ENSG00000204569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376511 ENSG00000204569 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R10 protein_coding protein_coding 40.96882 66.92933 30.66492 2.527911 0.2122156 -1.125795 33.734498 50.54140 27.9881670 3.845093 0.57489673 -0.8524187 0.84278333 0.7529 0.91256667 0.1596667 1.683202e-04 3.345413e-13 FALSE TRUE
MSTRG.27905.1 ENSG00000204569 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R10 protein_coding   40.96882 66.92933 30.66492 2.527911 0.2122156 -1.125795 4.548434 13.95539 0.6423051 1.704781 0.08166642 -4.4201651 0.08529583 0.2108 0.02096667 -0.1898333 3.345413e-13 3.345413e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204569 E001 13.2584998 0.0397127245 1.405650e-01 2.488145e-01 6 30600295 30600412 118 - 0.933 1.156 0.815
ENSG00000204569 E002 60.1405070 0.0060563281 3.031736e-10 4.929649e-09 6 30600413 30600464 52 - 1.346 1.812 1.591
ENSG00000204569 E003 195.9904443 0.0010909742 5.893115e-13 1.500179e-11 6 30600465 30600492 28 - 2.033 2.288 0.853
ENSG00000204569 E004 611.7166833 0.0047894255 1.262985e-12 3.049564e-11 6 30600493 30600657 165 - 2.510 2.784 0.913
ENSG00000204569 E005 1240.3804185 0.0021855741 1.388683e-20 9.514712e-19 6 30600658 30601097 440 - 2.850 3.084 0.777
ENSG00000204569 E006 572.9458723 0.0013432980 2.349508e-06 1.799476e-05 6 30601098 30601242 145 - 2.609 2.727 0.393
ENSG00000204569 E007 399.1249615 0.0010757686 4.458453e-03 1.442548e-02 6 30601243 30601305 63 - 2.486 2.561 0.249
ENSG00000204569 E008 855.6783553 0.0009332946 1.754206e-08 2.067880e-07 6 30601306 30601658 353 - 2.785 2.899 0.381
ENSG00000204569 E009 599.8464213 0.0005211610 5.473092e-08 5.849379e-07 6 30601936 30602148 213 - 2.634 2.743 0.364
ENSG00000204569 E010 293.1607361 0.0014410869 1.265601e-01 2.293562e-01 6 30602149 30602196 48 - 2.374 2.422 0.158
ENSG00000204569 E011 275.2668998 0.0022943137 4.348428e-01 5.771169e-01 6 30602197 30602244 48 - 2.361 2.390 0.095
ENSG00000204569 E012 327.2288554 0.0035194148 5.307776e-01 6.633141e-01 6 30602245 30602334 90 - 2.439 2.464 0.086
ENSG00000204569 E013 247.8580903 0.0024753503 9.123483e-01 9.484408e-01 6 30602335 30602382 48 - 2.331 2.338 0.022
ENSG00000204569 E014 522.5583388 0.0001237829 1.351684e-03 5.148842e-03 6 30602383 30602691 309 - 2.612 2.671 0.195
ENSG00000204569 E015 355.0212633 0.0001811968 1.916672e-03 6.967033e-03 6 30602846 30602959 114 - 2.436 2.506 0.232
ENSG00000204569 E016 333.3357879 0.0001776045 8.130538e-01 8.814543e-01 6 30603210 30603285 76 - 2.458 2.464 0.020
ENSG00000204569 E017 407.3173022 0.0001255735 2.698033e-01 4.083650e-01 6 30603472 30603572 101 - 2.565 2.544 -0.071
ENSG00000204569 E018 307.7554395 0.0007554402 4.343459e-01 5.767299e-01 6 30603573 30603666 94 - 2.443 2.424 -0.063
ENSG00000204569 E019 2.0585377 0.1117439258 8.102278e-01 8.795574e-01 6 30603667 30603779 113 - 0.401 0.461 0.320
