.05340000 0.00000000 -0.05340000 0.1008154 0.0217038 FALSE FALSE
ENST00000685581 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene processed_transcript 2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.18692093 0.35580553 0.04562934 0.061804716 0.04562934 -2.7171591 0.08484583 0.23783333 0.02076667 -0.21706667 0.0217038 0.0217038   FALSE
MSTRG.27970.6 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene   2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.30791729 0.17968266 0.68028352 0.179682658 0.04254910 1.8636012 0.13252917 0.09796667 0.28533333 0.18736667 0.2345804 0.0217038   FALSE
MSTRG.27970.9 ENSG00000204623 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNRD1ASP transcribed_unitary_pseudogene   2.181062 1.573884 2.396318 0.1625934 0.2036352 0.6033606 0.10525124 0.04358207 0.00000000 0.043582070 0.00000000 -2.4217503 0.05095417 0.03420000 0.00000000 -0.03420000 0.6934502 0.0217038   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204623 E001 2.4627078 0.006355266 2.208707e-01 3.514767e-01 6 29976042 29977395 1354 - 0.435 0.635 0.946
ENSG00000204623 E002 33.4280090 0.020835235 1.598275e-03 5.955731e-03 6 30001011 30002395 1385 - 1.390 1.663 0.936
ENSG00000204623 E003 11.8425551 0.011490224 4.902932e-01 6.276356e-01 6 30002396 30002660 265 - 1.076 1.153 0.275
ENSG00000204623 E004 6.4288149 0.002661270 6.632789e-01 7.713740e-01 6 30002661 30002732 72 - 0.847 0.903 0.216
ENSG00000204623 E005 2.5035946 0.006872220 4.749678e-01 6.137413e-01 6 30003167 30003368 202 - 0.479 0.597 0.555
ENSG00000204623 E006 1.4371390 0.009731426 4.962130e-01 6.329202e-01 6 30007223 30007396 174 - 0.332 0.454 0.682
ENSG00000204623 E007 0.5953508 0.022493623 8.185635e-01 8.853351e-01 6 30007524 30007543 20 - 0.197 0.239 0.357
ENSG00000204623 E008 0.5953508 0.022493623 8.185635e-01 8.853351e-01 6 30007544 30007559 16 - 0.197 0.239 0.357
ENSG00000204623 E009 1.2178693 0.010864776 1.465872e-01 2.570486e-01 6 30007560 30007642 83 - 0.197 0.454 1.684
ENSG00000204623 E010 1.7984568 0.008583256 2.081272e-02 5.319770e-02 6 30008632 30008674 43 - 0.197 0.597 2.363
ENSG00000204623 E011 2.2883903 0.006814110 1.333449e-01 2.387670e-01 6 30008893 30009125 233 - 0.387 0.635 1.208
ENSG00000204623 E012 2.1347971 0.007004213 5.280524e-03 1.669525e-02 6 30009126 30009171 46 - 0.197 0.671 2.684
ENSG00000204623 E013 1.9617022 0.192618619 9.412972e-01 9.671079e-01 6 30009726 30009831 106 - 0.436 0.467 0.161
ENSG00000204623 E014 0.0000000       6 30012099 30012100 2 -      
ENSG00000204623 E015 25.1797173 0.003045217 1.573094e-05 9.990877e-05 6 30012101 30013557 1457 - 1.247 1.552 1.056
ENSG00000204623 E016 8.8142311 0.072428732 4.493039e-01 5.904910e-01 6 30013558 30014266 709 - 1.043 0.912 -0.488
ENSG00000204623 E017 1.9134431 0.007699544 4.548929e-01 5.954775e-01 6 30014267 30014297 31 - 0.518 0.394 -0.638
ENSG00000204623 E018 10.7530488 0.074375412 5.876939e-01 7.109633e-01 6 30014298 30015957 1660 - 1.107 1.035 -0.264
ENSG00000204623 E019 7.6040303 0.006778822 6.148542e-02 1.291364e-01 6 30015958 30017098 1141 - 1.032 0.815 -0.821
ENSG00000204623 E020 13.6987215 0.001450970 1.432807e-03 5.416253e-03 6 30017099 30019769 2671 - 1.281 0.994 -1.031
ENSG00000204623 E021 2.1185308 0.055559137 1.670691e-01 2.843860e-01 6 30019770 30019924 155 - 0.588 0.326 -1.366
ENSG00000204623 E022 9.0110541 0.002900535 3.822111e-02 8.776712e-02 6 30019925 30021666 1742 - 1.086 0.862 -0.835
ENSG00000204623 E023 10.5093335 0.002098973 1.447131e-01 2.544431e-01 6 30021667 30021761 95 - 0.983 1.132 0.542
ENSG00000204623 E024 6.5656568 0.006574977 6.276146e-01 7.434065e-01 6 30034908 30034934 27 - 0.897 0.840 -0.221
ENSG00000204623 E025 16.4340012 0.001177994 5.558056e-01 6.846096e-01 6 30034935 30035110 176 - 1.261 1.217 -0.153
ENSG00000204623 E026 0.2214452 0.041172502 3.851832e-01   6 30035430 30035915 486 - 0.000 0.137 11.124
ENSG00000204623 E027 8.9659144 0.001978772 9.876969e-02 1.886100e-01 6 30035916 30035983 68 - 1.076 0.903 -0.639
ENSG00000204623 E028 3.9453092 0.128713053 1.209918e-02 3.377271e-02 6 30054601 30056607 2007 - 0.881 0.324 -2.571
ENSG00000204623 E029 1.0510430 0.295815830 2.368290e-01 3.705161e-01 6 30056608 30056948 341 - 0.437 0.134 -2.256
ENSG00000204623 E030 0.4355181 0.733518490 3.874464e-01 5.315760e-01 6 30056949 30056964 16 - 0.268 0.000 -12.200
ENSG00000204623 E031 1.0224378 0.192914072 2.504061e-02 6.195952e-02 6 30056965 30057090 126 - 0.477 0.000 -13.480
ENSG00000204623 E032 3.1228734 0.041547589 1.957851e-04 9.458346e-04 6 30057091 30057717 627 - 0.828 0.136 -3.958
ENSG00000204623 E033 13.7675515 0.001516763 4.511616e-01 5.921438e-01 6 30058115 30058190 76 - 1.194 1.132 -0.223
ENSG00000204623 E034 0.2987644 0.029078516 2.768890e-01   6 30058368 30058747 380 - 0.197 0.000 -11.964
ENSG00000204623 E035 16.3843021 0.001674808 9.263744e-01 9.576286e-01 6 30060741 30060961 221 - 1.240 1.236 -0.011
ENSG00000204623 E036 10.2847191 0.001912133 7.651187e-01 8.479601e-01 6 30060962 30060995 34 - 1.065 1.040 -0.093
ENSG00000204623 E037 5.1034243 0.003453107 9.707485e-01 9.857384e-01 6 30060996 30061078 83 - 0.790 0.790 -0.002
ENSG00000204623 E038 9.8407860 0.002111691 2.226526e-01 3.535568e-01 6 30061079 30061104 26 - 1.096 0.977 -0.438
ENSG00000204623 E039 7.7490747 0.002149064 1.041155e-01 1.967635e-01 6 30061105 30061640 536 - 1.020 0.839 -0.683