ENSG00000204536

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376266 ENSG00000204536 HEK293_OSMI2_2hA HEK293_TMG_2hB CCHCR1 protein_coding protein_coding 27.73479 42.36075 17.36245 3.123469 0.8655857 -1.286267 18.460270 31.72655 9.691591 1.518175 0.6959375 -1.7098518 0.63250000 0.7520333 0.5569667 -0.19506667 7.835477e-05 2.501611e-06 FALSE TRUE
ENST00000426967 ENSG00000204536 HEK293_OSMI2_2hA HEK293_TMG_2hB CCHCR1 protein_coding protein_coding 27.73479 42.36075 17.36245 3.123469 0.8655857 -1.286267 1.863854 2.62814 1.995877 0.448953 0.2547044 -0.3952884 0.07080417 0.0614000 0.1170333 0.05563333 1.007692e-01 2.501611e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204536 E001 3.3953163 0.0900306053 3.763458e-01 5.206787e-01 6 31142439 31142443 5 - 0.712 0.538 -0.760
ENSG00000204536 E002 5.6815140 0.0920473575 9.619687e-01 9.800248e-01 6 31142444 31142444 1 - 0.759 0.746 -0.056
ENSG00000204536 E003 11.3346750 0.0321121002 8.816943e-01 9.281954e-01 6 31142445 31142451 7 - 0.995 1.009 0.051
ENSG00000204536 E004 52.0361159 0.0033952859 2.044666e-01 3.317567e-01 6 31142452 31142519 68 - 1.564 1.648 0.287
ENSG00000204536 E005 223.6767398 0.0024527873 2.482939e-01 3.839190e-01 6 31142520 31142716 197 - 2.218 2.263 0.148
ENSG00000204536 E006 198.5188158 0.0053583258 1.922475e-01 3.165752e-01 6 31142963 31143059 97 - 2.148 2.215 0.224
ENSG00000204536 E007 130.1286777 0.0073873353 7.990322e-03 2.375430e-02 6 31143060 31143095 36 - 1.890 2.049 0.534
ENSG00000204536 E008 122.1335420 0.0032377738 3.998569e-04 1.773836e-03 6 31143096 31143134 39 - 1.844 2.024 0.606
ENSG00000204536 E009 243.0653374 0.0048654131 2.897716e-03 9.963044e-03 6 31143262 31143413 152 - 2.179 2.313 0.447
ENSG00000204536 E010 8.7524011 0.0019942490 5.165035e-05 2.899690e-04 6 31144520 31144628 109 - 1.216 0.765 -1.679
ENSG00000204536 E011 8.7471595 0.0537290960 8.837005e-02 1.726327e-01 6 31144629 31144686 58 - 1.088 0.824 -0.987
ENSG00000204536 E012 205.4489968 0.0002427666 1.000537e-02 2.877552e-02 6 31144687 31144788 102 - 2.149 2.230 0.268
ENSG00000204536 E013 9.7572050 0.0264883995 7.606778e-04 3.117671e-03 6 31144789 31144884 96 - 1.245 0.816 -1.582
ENSG00000204536 E014 296.1726060 0.0001644791 4.327080e-03 1.406069e-02 6 31144885 31145073 189 - 2.313 2.387 0.245
ENSG00000204536 E015 0.8502072 0.0143041372 4.059577e-01 5.496177e-01 6 31145074 31145115 42 - 0.340 0.186 -1.149
ENSG00000204536 E016 143.0946229 0.0002295436 8.116919e-02 1.613665e-01 6 31145166 31145187 22 - 2.006 2.070 0.215
ENSG00000204536 E017 237.3938364 0.0002367477 7.286602e-02 1.481079e-01 6 31145188 31145302 115 - 2.235 2.287 0.171
ENSG00000204536 E018 149.9187426 0.0003928502 3.941952e-01 5.380785e-01 6 31145448 31145493 46 - 2.054 2.084 0.102
ENSG00000204536 E019 218.8776085 0.0002321125 7.874043e-02 1.574967e-01 6 31145696 31145808 113 - 2.201 2.253 0.174
ENSG00000204536 E020 193.6017467 0.0002161201 2.002027e-02 5.153303e-02 6 31148405 31148511 107 - 2.129 2.203 0.248
ENSG00000204536 E021 220.3713655 0.0006148770 6.038197e-01 7.245033e-01 6 31148618 31148728 111 - 2.234 2.250 0.054
ENSG00000204536 E022 2.2016079 0.1381451656 6.768307e-01 7.816793e-01 6 31148892 31148984 93 - 0.527 0.416 -0.558
ENSG00000204536 E023 1.9447624 0.2780019992 6.118362e-01 7.308864e-01 6 31148985 31148987 3 - 0.527 0.360 -0.872
ENSG00000204536 E024 7.7222152 0.0393744183 2.573309e-04 1.205772e-03 6 31149160 31149668 509 - 1.200 0.681 -1.967
ENSG00000204536 E025 206.9278927 0.0017250590 5.694719e-01 6.960216e-01 6 31150066 31150215 150 - 2.203 2.225 0.074
ENSG00000204536 E026 133.2218118 0.0002847592 4.055282e-01 5.492090e-01 6 31150455 31150501 47 - 2.006 2.037 0.104
ENSG00000204536 E027 137.3497709 0.0002296681 6.435828e-02 1.339671e-01 6 31150502 31150565 64 - 1.985 2.054 0.233
ENSG00000204536 E028 96.5090218 0.0003023724 7.784818e-02 1.560233e-01 6 31150725 31150744 20 - 1.825 1.904 0.267
ENSG00000204536 E029 77.5704653 0.0003332239 3.911813e-01 5.351192e-01 6 31150745 31150747 3 - 1.763 1.805 0.141
