ENSG00000204084

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373024 ENSG00000204084 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5B protein_coding protein_coding 7.809417 8.063319 7.077911 0.604631 0.1681855 -0.1878013 2.122364 1.94859179 2.240636 0.04912112 0.09137259 0.2005158 0.27407500 0.244333333 0.3168000 0.07246667 1.983396e-01 1.464498e-13 FALSE TRUE
ENST00000373027 ENSG00000204084 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5B protein_coding protein_coding 7.809417 8.063319 7.077911 0.604631 0.1681855 -0.1878013 4.486821 5.74680241 3.610073 0.66516947 0.15527731 -0.6692488 0.56891250 0.708066667 0.5096000 -0.19846667 1.152139e-03 1.464498e-13 FALSE TRUE
MSTRG.880.5 ENSG00000204084 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5B protein_coding   7.809417 8.063319 7.077911 0.604631 0.1681855 -0.1878013 0.676267 0.06683075 1.143619 0.04441725 0.03804659 3.9083391 0.08925833 0.009266667 0.1615667 0.15230000 1.464498e-13 1.464498e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000204084 E001 269.7641865 0.0081637552 3.191135e-12 7.215073e-11 1 37860697 37862067 1371 - 2.208 2.545 1.126
ENSG00000204084 E002 95.8338918 0.0003329958 2.580860e-06 1.960648e-05 1 37862068 37862339 272 - 1.854 2.063 0.703
ENSG00000204084 E003 61.8213836 0.0005736746 1.128577e-03 4.399745e-03 1 37862340 37862430 91 - 1.687 1.873 0.627
ENSG00000204084 E004 67.8076688 0.0003713301 4.900178e-03 1.565154e-02 1 37864312 37864423 112 - 1.741 1.900 0.533
ENSG00000204084 E005 0.9244034 0.0156115872 2.354373e-01 3.688842e-01 1 37864424 37864849 426 - 0.127 0.351 1.872
ENSG00000204084 E006 66.7235208 0.0005527174 6.824120e-01 7.858496e-01 1 37865761 37865888 128 - 1.801 1.856 0.185
ENSG00000204084 E007 58.3233189 0.0004205859 8.716924e-01 9.214757e-01 1 37866459 37866543 85 - 1.749 1.794 0.151
ENSG00000204084 E008 68.2830311 0.0060195003 7.087261e-01 8.063106e-01 1 37868501 37868614 114 - 1.831 1.843 0.041
ENSG00000204084 E009 1.7703588 0.0079718764 9.957512e-01 1.000000e+00 1 37869925 37870014 90 - 0.432 0.457 0.132
ENSG00000204084 E010 0.1482932 0.0411575139 5.654563e-01   1 37870670 37870720 51 - 0.000 0.117 9.994
ENSG00000204084 E011 91.3522695 0.0039500643 7.527828e-01 8.388770e-01 1 37872930 37873165 236 - 1.952 1.972 0.068
ENSG00000204084 E012 0.1817044 0.0397816330 5.631104e-01   1 37873166 37873387 222 - 0.000 0.118 9.999
ENSG00000204084 E013 70.2053589 0.0028890832 9.505547e-01 9.730504e-01 1 37873993 37874155 163 - 1.833 1.867 0.114
ENSG00000204084 E014 59.2263272 0.0016994199 3.535043e-01 4.977505e-01 1 37875606 37875716 111 - 1.785 1.778 -0.023
ENSG00000204084 E015 65.9197370 0.0004379976 2.749137e-01 4.141419e-01 1 37878188 37878323 136 - 1.831 1.821 -0.032
ENSG00000204084 E016 58.1260844 0.0004270687 8.399738e-02 1.658041e-01 1 37880085 37880194 110 - 1.794 1.753 -0.139
ENSG00000204084 E017 51.3612165 0.0006448919 5.966571e-04 2.521356e-03 1 37882807 37882918 112 - 1.785 1.655 -0.440
ENSG00000204084 E018 0.2965864 0.1207789864 2.822321e-01   1 37885509 37885637 129 - 0.000 0.208 10.979
ENSG00000204084 E019 63.6843565 0.0005330315 3.805749e-06 2.782984e-05 1 37885638 37885825 188 - 1.894 1.729 -0.556
ENSG00000204084 E020 47.5055119 0.0085637956 1.880880e-02 4.891338e-02 1 37886888 37887004 117 - 1.749 1.629 -0.408
ENSG00000204084 E021 45.0948462 0.0006582281 8.382227e-03 2.474426e-02 1 37887351 37887465 115 - 1.717 1.617 -0.337
ENSG00000204084 E022 47.9170709 0.0005241802 1.354755e-04 6.833182e-04 1 37888243 37888344 102 - 1.770 1.617 -0.518
ENSG00000204084 E023 56.6793474 0.0007009113 2.943508e-07 2.728708e-06 1 37889557 37889724 168 - 1.862 1.661 -0.682
ENSG00000204084 E024 36.1024170 0.0006242775 4.349238e-09 5.728639e-08 1 37891358 37891454 97 - 1.714 1.413 -1.028
ENSG00000204084 E025 0.7426990 0.0967352793 4.139127e-01 5.573250e-01 1 37928537 37931672 3136 - 0.127 0.288 1.465
ENSG00000204084 E026 15.8540049 0.0011676363 7.867510e-03 2.344807e-02 1 37931673 37931912 240 - 1.324 1.138 -0.656
ENSG00000204084 E027 17.5232749 0.0010343646 1.448418e-03 5.468175e-03 1 37931913 37932053 141 - 1.377 1.158 -0.770
ENSG00000204084 E028 15.3776862 0.0011424883 6.168993e-02 1.294726e-01 1 37940688 37940762 75 - 1.280 1.157 -0.432
ENSG00000204084 E029 9.3344433 0.0020242615 1.152392e-01 2.132024e-01 1 37940763 37940798 36 - 1.088 0.958 -0.475
ENSG00000204084 E030 1.4716815 0.0906665226 6.465154e-01 7.583980e-01 1 37942083 37942264 182 - 0.306 0.413 0.635
ENSG00000204084 E031 8.9164142 0.0020028613 6.051775e-01 7.255948e-01 1 37943640 37943669 30 - 1.008 0.987 -0.078
ENSG00000204084 E032 11.6827104 0.0021497218 7.539063e-02 1.521441e-01 1 37943796 37943893 98 - 1.175 1.039 -0.489
ENSG00000204084 E033 13.8538534 0.0012745541 2.151694e-02 5.467901e-02 1 37945756 37945850 95 - 1.256 1.086 -0.604
ENSG00000204084 E034 12.6843330 0.0060873963 2.497553e-03 8.755949e-03 1 37946252 37946334 83 - 1.256 0.988 -0.963
ENSG00000204084 E035 8.5649112 0.0225434248 5.865125e-02 1.243209e-01 1 37946990 37947057 68 - 1.075 0.862 -0.796