ENSG00000204569 E020 278.6096936 0.0001799995 1.929242e-02 4.996913e-02 6 30603780 30603843 64 - 2.426 2.372 -0.183
ENSG00000204569 E021 560.2172376 0.0001723346 3.425688e-03 1.151297e-02 6 30604008 30604254 247 - 2.723 2.673 -0.165
ENSG00000204569 E022 480.2352146 0.0036584422 2.314520e-02 5.805052e-02 6 30604353 30604511 159 - 2.674 2.602 -0.239
ENSG00000204569 E023 214.6766708 0.0051088110 1.288993e-03 4.939568e-03 6 30604588 30604611 24 - 2.368 2.234 -0.450
ENSG00000204569 E024 371.9616087 0.0027169144 1.314579e-02 3.624554e-02 6 30604612 30604735 124 - 2.565 2.489 -0.253
ENSG00000204569 E025 11.9025434 0.0014959506 1.323606e-05 8.547630e-05 6 30604736 30604993 258 - 1.326 0.910 -1.500
ENSG00000204569 E026 188.5279315 0.0054628023 7.482903e-03 2.246863e-02 6 30604994 30605017 24 - 2.299 2.182 -0.392
ENSG00000204569 E027 242.6222944 0.0041938813 1.486553e-01 2.598454e-01 6 30605018 30605094 77 - 2.367 2.311 -0.189
ENSG00000204569 E028 1.4371390 0.0096765512 3.439960e-01 4.880514e-01 6 30605809 30605922 114 - 0.480 0.311 -0.945
ENSG00000204569 E029 299.2274391 0.0005555082 5.454350e-06 3.849889e-05 6 30605923 30606035 113 - 2.496 2.386 -0.367
ENSG00000204569 E030 308.4711360 0.0043240844 1.059797e-02 3.020451e-02 6 30606138 30606243 106 - 2.500 2.404 -0.318
ENSG00000204569 E031 395.4788747 0.0037794022 1.080632e-04 5.591833e-04 6 30606468 30606641 174 - 2.632 2.501 -0.439
ENSG00000204569 E032 0.1515154 0.0423568265 2.010264e-01   6 30606642 30606737 96 - 0.177 0.000 -10.372
ENSG00000204569 E033 266.0192796 0.0022947970 1.951986e-05 1.214045e-04 6 30606779 30606856 78 - 2.463 2.326 -0.455
ENSG00000204569 E034 240.3341958 0.0019004806 1.816267e-07 1.754736e-06 6 30607840 30607891 52 - 2.438 2.274 -0.547
ENSG00000204569 E035 359.0789212 0.0041474129 3.115303e-06 2.321734e-05 6 30608779 30608914 136 - 2.614 2.446 -0.559
ENSG00000204569 E036 291.3879503 0.0064865007 4.619913e-04 2.014243e-03 6 30609077 30609163 87 - 2.514 2.361 -0.509
ENSG00000204569 E037 309.0779132 0.0041619713 3.857790e-07 3.488029e-06 6 30609838 30609946 109 - 2.562 2.375 -0.624
ENSG00000204569 E038 140.8819308 0.0028512491 1.193581e-10 2.080607e-09 6 30609947 30609955 9 - 2.265 2.009 -0.857
ENSG00000204569 E039 3.1312132 0.0047422690 5.120138e-03 1.625653e-02 6 30614549 30614602 54 - 0.848 0.428 -1.851
ENSG00000204569 E040 240.2259766 0.0057171604 3.127324e-07 2.882607e-06 6 30616478 30616583 106 - 2.473 2.254 -0.733
ENSG00000204569 E041 368.2848455 0.0027461408 7.683213e-09 9.674077e-08 6 30616584 30616998 415 - 2.632 2.453 -0.598
ENSG00000204569 E042 0.9180738 0.1508323358 6.813889e-01 7.850961e-01 6 30617092 30617223 132 - 0.178 0.267 0.753
ENSG00000204569 E043 24.1993077 0.0338436276 1.335529e-03 5.094988e-03 6 30617224 30617280 57 - 1.578 1.214 -1.263
ENSG00000204569 E044 0.0000000       6 30617989 30618035 47 -      
ENSG00000204569 E045 0.3666179 0.0293940316 5.235578e-01 6.572208e-01 6 30618558 30618697 140 - 0.177 0.083 -1.262