ENSG00000204592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376630 ENSG00000204592 HEK293_OSMI2_2hA HEK293_TMG_2hB HLA-E protein_coding protein_coding 54.34949 85.10644 41.34377 1.788138 0.8197526 -1.041419 46.639713 77.705845 34.051086 1.4531066 1.1730134 -1.1900844 0.84562917 0.9131333 0.82343333 -0.08970000 0.0006830476 2.109242e-05 FALSE  
ENST00000493699 ENSG00000204592 HEK293_OSMI2_2hA HEK293_TMG_2hB HLA-E protein_coding retained_intron 54.34949 85.10644 41.34377 1.788138 0.8197526 -1.041419 3.781435 3.796714 3.375208 0.3181553 0.4933583 -0.1693017 0.07300833 0.0445000 0.08173333 0.03723333 0.0401728405 2.109242e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204592 E001 2.882709 8.274194e-02 6.217554e-01 0.7386925868 6 30489292 30489497 206 + 0.617 0.530 -0.394
ENSG00000204592 E002 5.845945 5.474133e-02 3.503014e-01 0.4944975949 6 30489498 30489508 11 + 0.892 0.747 -0.567
ENSG00000204592 E003 7.208972 1.693110e-02 5.275567e-01 0.6605947824 6 30489509 30489509 1 + 0.920 0.837 -0.319
ENSG00000204592 E004 7.581933 3.053292e-02 4.816293e-01 0.6198252092 6 30489510 30489511 2 + 0.947 0.849 -0.370
ENSG00000204592 E005 383.079796 1.885912e-03 7.005060e-01 0.7999564076 6 30489512 30489595 84 + 2.524 2.513 -0.037
ENSG00000204592 E006 17.979031 1.053369e-03 5.769200e-01 0.7022705500 6 30489596 30489725 130 + 1.248 1.199 -0.176
ENSG00000204592 E007 860.352085 2.552322e-03 2.084029e-01 0.3365582171 6 30489726 30489995 270 + 2.891 2.859 -0.105
ENSG00000204592 E008 14.343680 1.231102e-03 3.166996e-05 0.0001873643 6 30489996 30490239 244 + 1.370 0.997 -1.332
ENSG00000204592 E009 387.486787 1.952308e-04 7.723459e-01 0.8530404289 6 30490240 30490313 74 + 2.518 2.524 0.019
ENSG00000204592 E010 809.771553 1.137450e-04 8.626381e-01 0.9154289457 6 30490314 30490515 202 + 2.841 2.843 0.008
ENSG00000204592 E011 1175.520541 7.388314e-05 3.237730e-02 0.0765853318 6 30491137 30491412 276 + 3.021 2.997 -0.080
ENSG00000204592 E012 741.312211 1.026725e-04 3.533642e-01 0.4976036916 6 30491537 30491653 117 + 2.793 2.806 0.045
ENSG00000204592 E013 44.276083 1.130884e-02 2.115500e-03 0.0075826819 6 30491985 30492403 419 + 1.751 1.519 -0.791
ENSG00000204592 E014 506.652508 1.204041e-04 3.757986e-01 0.5202028228 6 30492404 30492436 33 + 2.627 2.643 0.052
ENSG00000204592 E015 521.434910 1.204923e-04 4.346050e-03 0.0141116822 6 30492541 30492583 43 + 2.612 2.663 0.170
ENSG00000204592 E016 1898.026366 1.280805e-03 2.425612e-01 0.3771606133 6 30492749 30494194 1446 + 3.198 3.217 0.064