ENSG00000204356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375429 ENSG00000204356 HEK293_OSMI2_2hA HEK293_TMG_2hB NELFE protein_coding protein_coding 103.976 168.5701 84.18773 19.57807 1.080015 -1.001581 52.878203 99.145069 40.36477 15.1074578 1.3784129 -1.29623248 0.47621250 0.58293333 0.47930000 -0.10363333 3.034797e-02 4.190917e-30 FALSE TRUE
ENST00000441998 ENSG00000204356 HEK293_OSMI2_2hA HEK293_TMG_2hB NELFE protein_coding protein_coding 103.976 168.5701 84.18773 19.57807 1.080015 -1.001581 15.211892 22.118265 15.71334 1.4616099 0.6260001 -0.49298266 0.15213333 0.13296667 0.18663333 0.05366667 7.805227e-03 4.190917e-30 FALSE TRUE
ENST00000444811 ENSG00000204356 HEK293_OSMI2_2hA HEK293_TMG_2hB NELFE protein_coding protein_coding 103.976 168.5701 84.18773 19.57807 1.080015 -1.001581 4.550106 9.252579 0.00000 1.6618806 0.0000000 -9.85527017 0.03964583 0.05500000 0.00000000 -0.05500000 4.190917e-30 4.190917e-30 FALSE TRUE
ENST00000454913 ENSG00000204356 HEK293_OSMI2_2hA HEK293_TMG_2hB NELFE protein_coding protein_coding 103.976 168.5701 84.18773 19.57807 1.080015 -1.001581 17.781243 23.409015 17.16449 0.3354987 0.1475180 -0.44741352 0.18101667 0.14283333 0.20396667 0.06113333 7.932877e-02 4.190917e-30 FALSE FALSE
ENST00000481121 ENSG00000204356 HEK293_OSMI2_2hA HEK293_TMG_2hB NELFE protein_coding retained_intron 103.976 168.5701 84.18773 19.57807 1.080015 -1.001581 8.791919 7.552401 7.11220 0.8077866 0.4243934 -0.08652144 0.10212500 0.04653333 0.08453333 0.03800000 5.406281e-02 4.190917e-30 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204356 E001 0.3697384 2.514102e-02 5.921035e-01 7.147187e-01 6 31945254 31945266 13 - 0.000 0.149 9.740
ENSG00000204356 E002 0.3697384 2.514102e-02 5.921035e-01 7.147187e-01 6 31945267 31945291 25 - 0.000 0.149 11.782
ENSG00000204356 E003 3.6556867 4.241416e-03 9.125508e-02 1.770949e-01 6 31951968 31952086 119 - 0.792 0.538 -1.085
ENSG00000204356 E004 3.2879244 8.687883e-03 6.464766e-02 1.344601e-01 6 31952087 31952091 5 - 0.792 0.510 -1.214
ENSG00000204356 E005 54.0959776 3.375541e-03 4.109381e-02 9.305753e-02 6 31952092 31952226 135 - 1.590 1.718 0.437
ENSG00000204356 E006 42.0084833 6.060915e-04 8.109195e-02 1.612562e-01 6 31952227 31952227 1 - 1.500 1.610 0.375
ENSG00000204356 E007 51.1593406 1.491758e-03 1.596970e-03 5.951433e-03 6 31952228 31952228 1 - 1.514 1.709 0.663
ENSG00000204356 E008 616.2500735 1.062302e-03 1.764901e-07 1.709382e-06 6 31952229 31952398 170 - 2.641 2.758 0.390
ENSG00000204356 E009 540.8592792 9.364376e-04 1.034183e-05 6.851891e-05 6 31953729 31953757 29 - 2.599 2.699 0.331
ENSG00000204356 E010 920.9241018 8.670842e-04 9.743537e-06 6.496388e-05 6 31953758 31953831 74 - 2.843 2.924 0.270
ENSG00000204356 E011 88.3872808 1.766787e-02 8.119354e-04 3.301681e-03 6 31953832 31954079 248 - 2.071 1.805 -0.894
ENSG00000204356 E012 894.7829256 2.506713e-04 1.061363e-04 5.502341e-04 6 31954080 31954134 55 - 2.852 2.909 0.189
