ENSG00000204619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376772 ENSG00000204619 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R11 protein_coding protein_coding 48.8298 82.51696 31.27695 3.823941 0.500167 -1.399305 45.6149 79.53885 27.59804 3.748233 0.4570789 -1.526753 0.9190333 0.9638333 0.8823667 -0.08146667 3.526332e-20 3.526332e-20 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204619 E001 5.190512 0.0062339907 6.634532e-09 8.455949e-08 6 30066709 30066861 153 + 1.151 0.417 -3.031
ENSG00000204619 E002 4.358647 0.0036996312 1.323364e-03 5.054582e-03 6 30066862 30067009 148 + 0.949 0.533 -1.709
ENSG00000204619 E003 7.030202 0.0024094760 1.042109e-03 4.104460e-03 6 30067099 30067197 99 + 1.081 0.718 -1.386
ENSG00000204619 E004 5.803899 0.0586639354 2.143505e-02 5.450526e-02 6 30067198 30067204 7 + 0.997 0.653 -1.354
ENSG00000204619 E005 533.554406 0.0007582785 2.554925e-03 8.927182e-03 6 30067205 30067479 275 + 2.672 2.652 -0.064
ENSG00000204619 E006 2.783245 0.0749392573 8.826038e-03 2.584697e-02 6 30067543 30067575 33 + 0.831 0.380 -2.048
ENSG00000204619 E007 7.616110 0.0025728387 4.167579e-10 6.622508e-09 6 30067576 30067625 50 + 1.276 0.604 -2.568
ENSG00000204619 E008 9.070389 0.0019179735 6.204446e-12 1.335590e-10 6 30067626 30067664 39 + 1.343 0.646 -2.621
ENSG00000204619 E009 5.391706 0.0032054297 6.886140e-05 3.745610e-04 6 30068206 30068278 73 + 1.062 0.582 -1.902
ENSG00000204619 E010 13.394308 0.0016155607 6.731475e-05 3.671709e-04 6 30068279 30068353 75 + 1.322 0.985 -1.209
ENSG00000204619 E011 9.987595 0.0028641124 2.090805e-08 2.428402e-07 6 30068354 30068589 236 + 1.322 0.780 -1.992
ENSG00000204619 E012 502.767710 0.0003515813 2.947118e-02 7.091343e-02 6 30068590 30068698 109 + 2.632 2.631 -0.004
ENSG00000204619 E013 2019.155303 0.0015113387 1.713835e-09 2.431702e-08 6 30069104 30070333 1230 + 3.162 3.258 0.318