ENSG00000204237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374741 ENSG00000204237 HEK293_OSMI2_2hA HEK293_TMG_2hB OXLD1 protein_coding protein_coding 50.41574 98.77992 19.89595 6.077411 0.2399904 -2.311164 21.262208 44.504159 7.3986320 1.9336640 0.5563740 -2.586985 0.38060000 0.45293333 0.37253333 -0.08040000 0.3705449 0.01694972 FALSE TRUE
ENST00000571757 ENSG00000204237 HEK293_OSMI2_2hA HEK293_TMG_2hB OXLD1 protein_coding nonsense_mediated_decay 50.41574 98.77992 19.89595 6.077411 0.2399904 -2.311164 3.003942 6.400228 0.8326965 1.2644358 0.3877213 -2.927291 0.05000833 0.06386667 0.04153333 -0.02233333 0.5762619 0.01694972   FALSE
ENST00000575963 ENSG00000204237 HEK293_OSMI2_2hA HEK293_TMG_2hB OXLD1 protein_coding retained_intron 50.41574 98.77992 19.89595 6.077411 0.2399904 -2.311164 15.339863 23.972100 6.4481226 0.8482055 0.3425420 -1.892771 0.35588333 0.24370000 0.32406667 0.08036667 0.0283140 0.01694972   FALSE
ENST00000575992 ENSG00000204237 HEK293_OSMI2_2hA HEK293_TMG_2hB OXLD1 protein_coding nonsense_mediated_decay 50.41574 98.77992 19.89595 6.077411 0.2399904 -2.311164 5.672116 11.345079 3.0815318 0.8187874 0.2426240 -1.876944 0.11137917 0.11473333 0.15520000 0.04046667 0.1206016 0.01694972   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204237 E001 10.93468 0.0106405166 0.511504503 0.64652271 17 81665036 81665055 20 - 0.851 0.942 0.344
ENSG00000204237 E002 76.39864 0.0014399108 0.223305263 0.35433289 17 81665056 81665100 45 - 1.663 1.729 0.226
ENSG00000204237 E003 193.89289 0.0003043046 0.003919128 0.01291571 17 81665101 81665140 40 - 2.029 2.131 0.340
ENSG00000204237 E004 206.12011 0.0002457458 0.003150904 0.01071013 17 81665141 81665155 15 - 2.056 2.157 0.335
ENSG00000204237 E005 719.71433 0.0005323251 0.016599838 0.04406010 17 81665156 81665460 305 - 2.650 2.690 0.134
ENSG00000204237 E006 488.53725 0.0005423563 0.247812083 0.38335869 17 81665461 81665584 124 - 2.497 2.519 0.071
ENSG00000204237 E007 282.36412 0.0010968273 0.038257384 0.08783444 17 81665585 81665997 413 - 2.342 2.272 -0.234
ENSG00000204237 E008 161.86260 0.0002466739 0.089860683 0.17491561 17 81665998 81666145 148 - 2.101 2.030 -0.236
ENSG00000204237 E009 94.03242 0.0003158926 0.807578062 0.87774865 17 81666146 81666149 4 - 1.823 1.804 -0.066
ENSG00000204237 E010 96.03272 0.0003376201 0.695837620 0.79631966 17 81666150 81666154 5 - 1.838 1.811 -0.090
ENSG00000204237 E011 258.91054 0.0002850046 0.006395325 0.01965120 17 81666155 81666276 122 - 2.314 2.227 -0.291
ENSG00000204237 E012 290.15358 0.0062017543 0.023544163 0.05887190 17 81666277 81666517 241 - 2.378 2.276 -0.340
ENSG00000204237 E013 161.68396 0.0075442243 0.573275230 0.69922588 17 81666518 81666635 118 - 2.068 2.034 -0.114
ENSG00000204237 E014 10.49775 0.0161550343 0.494922875 0.63181707 17 81666642 81666669 28 - 0.802 0.904 0.396