ENSG00000203880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308824 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding protein_coding 11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 5.2190575 2.2474115 8.0456104 0.3681524 0.7141454 1.8353244 0.43798750 0.43270000 0.44806667 0.01536667 9.494726e-01 3.12363e-20 FALSE TRUE
ENST00000369758 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding protein_coding 11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 0.2599806 0.3464236 0.3221291 0.2841967 0.1246581 -0.1018487 0.02803750 0.07606667 0.01796667 -0.05810000 8.837221e-01 3.12363e-20 FALSE TRUE
ENST00000609297 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding processed_transcript 11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 1.5337875 0.0000000 3.6398048 0.0000000 0.2608144 8.5116755 0.08903333 0.00000000 0.20283333 0.20283333 3.123630e-20 3.12363e-20   FALSE
ENST00000609818 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding protein_coding 11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 0.4889118 0.6567735 0.3055251 0.6567735 0.1739104 -1.0794421 0.07093750 0.09506667 0.01716667 -0.07790000 9.305764e-01 3.12363e-20 FALSE FALSE
ENST00000610074 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding protein_coding 11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 1.0770763 0.2444960 1.7871630 0.1379257 0.3953661 2.8200063 0.09155417 0.04900000 0.09983333 0.05083333 4.894991e-01 3.12363e-20 FALSE FALSE
MSTRG.21027.10 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding   11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 0.3834738 0.3499685 0.5052492 0.3499685 0.2535730 0.5173998 0.03667917 0.07926667 0.02800000 -0.05126667 8.239400e-01 3.12363e-20 FALSE TRUE
MSTRG.21027.8 ENSG00000203880 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD2 protein_coding   11.72071 5.22227 17.93295 0.8432282 0.1476092 1.777908 1.3269888 0.8967484 1.1493980 0.2008250 0.3884242 0.3546017 0.12073750 0.17090000 0.06423333 -0.10666667 6.288287e-02 3.12363e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203880 E001 0.6234514 0.5965826906 9.024675e-01 9.418887e-01 20 64255695 64255740 46 + 0.197 0.192 -0.043
ENSG00000203880 E002 1.3640767 0.0105929336 2.224423e-01 3.533180e-01 20 64255741 64255746 6 + 0.403 0.191 -1.469
ENSG00000203880 E003 2.3488606 0.4110100011 8.297938e-01 8.931624e-01 20 64255747 64255747 1 + 0.492 0.510 0.091
ENSG00000203880 E004 2.5305650 0.5159706990 8.802142e-01 9.271680e-01 20 64255748 64255748 1 + 0.492 0.580 0.416
ENSG00000203880 E005 2.8335958 0.4409206891 7.655615e-01 8.482870e-01 20 64255749 64255752 4 + 0.543 0.580 0.170
ENSG00000203880 E006 3.2796093 0.4725405626 6.243724e-01 7.406916e-01 20 64255753 64255753 1 + 0.609 0.580 -0.130
ENSG00000203880 E007 3.4247820 0.4265992740 5.786164e-01 7.036799e-01 20 64255754 64255755 2 + 0.629 0.580 -0.217
ENSG00000203880 E008 15.5562364 0.1007683365 4.437407e-01 5.853318e-01 20 64255756 64255843 88 + 1.208 1.117 -0.326
ENSG00000203880 E009 16.1207908 0.0031128957 3.380169e-01 4.818925e-01 20 64255844 64255870 27 + 1.213 1.171 -0.148
ENSG00000203880 E010 4.1760047 0.0037739714 8.338046e-02 1.648595e-01 20 64255871 64255924 54 + 0.748 0.507 -1.055
ENSG00000203880 E011 12.6724159 0.1261354513 8.715036e-02 1.708229e-01 20 64256106 64256196 91 + 1.174 0.850 -1.196
ENSG00000203880 E012 16.2840508 0.0016385248 4.546220e-02 1.010449e-01 20 64256550 64256585 36 + 1.242 1.101 -0.504
ENSG00000203880 E013 38.0876804 0.0005588354 2.954561e-03 1.012871e-02 20 64256586 64256901 316 + 1.594 1.457 -0.470
ENSG00000203880 E014 29.4997191 0.0006538668 8.262614e-05 4.404410e-04 20 64256902 64257051 150 + 1.505 1.259 -0.855
ENSG00000203880 E015 9.3268395 0.0018526047 5.286565e-03 1.671212e-02 20 64258767 64258882 116 + 1.047 0.734 -1.197
ENSG00000203880 E016 6.0078768 0.0032507297 2.396104e-01 3.736549e-01 20 64259831 64259941 111 + 0.853 0.734 -0.470
ENSG00000203880 E017 56.7041843 0.0004433072 2.167840e-02 5.500667e-02 20 64259942 64260084 143 + 1.742 1.676 -0.222
ENSG00000203880 E018 44.9055815 0.0005353185 1.709395e-01 2.894045e-01 20 64260085 64260178 94 + 1.631 1.605 -0.088
ENSG00000203880 E019 51.4989454 0.0040847284 1.396934e-02 3.815417e-02 20 64260179 64260272 94 + 1.710 1.610 -0.341
ENSG00000203880 E020 1.4016525 0.0129948367 7.359504e-01 8.265899e-01 20 64262528 64262687 160 + 0.332 0.425 0.530
ENSG00000203880 E021 0.6277178 0.0382658138 9.525221e-01 9.742759e-01 20 64262771 64262950 180 + 0.197 0.191 -0.054
ENSG00000203880 E022 55.6051604 0.0007558902 1.555511e-02 4.174685e-02 20 64264429 64264531 103 + 1.739 1.666 -0.248
ENSG00000203880 E023 84.0605470 0.0003579326 3.307623e-03 1.116977e-02 20 64265258 64265429 172 + 1.913 1.842 -0.237
ENSG00000203880 E024 1.5510666 0.0248457645 1.748886e-01 2.945339e-01 20 64265512 64265613 102 + 0.435 0.192 -1.636
ENSG00000203880 E025 56.9922037 0.0004004677 3.463469e-03 1.162098e-02 20 64267887 64267967 81 + 1.754 1.656 -0.333
ENSG00000203880 E026 46.9221757 0.0004597749 6.064018e-03 1.877877e-02 20 64267968 64268010 43 + 1.672 1.568 -0.354
ENSG00000203880 E027 2.6614553 0.0057998716 9.082277e-01 9.457120e-01 20 64271482 64272230 749 + 0.518 0.576 0.268
ENSG00000203880 E028 643.7822357 0.0020926715 7.605874e-17 3.322366e-15 20 64273221 64276226 3006 + 2.716 2.884 0.559
ENSG00000203880 E029 0.1451727 0.0444047638 1.000000e+00   20 64287679 64287821 143 + 0.076 0.001 -6.999