ENSG00000204130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466187 ENSG00000204130 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY2 protein_coding retained_intron 4.267681 1.639747 6.419908 0.2020616 0.259694 1.962553 0.1491564 0.21933685 0.04009499 0.19449460 0.02528881 -2.194730 0.06105833 0.14856667 0.0060000 -0.14256667 0.3309812676 0.0005668493   FALSE
ENST00000473398 ENSG00000204130 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY2 protein_coding retained_intron 4.267681 1.639747 6.419908 0.2020616 0.259694 1.962553 0.3747160 0.03456744 0.53253662 0.03456744 0.10276228 3.605659 0.08470417 0.02476667 0.0821000 0.05733333 0.1021350855 0.0005668493   FALSE
ENST00000602465 ENSG00000204130 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY2 protein_coding protein_coding 4.267681 1.639747 6.419908 0.2020616 0.259694 1.962553 2.4372772 1.17212689 3.37916116 0.20095711 0.34911757 1.519543 0.59450417 0.71170000 0.5323000 -0.17940000 0.3762150860 0.0005668493 FALSE TRUE
MSTRG.4078.7 ENSG00000204130 HEK293_OSMI2_2hA HEK293_TMG_2hB RUFY2 protein_coding   4.267681 1.639747 6.419908 0.2020616 0.259694 1.962553 0.8987037 0.06186360 1.67170237 0.03094049 0.32319981 4.548517 0.16204583 0.03723333 0.2573333 0.22010000 0.0005668493 0.0005668493 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204130 E001 0.0000000       10 68341107 68341129 23 -      
ENSG00000204130 E002 0.0000000       10 68341130 68341152 23 -      
ENSG00000204130 E003 1.4843564 0.0186556420 9.684825e-01 0.9842980486 10 68341153 68341288 136 - 0.320 0.373 0.320
ENSG00000204130 E004 0.1451727 0.0428545599 1.000000e+00   10 68343406 68343407 2 - 0.063 0.000 -9.409
ENSG00000204130 E005 2.1714175 0.0071872904 9.643816e-05 0.0005053221 10 68343408 68343518 111 - 0.167 0.853 3.711
ENSG00000204130 E006 122.7656061 0.0439672000 4.043137e-05 0.0002327510 10 68343519 68345144 1626 - 1.869 2.310 1.476
ENSG00000204130 E007 49.7665661 0.0004679235 4.833725e-01 0.6213847084 10 68345145 68345701 557 - 1.610 1.648 0.130
ENSG00000204130 E008 14.7118865 0.0038279672 7.447624e-01 0.8329771685 10 68345702 68345732 31 - 1.103 1.144 0.145
ENSG00000204130 E009 26.6812397 0.0007841426 8.820171e-01 0.9284268827 10 68345733 68345830 98 - 1.340 1.428 0.305
ENSG00000204130 E010 24.6206915 0.0009362580 3.463485e-01 0.4904927507 10 68345831 68345911 81 - 1.331 1.330 -0.003
ENSG00000204130 E011 22.6930604 0.0008638823 8.757145e-01 0.9241701510 10 68346007 68346084 78 - 1.281 1.344 0.220
ENSG00000204130 E012 1.0622038 0.1253596723 6.549472e-01 0.7649772574 10 68346085 68346724 640 - 0.250 0.371 0.796
ENSG00000204130 E013 17.5528732 0.0011161980 3.978077e-01 0.5415715358 10 68355353 68355401 49 - 1.190 1.184 -0.023
ENSG00000204130 E014 1.7995948 0.0081382645 2.196067e-01 0.3499060733 10 68355402 68355698 297 - 0.434 0.225 -1.335
ENSG00000204130 E015 25.0355506 0.0008073411 8.184125e-01 0.8852223021 10 68363590 68363684 95 - 1.311 1.406 0.328
ENSG00000204130 E016 28.3452001 0.0326153692 9.669408e-01 0.9832767328 10 68363984 68364113 130 - 1.369 1.442 0.252
ENSG00000204130 E017 27.3993044 0.0615611725 2.891200e-01 0.4298005353 10 68376853 68376972 120 - 1.381 1.328 -0.183
ENSG00000204130 E018 5.3549770 0.0821507936 2.411440e-01 0.3755302017 10 68376973 68377015 43 - 0.765 0.574 -0.807
ENSG00000204130 E019 1.0373134 0.0117283575 1.317796e-01 0.2366007042 10 68377016 68377192 177 - 0.320 0.000 -12.217
ENSG00000204130 E020 0.2966881 0.0290785164 1.000000e+00   10 68377193 68377193 1 - 0.118 0.000 -10.410
ENSG00000204130 E021 3.0678166 0.0048901955 4.563403e-01 0.5967907526 10 68377194 68378670 1477 - 0.562 0.483 -0.379
ENSG00000204130 E022 0.0000000       10 68379135 68379423 289 -      
ENSG00000204130 E023 18.4988013 0.0789200311 1.802187e-01 0.3014523183 10 68379424 68379492 69 - 1.228 1.114 -0.406
ENSG00000204130 E024 14.5995876 0.0020752713 2.918056e-01 0.4327232241 10 68379493 68379521 29 - 1.114 1.075 -0.141
ENSG00000204130 E025 29.4009593 0.0213876299 1.220397e-02 0.0340201022 10 68381232 68381399 168 - 1.432 1.243 -0.661
ENSG00000204130 E026 24.3987339 0.0055670181 2.748686e-03 0.0095170370 10 68383798 68383914 117 - 1.359 1.144 -0.755
ENSG00000204130 E027 22.3429190 0.0116929170 1.934471e-01 0.3181053902 10 68384051 68384152 102 - 1.295 1.240 -0.192
ENSG00000204130 E028 18.1357157 0.0312510135 9.621641e-01 0.9801333930 10 68386059 68386128 70 - 1.178 1.261 0.293
ENSG00000204130 E029 14.8982582 0.0033638273 3.488725e-01 0.4930903821 10 68393138 68393203 66 - 1.070 1.239 0.603
ENSG00000204130 E030 0.0000000       10 68393764 68394074 311 -      
ENSG00000204130 E031 14.3499280 0.0014718269 3.127902e-01 0.4553200032 10 68394075 68394136 62 - 1.109 1.075 -0.124
ENSG00000204130 E032 24.3604500 0.0078502986 3.576383e-03 0.0119456804 10 68394328 68394451 124 - 1.358 1.145 -0.753
ENSG00000204130 E033 21.5478602 0.0008284948 4.941344e-04 0.0021376570 10 68396780 68396881 102 - 1.318 1.049 -0.958
ENSG00000204130 E034 25.2894620 0.0222061764 1.648267e-01 0.2814668067 10 68401620 68401737 118 - 1.355 1.272 -0.290
ENSG00000204130 E035 19.6526825 0.0067193035 2.380380e-02 0.0594112650 10 68404671 68404844 174 - 1.262 1.100 -0.579
ENSG00000204130 E036 0.7322062 0.2455131127 3.589836e-01 0.5033182726 10 68406754 68406905 152 - 0.250 0.000 -11.727
ENSG00000204130 E037 0.4355181 0.5853569147 8.760168e-01 0.9243810921 10 68406906 68407185 280 - 0.166 0.000 -10.985
ENSG00000204130 E038 7.0143684 0.0848783613 2.990561e-01 0.4405371969 10 68407186 68407294 109 - 0.858 0.709 -0.595