ENSG00000204356 E013 605.9622916 1.457090e-04 1.669649e-01 2.842596e-01 6 31954298 31954303 6 - 2.711 2.733 0.075
ENSG00000204356 E014 1043.7743541 7.783518e-05 2.470878e-02 6.127931e-02 6 31954304 31954388 85 - 2.942 2.970 0.091
ENSG00000204356 E015 850.1012648 1.030978e-04 8.199926e-05 4.374564e-04 6 31954389 31954442 54 - 2.831 2.886 0.182
ENSG00000204356 E016 1673.8978440 6.923511e-04 4.747048e-01 6.135187e-01 6 31954555 31954772 218 - 3.162 3.162 0.001
ENSG00000204356 E017 734.7969336 1.931506e-03 3.941967e-01 5.380785e-01 6 31954773 31954802 30 - 2.828 2.797 -0.105
ENSG00000204356 E018 601.9567899 1.041127e-03 1.273805e-01 2.304946e-01 6 31954803 31954819 17 - 2.750 2.710 -0.135
ENSG00000204356 E019 822.3224646 1.294564e-04 8.869274e-02 1.731207e-01 6 31954820 31954877 58 - 2.878 2.853 -0.086
ENSG00000204356 E020 427.8165412 1.285574e-04 5.223994e-01 6.562232e-01 6 31954878 31954892 15 - 2.586 2.573 -0.044
ENSG00000204356 E021 10.9490787 1.577751e-03 3.575547e-04 1.609305e-03 6 31954893 31955058 166 - 1.258 0.900 -1.305
ENSG00000204356 E022 493.8683708 1.123325e-04 1.163253e-01 2.147149e-01 6 31955059 31955064 6 - 2.660 2.631 -0.096
ENSG00000204356 E023 581.6372335 1.116705e-04 7.643811e-02 1.538025e-01 6 31955065 31955083 19 - 2.732 2.702 -0.101
ENSG00000204356 E024 555.2005298 1.256684e-04 6.496719e-01 7.608657e-01 6 31955084 31955096 13 - 2.697 2.688 -0.028
ENSG00000204356 E025 841.4683928 1.666138e-04 1.057442e-01 1.992276e-01 6 31955219 31955293 75 - 2.888 2.864 -0.082
ENSG00000204356 E026 1146.5802401 1.401661e-04 9.949891e-04 3.940664e-03 6 31956693 31956838 146 - 3.034 2.991 -0.143
ENSG00000204356 E027 0.3332198 2.993905e-02 4.992500e-01   6 31956839 31956940 102 - 0.182 0.081 -1.347
ENSG00000204356 E028 745.6279038 1.334970e-03 2.129751e-04 1.019597e-03 6 31956941 31957010 70 - 2.878 2.787 -0.303
ENSG00000204356 E029 0.5503986 2.499891e-02 8.471042e-01 9.050386e-01 6 31957318 31957399 82 - 0.182 0.149 -0.345
ENSG00000204356 E030 0.4782907 2.176816e-02 3.528680e-01 4.971157e-01 6 31957400 31957435 36 - 0.000 0.207 12.405
ENSG00000204356 E031 4.3304346 1.009337e-02 2.010461e-03 7.258510e-03 6 31958308 31958371 64 - 0.969 0.536 -1.768
ENSG00000204356 E032 598.2287749 1.823728e-03 8.768554e-04 3.533140e-03 6 31958372 31958454 83 - 2.786 2.690 -0.318
ENSG00000204356 E033 12.6804461 1.379253e-03 1.965581e-01 3.219358e-01 6 31958455 31958481 27 - 1.177 1.049 -0.460
ENSG00000204356 E034 6.0021526 4.979857e-03 1.166359e-01 2.151561e-01 6 31958482 31958579 98 - 0.944 0.739 -0.797
ENSG00000204356 E035 8.8401114 2.054347e-03 4.238507e-02 9.542157e-02 6 31958580 31958670 91 - 1.094 0.865 -0.853
ENSG00000204356 E036 11.8270057 1.513169e-03 5.489728e-02 1.178177e-01 6 31958671 31958891 221 - 1.191 0.999 -0.696
ENSG00000204356 E037 379.2079070 4.605791e-03 1.028241e-02 2.946250e-02 6 31958892 31959086 195 - 2.599 2.486 -0.374