ENSG00000204406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000470063 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.5199407 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.12192083 0.00000000 0.00000000 0.000000000   9.420785e-05 FALSE FALSE
ENST00000473478 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.3909514 0.4346921 0.9042079 0.08619184 0.41301830 1.0397154 0.09463333 0.18233333 0.18830000 0.005966667 9.340908e-01 9.420785e-05 TRUE FALSE
ENST00000478190 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.3482257 0.5891599 0.3605823 0.03374702 0.02628238 -0.6931469 0.10545833 0.24916667 0.07883333 -0.170333333 9.420785e-05 9.420785e-05 FALSE FALSE
ENST00000496158 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.3639031 0.0000000 0.5219387 0.00000000 0.26111554 5.7331882 0.07988750 0.00000000 0.12936667 0.129366667 3.066946e-01 9.420785e-05   FALSE
ENST00000627651 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding protein_coding 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.3864610 0.1800881 0.3175728 0.01998550 0.07767654 0.7851473 0.09992917 0.07576667 0.07280000 -0.002966667 9.443291e-01 9.420785e-05 FALSE TRUE
ENST00000636948 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.1319106 0.0000000 0.7281860 0.00000000 0.72818603 6.2059125 0.02344583 0.00000000 0.12266667 0.122666667 9.176976e-01 9.420785e-05   FALSE
ENST00000637997 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding processed_transcript 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.1866270 0.2943868 0.1363421 0.08303177 0.02385047 -1.0565610 0.06187917 0.12720000 0.02963333 -0.097566667 2.806506e-02 9.420785e-05 TRUE FALSE
ENST00000642680 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding protein_coding 4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.9120662 0.7703224 1.0752131 0.08101879 0.03816366 0.4758361 0.24652500 0.32473333 0.23620000 -0.088533333 3.905318e-01 9.420785e-05 FALSE TRUE
MSTRG.19313.10 ENSG00000204406 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD5 protein_coding   4.054542 2.368118 4.698277 0.09169883 0.6593124 0.9853791 0.1485202 0.0000000 0.2554592 0.00000000 0.25545915 4.7304180 0.03076250 0.00000000 0.06930000 0.069300000 9.428354e-01 9.420785e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204406 E001 0.6955713 0.0164210499 9.699801e-01 9.852118e-01 2 148021011 148021026 16 + 0.221 0.215 -0.055
ENSG00000204406 E002 1.0621892 0.0373072177 9.692412e-01 9.847785e-01 2 148021027 148021046 20 + 0.300 0.293 -0.049
ENSG00000204406 E003 28.4452657 0.0069749723 1.489783e-02 4.025660e-02 2 148021091 148021237 147 + 1.354 1.538 0.636
ENSG00000204406 E004 42.7720263 0.0112796626 1.672609e-03 6.195417e-03 2 148021238 148021392 155 + 1.499 1.727 0.778
ENSG00000204406 E005 21.7746722 0.0164131966 1.327971e-02 3.657008e-02 2 148021393 148021416 24 + 1.212 1.450 0.830
ENSG00000204406 E006 21.4886553 0.0109650843 1.126192e-02 3.178834e-02 2 148021417 148021436 20 + 1.212 1.437 0.788
ENSG00000204406 E007 15.3533246 0.0065396002 2.717477e-02 6.634935e-02 2 148021437 148021442 6 + 1.090 1.296 0.733
ENSG00000204406 E008 13.4324971 0.0122969490 8.100704e-02 1.611168e-01 2 148021443 148021448 6 + 1.053 1.235 0.652
