ENSG00000204160

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374141 ENSG00000204160 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC18 protein_coding protein_coding 35.36145 48.99075 29.72745 2.195224 0.6781305 -0.7205228 27.072504 42.908272 17.321165 1.6429733 0.5087196 -1.308223 0.74422500 0.87646667 0.58403333 -0.2924333 1.062064e-13 7.293017e-42 FALSE TRUE
ENST00000534643 ENSG00000204160 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC18 protein_coding protein_coding 35.36145 48.99075 29.72745 2.195224 0.6781305 -0.7205228 2.903071 0.000000 7.986840 0.0000000 1.0309435 9.643286 0.10035000 0.00000000 0.26736667 0.2673667 7.293017e-42 7.293017e-42 FALSE FALSE
MSTRG.622.2 ENSG00000204160 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC18 protein_coding   35.36145 48.99075 29.72745 2.195224 0.6781305 -0.7205228 2.790276 3.922279 1.952984 0.5222919 0.2238400 -1.002317 0.07901667 0.07943333 0.06573333 -0.0137000 6.643681e-01 7.293017e-42 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204160 E001 21.110553 0.0393162806 2.043252e-05 1.264704e-04 1 26826688 26826946 259 + 1.549 1.123 -1.485
ENSG00000204160 E002 108.745494 0.0011293171 7.818076e-07 6.644435e-06 1 26826947 26827139 193 + 2.075 1.965 -0.369
ENSG00000204160 E003 0.000000       1 26832004 26832019 16 +      
ENSG00000204160 E004 0.000000       1 26832020 26832053 34 +      
ENSG00000204160 E005 0.000000       1 26832054 26832072 19 +      
ENSG00000204160 E006 253.490258 0.0036044272 9.867767e-06 6.568584e-05 1 26832447 26832607 161 + 2.423 2.345 -0.260
ENSG00000204160 E007 339.501254 0.0022368259 2.693298e-07 2.516459e-06 1 26848608 26848757 150 + 2.543 2.475 -0.229
ENSG00000204160 E008 247.352483 0.0016372542 3.157346e-04 1.443725e-03 1 26850301 26850361 61 + 2.379 2.351 -0.093
ENSG00000204160 E009 268.099734 0.0029389739 2.086258e-04 1.000874e-03 1 26850362 26850438 77 + 2.425 2.382 -0.145
ENSG00000204160 E010 240.574255 0.0007518373 2.691588e-05 1.619338e-04 1 26850558 26850606 49 + 2.371 2.337 -0.111
ENSG00000204160 E011 293.195184 0.0005622980 2.325268e-04 1.102114e-03 1 26851129 26851231 103 + 2.439 2.430 -0.031
ENSG00000204160 E012 320.793467 0.0001571037 2.362476e-03 8.345249e-03 1 26852753 26852865 113 + 2.462 2.476 0.046
ENSG00000204160 E013 11.779303 0.0189101128 2.689628e-02 6.577705e-02 1 26852866 26853211 346 + 1.198 1.019 -0.647
ENSG00000204160 E014 312.996983 0.0001508047 1.430086e-01 2.521292e-01 1 26853726 26853825 100 + 2.430 2.476 0.155
ENSG00000204160 E015 2442.111771 0.0041770339 3.529130e-12 7.915974e-11 1 26853826 26856184 2359 + 3.204 3.412 0.693
ENSG00000204160 E016 4.388749 0.0091780928 5.511415e-02 1.181941e-01 1 26856185 26856262 78 + 0.850 0.644 -0.839
ENSG00000204160 E017 8.112275 0.0020612681 1.136727e-01 2.108789e-01 1 26856263 26856847 585 + 1.005 0.893 -0.420
ENSG00000204160 E018 15.316598 0.0011795838 8.948758e-01 9.368143e-01 1 26856848 26857604 757 + 1.134 1.194 0.215