ENSG00000204568

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259873 ENSG00000204568 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS18B protein_coding protein_coding 118.1338 213.6651 73.5063 9.793989 1.719438 -1.539283 110.824691 202.990097 66.143119 9.706232 2.3747929 -1.6175993 0.93117500 0.9498667 0.89936667 -0.05050000 0.002719783 0.002719783 FALSE  
MSTRG.27907.3 ENSG00000204568 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPS18B protein_coding   118.1338 213.6651 73.5063 9.793989 1.719438 -1.539283 5.899154 9.621686 5.126417 0.417901 0.4381005 -0.9070259 0.05342083 0.0452000 0.06963333 0.02443333 0.016221555 0.002719783 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204568 E001 3.9042135 4.855073e-03 3.416618e-02 8.007967e-02 6 30617405 30617787 383 + 0.835 0.527 -1.303
ENSG00000204568 E002 2.5549898 7.485674e-02 3.250358e-02 7.681138e-02 6 30617788 30617792 5 + 0.754 0.359 -1.860
ENSG00000204568 E003 23.6759463 3.417595e-03 3.783999e-05 2.194335e-04 6 30617793 30617839 47 + 1.527 1.216 -1.080
ENSG00000204568 E004 32.0322649 6.401742e-04 4.119713e-06 2.986520e-05 6 30617840 30617842 3 + 1.639 1.351 -0.990
ENSG00000204568 E005 53.1244560 5.556945e-03 8.485585e-04 3.432702e-03 6 30617843 30617851 9 + 1.790 1.592 -0.673
ENSG00000204568 E006 174.4267686 5.953748e-04 1.445874e-08 1.730144e-07 6 30617852 30617859 8 + 2.279 2.114 -0.552
ENSG00000204568 E007 658.1273597 1.065920e-03 2.948319e-05 1.757774e-04 6 30617860 30617943 84 + 2.787 2.709 -0.260
ENSG00000204568 E008 1017.0917952 8.501922e-04 1.056105e-05 6.981506e-05 6 30619493 30619601 109 + 2.968 2.901 -0.222
ENSG00000204568 E009 0.5806908 7.940303e-01 8.483287e-02 1.671399e-01 6 30619602 30619680 79 + 0.520 0.000 -13.061
ENSG00000204568 E010 3.1676406 4.836638e-03 7.430945e-01 8.318435e-01 6 30619681 30619708 28 + 0.593 0.549 -0.199
ENSG00000204568 E011 1077.8927670 2.993033e-04 1.564433e-02 4.194470e-02 6 30619709 30619806 98 + 2.958 2.937 -0.069
ENSG00000204568 E012 1.5971752 1.096381e-02 1.984919e-03 7.179429e-03 6 30619807 30619920 114 + 0.706 0.189 -2.906
ENSG00000204568 E013 1047.7897455 9.471103e-05 1.178163e-01 2.168080e-01 6 30619921 30619989 69 + 2.934 2.929 -0.018
ENSG00000204568 E014 2.4986773 2.230037e-01 3.317606e-02 7.815448e-02 6 30619990 30620124 135 + 0.837 0.315 -2.463
ENSG00000204568 E015 760.2366747 1.376262e-04 1.620377e-01 2.777687e-01 6 30622832 30622871 40 + 2.796 2.789 -0.023
ENSG00000204568 E016 672.2299397 1.550242e-03 5.122040e-01 6.471234e-01 6 30622872 30622898 27 + 2.738 2.735 -0.008
ENSG00000204568 E017 1008.0093515 1.670289e-04 1.218514e-01 2.225601e-01 6 30624883 30624942 60 + 2.918 2.911 -0.023
ENSG00000204568 E018 2065.6569747 3.148336e-04 3.097873e-01 4.521264e-01 6 30625502 30625819 318 + 3.203 3.229 0.087
ENSG00000204568 E019 1887.7246702 9.970075e-04 6.390883e-10 9.832970e-09 6 30625820 30626125 306 + 3.090 3.206 0.386
ENSG00000204568 E020 1240.6561502 1.810962e-03 4.217423e-07 3.786806e-06 6 30626126 30626395 270 + 2.895 3.026 0.434