ENSG00000204406 E009 9.8364469 0.0017869734 7.327741e-02 1.487574e-01 2 148021449 148021450 2 + 0.919 1.107 0.692
ENSG00000204406 E010 9.6547425 0.0018187214 9.351184e-02 1.806123e-01 2 148021451 148021454 4 + 0.919 1.096 0.653
ENSG00000204406 E011 14.8053050 0.0013640542 6.941808e-02 1.423921e-01 2 148021455 148021482 28 + 1.101 1.261 0.568
ENSG00000204406 E012 14.3288886 0.0137803274 8.294416e-02 1.641562e-01 2 148021483 148021505 23 + 1.078 1.258 0.645
ENSG00000204406 E013 27.1776993 0.0009251868 8.310157e-03 2.456865e-02 2 148021506 148021592 87 + 1.341 1.517 0.609
ENSG00000204406 E014 20.4212841 0.0009155670 1.588939e-01 2.736755e-01 2 148021593 148021603 11 + 1.262 1.368 0.372
ENSG00000204406 E015 22.1140962 0.0009309323 9.221414e-02 1.785847e-01 2 148021604 148021629 26 + 1.285 1.408 0.428
ENSG00000204406 E016 25.5648221 0.0007576283 5.240977e-02 1.134469e-01 2 148021630 148021647 18 + 1.341 1.473 0.457
ENSG00000204406 E017 32.0349878 0.0007003094 1.272536e-01 2.303067e-01 2 148021648 148021684 37 + 1.461 1.554 0.318
ENSG00000204406 E018 0.0000000       2 148021756 148021782 27 +      
ENSG00000204406 E019 44.7056602 0.0006645114 4.123816e-05 2.369642e-04 2 148024966 148028649 3684 + 1.525 1.742 0.737
ENSG00000204406 E020 0.1451727 0.0432101079 4.722674e-01   2 148041206 148041365 160 + 0.124 0.000 -12.031
ENSG00000204406 E021 2.6540513 0.0359494637 8.561946e-01 9.110826e-01 2 148053933 148054050 118 + 0.522 0.554 0.151
ENSG00000204406 E022 5.6538094 0.0453812445 5.511969e-01 6.807077e-01 2 148054391 148054449 59 + 0.864 0.766 -0.386
ENSG00000204406 E023 0.0000000       2 148054450 148055452 1003 +      
ENSG00000204406 E024 0.4417471 0.6815939480 2.846921e-01 4.249453e-01 2 148055453 148056141 689 + 0.300 0.000 -13.614
ENSG00000204406 E025 0.0000000       2 148068562 148068571 10 +      
ENSG00000204406 E026 0.0000000       2 148068572 148068593 22 +      
ENSG00000204406 E027 5.0362282 0.0043387556 2.943003e-03 1.009676e-02 2 148070873 148072063 1191 + 0.476 0.905 1.819
ENSG00000204406 E028 10.8327183 0.0038539206 5.348872e-02 1.153593e-01 2 148178700 148178793 94 + 1.165 0.968 -0.714
ENSG00000204406 E029 0.0000000       2 148196208 148196235 28 +      
ENSG00000204406 E030 0.0000000       2 148219947 148220033 87 +      
ENSG00000204406 E031 13.2905335 0.0161896224 3.003705e-02 7.203165e-02 2 148233245 148233347 103 + 1.262 1.026 -0.844
ENSG00000204406 E032 9.0674661 0.0623109309 1.538157e-01 2.668598e-01 2 148233348 148233395 48 + 1.101 0.878 -0.827
ENSG00000204406 E033 0.1472490 0.0431926232 4.721309e-01   2 148243711 148244368 658 + 0.124 0.000 -12.032
ENSG00000204406 E034 0.0000000       2 148264179 148265070 892 +      
ENSG00000204406 E035 0.8534295 0.0162887799 6.283418e-01 7.438958e-01 2 148330483 148330505 23 + 0.300 0.215 -0.641
ENSG00000204406 E036 0.1472490 0.0431926232 4.721309e-01   2 148330506 148330600 95 + 0.124 0.000 -12.032
ENSG00000204406 E037 12.0498988 0.0494044759 5.996783e-03 1.860158e-02 2 148342214 148342336 123 + 1.284 0.892 -1.422
ENSG00000204406 E038 0.6234634 0.0188205424 3.334362e-01 4.771646e-01 2 148346022 148347611 1590 + 0.124 0.291 1.525
