ENSG00000204438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375893 ENSG00000204438 HEK293_OSMI2_2hA HEK293_TMG_2hB GPANK1 protein_coding protein_coding 20.86811 35.72936 13.37932 1.69861 0.4093717 -1.416431 5.323772 10.560946 2.829117 0.6534766 0.7029676 -1.8965904 0.23458750 0.29523333 0.20860000 -0.08663333 0.429950268 0.009142328 FALSE  
ENST00000375895 ENSG00000204438 HEK293_OSMI2_2hA HEK293_TMG_2hB GPANK1 protein_coding protein_coding 20.86811 35.72936 13.37932 1.69861 0.4093717 -1.416431 10.549085 18.966087 5.692412 1.1704135 0.2046914 -1.7345383 0.49794583 0.53096667 0.42696667 -0.10400000 0.132631441 0.009142328 FALSE  
ENST00000445768 ENSG00000204438 HEK293_OSMI2_2hA HEK293_TMG_2hB GPANK1 protein_coding protein_coding 20.86811 35.72936 13.37932 1.69861 0.4093717 -1.416431 1.091552 1.685181 1.225289 0.1297486 0.3757391 -0.4565903 0.05530000 0.04716667 0.09046667 0.04330000 0.289531401 0.009142328 FALSE  
ENST00000458083 ENSG00000204438 HEK293_OSMI2_2hA HEK293_TMG_2hB GPANK1 protein_coding protein_coding 20.86811 35.72936 13.37932 1.69861 0.4093717 -1.416431 1.881926 1.419053 1.894667 0.7222387 0.4884803 0.4144795 0.10918750 0.03963333 0.14383333 0.10420000 0.147834078 0.009142328 FALSE  
MSTRG.28037.1 ENSG00000204438 HEK293_OSMI2_2hA HEK293_TMG_2hB GPANK1 protein_coding   20.86811 35.72936 13.37932 1.69861 0.4093717 -1.416431 1.413573 2.179238 1.499599 0.2039188 0.1426309 -0.5362640 0.07339583 0.06110000 0.11166667 0.05056667 0.009142328 0.009142328 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204438 E001 4.586910 0.0122947670 1.743032e-01 0.2937831209 6 31661188 31661227 40 - 0.833 0.631 -0.825
ENSG00000204438 E002 3.635538 0.0085356494 3.997769e-01 0.5435102923 6 31661228 31661228 1 - 0.704 0.572 -0.572
ENSG00000204438 E003 22.215817 0.0355279418 1.040521e-02 0.0297589998 6 31661229 31661646 418 - 1.501 1.202 -1.042
ENSG00000204438 E004 8.645122 0.0850064252 4.316438e-02 0.0968457117 6 31661647 31661697 51 - 1.158 0.813 -1.282
ENSG00000204438 E005 8.589737 0.0019910546 4.925076e-04 0.0021315929 6 31661698 31661780 83 - 1.174 0.786 -1.448
ENSG00000204438 E006 18.197246 0.0010665532 4.342648e-03 0.0141025703 6 31661781 31662075 295 - 1.374 1.133 -0.847
ENSG00000204438 E007 501.257329 0.0008258575 7.882988e-05 0.0004224061 6 31662076 31662710 635 - 2.539 2.625 0.286
ENSG00000204438 E008 216.494588 0.0026303259 1.938573e-02 0.0501703291 6 31663853 31663984 132 - 2.171 2.262 0.304
ENSG00000204438 E009 108.209497 0.0003704102 3.254807e-02 0.0768969289 6 31663985 31664022 38 - 1.870 1.964 0.315
ENSG00000204438 E010 247.814120 0.0001711174 3.473729e-01 0.4915797387 6 31664023 31664209 187 - 2.279 2.308 0.096
ENSG00000204438 E011 434.253225 0.0002389586 2.394363e-01 0.3734633063 6 31664210 31664577 368 - 2.558 2.540 -0.059
ENSG00000204438 E012 66.856594 0.0003961114 3.280098e-03 0.0110917579 6 31664578 31664580 3 - 1.842 1.704 -0.465
ENSG00000204438 E013 221.378499 0.0003557120 4.573844e-03 0.0147470326 6 31664841 31665003 163 - 2.308 2.235 -0.243
ENSG00000204438 E014 19.293802 0.0009655759 1.460089e-02 0.0395970894 6 31665090 31665399 310 - 1.374 1.172 -0.708
ENSG00000204438 E015 7.186950 0.0043991929 8.932294e-02 0.1740996335 6 31665400 31665558 159 - 0.987 0.773 -0.821
ENSG00000204438 E016 7.862259 0.0071327110 3.231567e-01 0.4664939625 6 31665559 31665573 15 - 0.960 0.835 -0.476
ENSG00000204438 E017 78.272831 0.0076639529 2.681034e-01 0.4065197071 6 31665574 31665860 287 - 1.745 1.820 0.253
ENSG00000204438 E018 35.445338 0.0006722452 6.532493e-02 0.1355800659 6 31665861 31666283 423 - 1.561 1.444 -0.402