ENSG00000204560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376437 ENSG00000204560 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX16 protein_coding protein_coding 47.50739 65.88153 37.29547 0.5280931 0.7786735 -0.8207058 4.046684 10.3092 0.6002943 3.578089 0.2303979 -4.0796828 0.07597500 0.1565 0.01623333 -0.14026667 3.922894e-03 5.03684e-42 FALSE TRUE
ENST00000376442 ENSG00000204560 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX16 protein_coding protein_coding 47.50739 65.88153 37.29547 0.5280931 0.7786735 -0.8207058 39.545431 52.4777 31.3503293 3.379334 1.3320288 -0.7430386 0.83085833 0.7966 0.83980000 0.04320000 7.948210e-01 5.03684e-42 FALSE TRUE
ENST00000415603 ENSG00000204560 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX16 protein_coding protein_coding 47.50739 65.88153 37.29547 0.5280931 0.7786735 -0.8207058 1.535570 0.0000 2.9794932 0.000000 0.2627358 8.2237571 0.04082083 0.0000 0.07973333 0.07973333 5.036840e-42 5.03684e-42 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204560 E001 3.022582 0.0052594181 3.650139e-01 5.093530e-01 6 30653119 30653126 8 - 0.460 0.617 0.735
ENSG00000204560 E002 187.212199 0.0027056104 6.616240e-05 3.615828e-04 6 30653127 30653248 122 - 2.110 2.271 0.540
ENSG00000204560 E003 298.616214 0.0004906432 1.041448e-08 1.279171e-07 6 30653249 30653289 41 - 2.319 2.470 0.503
ENSG00000204560 E004 402.546047 0.0027531765 4.753901e-07 4.223072e-06 6 30653290 30653370 81 - 2.433 2.603 0.569
ENSG00000204560 E005 718.731089 0.0033094700 2.503285e-05 1.517519e-04 6 30654706 30654879 174 - 2.709 2.847 0.458
ENSG00000204560 E006 315.525237 0.0033021673 3.805804e-03 1.259693e-02 6 30655175 30655183 9 - 2.374 2.485 0.369
ENSG00000204560 E007 576.348196 0.0026632660 9.167716e-05 4.828861e-04 6 30655184 30655336 153 - 2.626 2.747 0.405
ENSG00000204560 E008 534.913203 0.0006910350 4.725353e-07 4.200117e-06 6 30655435 30655597 163 - 2.601 2.713 0.371
ENSG00000204560 E009 360.506702 0.0002628165 1.331406e-03 5.080690e-03 6 30656198 30656265 68 - 2.458 2.532 0.249
ENSG00000204560 E010 461.603763 0.0027449095 9.640173e-02 1.849626e-01 6 30656391 30656509 119 - 2.577 2.635 0.192
ENSG00000204560 E011 543.795629 0.0001190692 4.571318e-03 1.474074e-02 6 30656597 30656759 163 - 2.651 2.704 0.177
ENSG00000204560 E012 492.251764 0.0003195416 5.905584e-01 7.133945e-01 6 30656952 30657092 141 - 2.650 2.644 -0.017
ENSG00000204560 E013 228.689493 0.0038340695 1.918698e-02 4.974294e-02 6 30659472 30659472 1 - 2.373 2.289 -0.280
ENSG00000204560 E014 503.368334 0.0010671520 7.219266e-02 1.469884e-01 6 30659473 30659624 152 - 2.680 2.645 -0.118
ENSG00000204560 E015 1.540381 0.0318234580 2.598633e-01 3.973296e-01 6 30659724 30659735 12 - 0.526 0.326 -1.077
ENSG00000204560 E016 355.683193 0.0003586426 9.598082e-01 9.787269e-01 6 30659736 30659834 99 - 2.500 2.506 0.018
ENSG00000204560 E017 576.223287 0.0001826230 8.847938e-03 2.590190e-02 6 30660032 30660242 211 - 2.741 2.702 -0.129
ENSG00000204560 E018 6.166849 0.0027234661 6.317884e-06 4.396181e-05 6 30660243 30660577 335 - 1.123 0.568 -2.186
ENSG00000204560 E019 4.303197 0.0159791320 4.386911e-01 5.805627e-01 6 30661756 30661983 228 - 0.757 0.642 -0.480
ENSG00000204560 E020 383.391581 0.0007013795 8.032513e-04 3.270721e-03 6 30662627 30662742 116 - 2.587 2.516 -0.238
ENSG00000204560 E021 304.448292 0.0001750992 7.914066e-06 5.381150e-05 6 30662911 30663021 111 - 2.504 2.411 -0.310
ENSG00000204560 E022 394.293244 0.0001807032 1.612751e-04 7.974812e-04 6 30664801 30664992 192 - 2.598 2.528 -0.231
ENSG00000204560 E023 225.870343 0.0002062210 1.390816e-01 2.468114e-01 6 30665071 30665129 59 - 2.333 2.299 -0.113
ENSG00000204560 E024 369.525912 0.0066099975 6.860047e-01 7.885871e-01 6 30665130 30665274 145 - 2.533 2.518 -0.051
ENSG00000204560 E025 602.572052 0.0034800347 9.441738e-02 1.820069e-01 6 30665479 30665733 255 - 2.768 2.721 -0.159
ENSG00000204560 E026 287.968478 0.0019743583 3.243673e-03 1.098349e-02 6 30670410 30670466 57 - 2.474 2.389 -0.284
ENSG00000204560 E027 506.003075 0.0009051300 9.404127e-08 9.597499e-07 6 30670790 30670952 163 - 2.734 2.624 -0.365
ENSG00000204560 E028 509.561458 0.0009501872 7.886276e-13 1.969978e-11 6 30671036 30671274 239 - 2.762 2.613 -0.498
ENSG00000204560 E029 367.352633 0.0082967722 4.242494e-02 9.549203e-02 6 30672635 30672955 321 - 2.583 2.492 -0.302
ENSG00000204560 E030 119.689927 0.0151209516 1.873384e-01 3.103934e-01 6 30672956 30673085 130 - 2.092 2.009 -0.276
ENSG00000204560 E031 1.314870 0.0504914233 1.013928e-01 1.925845e-01 6 30673086 30673189 104 - 0.526 0.224 -1.800