ENSG00000204406 E039 0.0000000       2 148393301 148393375 75 +      
ENSG00000204406 E040 0.1482932 0.0417672700 5.046193e-01   2 148447567 148447740 174 + 0.000 0.120 11.638
ENSG00000204406 E041 15.0191202 0.0017050954 9.598412e-08 9.777869e-07 2 148458203 148458446 244 + 1.402 0.921 -1.723
ENSG00000204406 E042 19.6713720 0.0039666063 7.252852e-06 4.974589e-05 2 148458447 148458871 425 + 1.475 1.108 -1.289
ENSG00000204406 E043 0.4804688 0.0210075828 5.449048e-01 6.753175e-01 2 148460219 148460291 73 + 0.221 0.120 -1.057
ENSG00000204406 E044 5.7087722 0.0750586761 2.626206e-02 6.447571e-02 2 148462582 148462684 103 + 0.999 0.591 -1.633
ENSG00000204406 E045 10.6156202 0.0016408593 1.487338e-05 9.501340e-05 2 148463739 148463919 181 + 1.254 0.808 -1.643
ENSG00000204406 E046 20.0994681 0.0010527392 1.244057e-07 1.241024e-06 2 148468341 148468724 384 + 1.503 1.096 -1.427
ENSG00000204406 E047 35.8637969 0.0006483415 1.532531e-08 1.824849e-07 2 148468725 148469507 783 + 1.717 1.391 -1.115
ENSG00000204406 E048 44.3146839 0.0017427514 1.873328e-04 9.094077e-04 2 148469508 148470461 954 + 1.752 1.550 -0.686
ENSG00000204406 E049 13.3074490 0.0145495739 2.039483e-01 3.311284e-01 2 148470462 148472455 1994 + 1.078 1.211 0.478
ENSG00000204406 E050 0.1482932 0.0417672700 5.046193e-01   2 148481737 148481792 56 + 0.000 0.120 11.638
ENSG00000204406 E051 12.7823529 0.0106753126 2.035642e-03 7.337257e-03 2 148483110 148483436 327 + 1.277 0.955 -1.159
ENSG00000204406 E052 11.4452705 0.0029270115 9.186793e-03 2.675167e-02 2 148483437 148483814 378 + 1.211 0.953 -0.936
ENSG00000204406 E053 11.2257984 0.0073687816 6.615512e-02 1.369715e-01 2 148483815 148484135 321 + 1.174 0.984 -0.691
ENSG00000204406 E054 0.5869318 0.3517917818 9.592713e-01 9.784579e-01 2 148485116 148485741 626 + 0.221 0.209 -0.101
ENSG00000204406 E055 13.2979444 0.0014761750 1.879216e-02 4.887856e-02 2 148485742 148485950 209 + 1.262 1.049 -0.758
ENSG00000204406 E056 12.3726171 0.0015790973 2.809008e-01 4.207648e-01 2 148489386 148489500 115 + 1.174 1.074 -0.362
ENSG00000204406 E057 51.6381482 0.0006624292 7.900252e-02 1.579158e-01 2 148489501 148490433 933 + 1.757 1.672 -0.287
ENSG00000204406 E058 18.3051799 0.0264983385 2.448722e-01 3.798873e-01 2 148490434 148490594 161 + 1.193 1.327 0.469
ENSG00000204406 E059 0.4396707 0.0290929191 7.917466e-02 1.581932e-01 2 148490595 148490787 193 + 0.300 0.000 -13.616
ENSG00000204406 E060 0.6632174 0.0194437505 3.328550e-01 4.765309e-01 2 148502397 148502435 39 + 0.125 0.291 1.526
ENSG00000204406 E061 9.3466020 0.0018478772 1.096662e-01 2.050770e-01 2 148502436 148502442 7 + 0.902 1.074 0.638
ENSG00000204406 E062 14.6567162 0.0013043062 5.911686e-03 1.837823e-02 2 148502443 148502509 67 + 1.026 1.276 0.893
ENSG00000204406 E063 0.0000000       2 148502965 148502994 30 +      
ENSG00000204406 E064 0.0000000       2 148502995 148503021 27 +      
ENSG00000204406 E065 15.6372602 0.0012351659 6.294886e-03 1.938693e-02 2 148510060 148510135 76 + 1.065 1.304 0.850
ENSG00000204406 E066 0.0000000       2 148512234 148512259 26 +      
ENSG00000204406 E067 42.3605380 0.0005543748 5.904419e-02 1.250013e-01 2 148512870 148516971 4102 + 1.574 1.675 0.341