ENSG00000203995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371528 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding protein_coding 4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 2.7292871 1.95540379 2.8384530 0.17409723 0.38766648 0.5353529 0.59187917 0.694700000 0.48363333 -0.21106667 0.0882818431 0.0001774749 FALSE TRUE
ENST00000371532 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding protein_coding 4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 0.3190404 0.24332057 0.4118776 0.06512402 0.23879155 0.7358602 0.07754583 0.084933333 0.07173333 -0.01320000 0.7854007175 0.0001774749 FALSE TRUE
MSTRG.1204.10 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding   4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 0.5475166 0.19794587 0.5869840 0.04938446 0.05639444 1.5214842 0.10425000 0.069766667 0.10033333 0.03056667 0.5494515396 0.0001774749 TRUE TRUE
MSTRG.1204.3 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding   4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 0.4781091 0.10996738 0.3877434 0.10996738 0.21031041 1.7291958 0.08948750 0.033866667 0.06556667 0.03170000 0.7636413676 0.0001774749 FALSE TRUE
MSTRG.1204.4 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding   4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 0.1350671 0.01800329 0.3391698 0.01800329 0.21743120 3.6402604 0.02519583 0.006733333 0.05943333 0.05270000 0.6301668002 0.0001774749 FALSE TRUE
MSTRG.1204.9 ENSG00000203995 HEK293_OSMI2_2hA HEK293_TMG_2hB ZYG11A protein_coding   4.775529 2.814977 5.856492 0.2201318 0.1708983 1.054259 0.2847432 0.08109760 0.8469817 0.04055207 0.08332827 3.2337794 0.05224583 0.027700000 0.14406667 0.11636667 0.0001774749 0.0001774749 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203995 E001 0.2987644 0.0274634630 3.882385e-01   1 52842511 52842745 235 + 0.177 0.000 -11.419
ENSG00000203995 E002 0.4460135 0.0357448232 2.039441e-01 3.311245e-01 1 52842746 52842758 13 + 0.244 0.000 -12.002
ENSG00000203995 E003 0.7427016 0.0156907976 6.263986e-02 1.310858e-01 1 52842759 52842759 1 + 0.354 0.000 -12.739
ENSG00000203995 E004 0.8878743 0.0131432302 3.624292e-02 8.404773e-02 1 52842760 52842772 13 + 0.399 0.000 -13.002
ENSG00000203995 E005 1.9563070 0.0072551232 8.344232e-02 1.649501e-01 1 52842773 52842776 4 + 0.576 0.265 -1.716
ENSG00000203995 E006 7.4201082 0.0022321151 4.413795e-01 5.830128e-01 1 52842777 52842872 96 + 0.956 0.864 -0.349
ENSG00000203995 E007 5.5517321 0.0030260947 1.186909e-01 2.180701e-01 1 52842873 52842873 1 + 0.892 0.680 -0.842
ENSG00000203995 E008 17.1150171 0.0011206376 6.463352e-01 7.582704e-01 1 52842874 52842973 100 + 1.270 1.230 -0.138
ENSG00000203995 E009 27.2756983 0.0008732665 5.721626e-01 6.983146e-01 1 52854465 52854630 166 + 1.465 1.426 -0.133
ENSG00000203995 E010 28.3270303 0.0111820349 8.643394e-01 9.165423e-01 1 52856998 52857196 199 + 1.473 1.457 -0.056
ENSG00000203995 E011 65.5717341 0.0013984321 1.201926e-03 4.647155e-03 1 52857197 52857749 553 + 1.875 1.723 -0.513
ENSG00000203995 E012 30.1574318 0.0007014208 1.285282e-01 2.321072e-01 1 52860731 52860871 141 + 1.531 1.433 -0.336
ENSG00000203995 E013 24.3680215 0.0008276730 4.764073e-01 6.150267e-01 1 52863981 52864157 177 + 1.426 1.375 -0.175
ENSG00000203995 E014 20.3876354 0.0015628453 4.825646e-02 1.060891e-01 1 52866503 52866567 65 + 1.387 1.230 -0.548
ENSG00000203995 E015 27.7456601 0.0007504470 4.246018e-01 5.675628e-01 1 52867539 52867638 100 + 1.480 1.426 -0.184
ENSG00000203995 E016 22.5128101 0.0008618107 6.858345e-01 7.884633e-01 1 52867727 52867777 51 + 1.355 1.383 0.099
ENSG00000203995 E017 38.1661224 0.0018610836 7.919763e-01 8.669432e-01 1 52877682 52877843 162 + 1.596 1.580 -0.055
ENSG00000203995 E018 19.1997969 0.0009737946 2.946720e-01 4.357869e-01 1 52877925 52877969 45 + 1.335 1.251 -0.292
ENSG00000203995 E019 7.8047222 0.0021686922 7.029634e-01 8.017097e-01 1 52880601 52880829 229 + 0.957 0.912 -0.169
ENSG00000203995 E020 43.4349425 0.0073795851 6.698708e-01 7.765147e-01 1 52881471 52881665 195 + 1.653 1.626 -0.093
ENSG00000203995 E021 23.4458069 0.0054109813 5.869479e-01 7.103717e-01 1 52885833 52885894 62 + 1.359 1.399 0.138
ENSG00000203995 E022 39.4310710 0.0018807103 6.808618e-01 7.846941e-01 1 52886956 52887053 98 + 1.607 1.581 -0.089
ENSG00000203995 E023 47.5912484 0.0007070998 6.496144e-01 7.608384e-01 1 52892782 52892975 194 + 1.688 1.664 -0.084
ENSG00000203995 E024 80.7145594 0.0004253491 7.513784e-08 7.816935e-07 1 52892976 52893790 815 + 1.817 2.017 0.674
ENSG00000203995 E025 20.5417261 0.0010114723 1.864044e-02 4.854426e-02 1 52893791 52894043 253 + 1.252 1.426 0.608
ENSG00000203995 E026 97.5683455 0.0018202603 3.662676e-04 1.643705e-03 1 52894044 52894998 955 + 1.932 2.066 0.449
ENSG00000203995 E027 14.5837298 0.0072693420 1.839563e-03 6.725196e-03 1 52899514 52899581 68 + 1.293 0.974 -1.144
ENSG00000203995 E028 1.1167064 0.0118960713 6.286229e-01 7.441356e-01 1 52903841 52903928 88 + 0.354 0.265 -0.578
ENSG00000203995 E029 1.2745645 0.2396932564 6.543981e-01 7.645763e-01 1 52907947 52908151 205 + 0.401 0.266 -0.846