ENSG00000204231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374680 ENSG00000204231 HEK293_OSMI2_2hA HEK293_TMG_2hB RXRB protein_coding protein_coding 45.11625 53.25076 32.64958 3.006743 1.268104 -0.7055667 18.674445 28.109669 10.958210 1.2652025 0.07969724 -1.3582515 0.40099167 0.53336667 0.3365333 -0.19683333 1.707451e-02 2.484954e-09 FALSE TRUE
ENST00000374685 ENSG00000204231 HEK293_OSMI2_2hA HEK293_TMG_2hB RXRB protein_coding protein_coding 45.11625 53.25076 32.64958 3.006743 1.268104 -0.7055667 12.015670 16.410221 6.950891 2.4097001 0.54980766 -1.2381296 0.26088333 0.30500000 0.2144000 -0.09060000 1.936012e-01 2.484954e-09 FALSE TRUE
ENST00000481441 ENSG00000204231 HEK293_OSMI2_2hA HEK293_TMG_2hB RXRB protein_coding retained_intron 45.11625 53.25076 32.64958 3.006743 1.268104 -0.7055667 4.693460 2.559519 5.050968 0.5078276 0.46875476 0.9779148 0.10940000 0.04726667 0.1544000 0.10713333 9.323095e-08 2.484954e-09 FALSE TRUE
ENST00000483281 ENSG00000204231 HEK293_OSMI2_2hA HEK293_TMG_2hB RXRB protein_coding nonsense_mediated_decay 45.11625 53.25076 32.64958 3.006743 1.268104 -0.7055667 3.728211 2.225573 4.110963 0.8518806 0.65483736 0.8823367 0.09112917 0.04030000 0.1247000 0.08440000 7.992809e-02 2.484954e-09 FALSE TRUE
ENST00000483821 ENSG00000204231 HEK293_OSMI2_2hA HEK293_TMG_2hB RXRB protein_coding retained_intron 45.11625 53.25076 32.64958 3.006743 1.268104 -0.7055667 5.312387 3.212976 5.234080 0.2837459 0.52810064 0.7022963 0.12253333 0.06030000 0.1596667 0.09936667 2.484954e-09 2.484954e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204231 E001 732.255799 0.0004644544 4.390720e-21 3.198034e-19 6 33193588 33194219 632 - 2.690 2.848 0.528
ENSG00000204231 E002 436.813072 0.0004321042 1.317086e-04 6.663767e-04 6 33194220 33194342 123 - 2.531 2.606 0.250
ENSG00000204231 E003 737.355261 0.0005784648 1.881423e-02 4.892587e-02 6 33194343 33194663 321 - 2.786 2.823 0.123
ENSG00000204231 E004 456.167873 0.0001802886 8.283206e-02 1.639836e-01 6 33194664 33194829 166 - 2.585 2.613 0.092
ENSG00000204231 E005 357.444581 0.0001700681 7.773307e-05 4.173529e-04 6 33194945 33195050 106 - 2.440 2.519 0.264
ENSG00000204231 E006 52.584715 0.0008432335 1.371987e-27 1.880745e-25 6 33195051 33195360 310 - 1.993 1.449 -1.845
ENSG00000204231 E007 334.117877 0.0001946662 4.563477e-01 5.967921e-01 6 33195363 33195454 92 - 2.463 2.474 0.037
ENSG00000204231 E008 82.830470 0.0008409378 2.032913e-02 5.217627e-02 6 33195455 33195466 12 - 1.938 1.833 -0.353
ENSG00000204231 E009 427.353101 0.0002482871 9.084991e-01 9.458701e-01 6 33195570 33195702 133 - 2.579 2.577 -0.008
ENSG00000204231 E010 43.984196 0.0009420312 7.849070e-34 1.766013e-31 6 33195785 33195906 122 - 1.968 1.311 -2.239
ENSG00000204231 E011 342.785388 0.0001514481 4.466203e-01 5.881106e-01 6 33195907 33196036 130 - 2.473 2.484 0.037
ENSG00000204231 E012 55.508928 0.0130245571 2.206854e-14 6.901318e-13 6 33196037 33196433 397 - 2.022 1.465 -1.886
ENSG00000204231 E013 337.412657 0.0008034212 1.224366e-01 2.234178e-01 6 33196434 33196606 173 - 2.502 2.461 -0.138
ENSG00000204231 E014 352.366252 0.0004769262 8.402107e-03 2.479445e-02 6 33197762 33197941 180 - 2.536 2.473 -0.209
ENSG00000204231 E015 223.156821 0.0017001577 6.122847e-01 7.312423e-01 6 33198308 33198361 54 - 2.309 2.288 -0.067
ENSG00000204231 E016 212.780668 0.0071813748 3.580607e-01 5.024485e-01 6 33198362 33198464 103 - 2.308 2.262 -0.153
ENSG00000204231 E017 24.915299 0.0052040216 1.956037e-11 3.883112e-10 6 33198465 33198635 171 - 1.663 1.148 -1.786
ENSG00000204231 E018 102.553879 0.0061793045 2.694484e-01 4.079614e-01 6 33199169 33199248 80 - 2.003 1.941 -0.209
ENSG00000204231 E019 71.393649 0.0004875952 4.979882e-01 6.345074e-01 6 33199249 33199416 168 - 1.826 1.790 -0.122
ENSG00000204231 E020 225.755705 0.0032488814 1.375071e-05 8.844704e-05 6 33200242 33200665 424 - 2.411 2.250 -0.536
ENSG00000204231 E021 3.659864 0.0054287259 5.932182e-01 7.156538e-01 6 33200767 33200809 43 - 0.691 0.605 -0.370