ENSG00000204536 E030 163.4086202 0.0002281602 6.082590e-01 7.280466e-01 6 31150748 31150860 113 - 2.103 2.120 0.056
ENSG00000204536 E031 0.0000000       6 31150867 31150884 18 -      
ENSG00000204536 E032 0.0000000       6 31150885 31150958 74 -      
ENSG00000204536 E033 75.1353216 0.0003454556 9.805487e-01 9.918152e-01 6 31150959 31150974 16 - 1.781 1.781 0.002
ENSG00000204536 E034 150.2353765 0.0013389563 1.159384e-01 2.141489e-01 6 31150975 31151069 95 - 2.127 2.068 -0.198
ENSG00000204536 E035 87.2584292 0.0016791584 6.028275e-02 1.270951e-01 6 31151070 31151091 22 - 1.915 1.826 -0.301
ENSG00000204536 E036 92.2685816 0.0003039470 1.620348e-01 2.777683e-01 6 31151092 31151122 31 - 1.919 1.858 -0.205
ENSG00000204536 E037 92.3050477 0.0003260834 2.522506e-01 3.885794e-01 6 31154496 31154530 35 - 1.909 1.859 -0.170
ENSG00000204536 E038 86.2641497 0.0003430599 3.115629e-01 4.540279e-01 6 31154531 31154542 12 - 1.876 1.830 -0.156
ENSG00000204536 E039 99.5509593 0.0013015341 5.677250e-01 6.944869e-01 6 31154543 31154555 13 - 1.922 1.896 -0.087
ENSG00000204536 E040 93.7229973 0.0024287228 9.684578e-01 9.842888e-01 6 31154556 31154571 16 - 1.876 1.875 -0.005
ENSG00000204536 E041 101.1116613 0.0014084257 1.955903e-01 3.207027e-01 6 31154572 31154610 39 - 1.859 1.919 0.203
ENSG00000204536 E042 124.1540964 0.0017592992 1.071870e-01 2.013770e-01 6 31154611 31154673 63 - 1.940 2.011 0.238
ENSG00000204536 E043 87.1436651 0.0039198966 7.275142e-01 8.201841e-01 6 31154674 31154682 9 - 1.829 1.848 0.063
ENSG00000204536 E044 116.7921920 0.0023654754 4.492963e-01 5.904851e-01 6 31154683 31154727 45 - 1.943 1.977 0.115
ENSG00000204536 E045 93.7240844 0.0003993935 5.365448e-01 6.682894e-01 6 31154728 31154741 14 - 1.851 1.879 0.092
ENSG00000204536 E046 153.6660187 0.0002596715 9.791965e-01 9.910506e-01 6 31154742 31154799 58 - 2.089 2.087 -0.005
ENSG00000204536 E047 4.1277074 0.0591279709 2.945736e-01 4.356684e-01 6 31156232 31156730 499 - 0.760 0.572 -0.797
ENSG00000204536 E048 139.7236069 0.0003186998 7.620864e-02 1.534435e-01 6 31156731 31156750 20 - 2.097 2.033 -0.213
ENSG00000204536 E049 214.6328044 0.0008152585 4.725468e-05 2.678552e-04 6 31156751 31156836 86 - 2.328 2.205 -0.411
ENSG00000204536 E050 102.3548696 0.0042350675 1.009334e-04 5.262420e-04 6 31156837 31156837 1 - 2.060 1.870 -0.639
ENSG00000204536 E051 119.8452097 0.0016857731 1.757265e-05 1.103735e-04 6 31156838 31156852 15 - 2.115 1.942 -0.582
ENSG00000204536 E052 191.0140266 0.0019127376 1.328404e-03 5.070358e-03 6 31156853 31156944 92 - 2.270 2.157 -0.377
ENSG00000204536 E053 2.4408362 0.0222490868 3.836130e-01 5.278151e-01 6 31156945 31157022 78 - 0.599 0.444 -0.740
ENSG00000204536 E054 142.8443798 0.0035313411 1.232480e-02 3.431350e-02 6 31157023 31157089 67 - 2.140 2.033 -0.360
ENSG00000204536 E055 12.2848723 0.0015289838 5.154159e-03 1.634893e-02 6 31157090 31157155 66 - 1.246 0.964 -1.018
ENSG00000204536 E056 8.1854440 0.0020236780 5.663645e-06 3.981837e-05 6 31157156 31157357 202 - 1.231 0.723 -1.904
ENSG00000204536 E057 14.5261586 0.0030010850 1.978408e-02 5.102976e-02 6 31157358 31157384 27 - 1.274 1.048 -0.809
ENSG00000204536 E058 24.8634373 0.0212550090 2.227530e-03 7.928734e-03 6 31157385 31157500 116 - 1.543 1.238 -1.057
ENSG00000204536 E059 23.3925734 0.0008301530 9.203514e-07 7.698257e-06 6 31157501 31157802 302 - 1.557 1.189 -1.276
ENSG00000204536 E060 9.2625261 0.0715744288 1.341119e-02 3.687212e-02 6 31157885 31157998 114 - 1.183 0.805 -1.405
ENSG00000204536 E061 6.4590477 0.0384673007 8.617398e-02 1.692751e-01 6 31157999 31158010 12 - 0.969 0.713 -0.998
ENSG00000204536 E062 6.5257683 0.0177580256 2.375946e-01 3.713681e-01 6 31158011 31158166 156 - 0.910 0.740 -0.664
ENSG00000204536 E063 45.4672605 0.0116613000 3.308224e-01 4.743881e-01 6 31158167 31158170 4 - 1.622 1.548 -0.253
ENSG00000204536 E064 44.6671177 0.0030425840 1.232213e-01 2.245643e-01 6 31158171 31158238 68 - 1.635 1.534 -0.345