ENSG00000203879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447750 ENSG00000203879 HEK293_OSMI2_2hA HEK293_TMG_2hB GDI1 protein_coding protein_coding 152.6851 258.4567 87.95491 8.415733 0.9911136 -1.554978 126.066287 234.499509 67.901436 6.5887194 0.6498466 -1.7879200 0.79335000 0.90760000 0.7721333 -0.13546667 2.007463e-17 2.007463e-17 FALSE TRUE
ENST00000489589 ENSG00000203879 HEK293_OSMI2_2hA HEK293_TMG_2hB GDI1 protein_coding retained_intron 152.6851 258.4567 87.95491 8.415733 0.9911136 -1.554978 8.167593 6.936481 5.108543 0.5567836 0.3923289 -0.4405493 0.06210833 0.02676667 0.0581000 0.03133333 1.459939e-06 2.007463e-17 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203879 E001 3.208607 6.176913e-03 9.925498e-06 6.602605e-05 X 154436913 154436972 60 + 0.963 0.319 -2.915
ENSG00000203879 E002 41.041633 1.735404e-02 1.781640e-06 1.401048e-05 X 154436973 154437153 181 + 1.795 1.417 -1.288
ENSG00000203879 E003 32.899428 4.586189e-03 4.698015e-04 2.044624e-03 X 154437154 154437163 10 + 1.604 1.372 -0.797
ENSG00000203879 E004 32.764763 4.715990e-03 1.883002e-03 6.862155e-03 X 154437164 154437165 2 + 1.585 1.379 -0.709
ENSG00000203879 E005 164.624954 1.361766e-02 8.768868e-04 3.533191e-03 X 154437166 154437188 23 + 2.261 2.079 -0.609
ENSG00000203879 E006 745.280936 1.082486e-03 7.766684e-01 8.561723e-01 X 154437189 154437299 111 + 2.750 2.783 0.109
ENSG00000203879 E007 4.288792 3.909353e-03 2.855748e-05 1.707258e-04 X 154437660 154437942 283 + 1.016 0.449 -2.370
ENSG00000203879 E008 6.512628 1.396480e-02 2.455682e-08 2.813047e-07 X 154438006 154438215 210 + 1.225 0.527 -2.743
ENSG00000203879 E009 6.785002 2.500778e-03 2.166090e-09 3.015795e-08 X 154438216 154438386 171 + 1.240 0.548 -2.692
ENSG00000203879 E010 4.237398 4.333362e-03 4.865436e-06 3.474340e-05 X 154438387 154438475 89 + 1.039 0.420 -2.610
ENSG00000203879 E011 4.897393 3.366867e-03 7.488199e-05 4.036584e-04 X 154438476 154438522 47 + 1.039 0.525 -2.080
ENSG00000203879 E012 1060.705519 1.371651e-03 1.560654e-01 2.698796e-01 X 154438523 154438630 108 + 2.884 2.942 0.192
ENSG00000203879 E013 1225.452298 7.362385e-04 5.763908e-01 7.018292e-01 X 154438765 154438864 100 + 2.980 2.997 0.054
ENSG00000203879 E014 1521.146852 9.596760e-05 2.676100e-06 2.025648e-05 X 154439006 154439140 135 + 3.109 3.080 -0.094
ENSG00000203879 E015 7.008448 4.289097e-03 2.242380e-07 2.129064e-06 X 154439141 154439251 111 + 1.210 0.611 -2.305
ENSG00000203879 E016 7.574727 2.768937e-03 1.131462e-06 9.288153e-06 X 154439710 154439797 88 + 1.210 0.665 -2.071
ENSG00000203879 E017 1088.582978 8.022705e-05 1.111419e-04 5.730322e-04 X 154439941 154439992 52 + 2.962 2.936 -0.086
ENSG00000203879 E018 1583.665431 1.401731e-04 5.999823e-02 1.265981e-01 X 154439993 154440139 147 + 3.102 3.105 0.011
ENSG00000203879 E019 53.419638 4.761029e-04 8.723398e-09 1.087251e-07 X 154440140 154440267 128 + 1.845 1.568 -0.939
ENSG00000203879 E020 70.890658 5.935498e-04 1.548965e-12 3.677277e-11 X 154440268 154440374 107 + 1.979 1.677 -1.017
ENSG00000203879 E021 1524.823726 2.529582e-04 5.166598e-02 1.121217e-01 X 154440375 154440506 132 + 3.087 3.087 0.002
ENSG00000203879 E022 14.562117 1.342481e-03 2.575033e-07 2.415131e-06 X 154440507 154440523 17 + 1.408 0.961 -1.593
ENSG00000203879 E023 25.387639 1.047810e-02 5.245436e-14 1.552221e-12 X 154440524 154440650 127 + 1.720 1.115 -2.097
ENSG00000203879 E024 59.438756 6.377454e-03 2.133948e-27 2.865132e-25 X 154440651 154441095 445 + 2.087 1.465 -2.105
ENSG00000203879 E025 1323.160417 5.846276e-04 1.272416e-01 2.302937e-01 X 154441096 154441195 100 + 2.985 3.036 0.169
ENSG00000203879 E026 41.781514 6.386116e-03 1.828223e-14 5.795706e-13 X 154441196 154441622 427 + 1.870 1.384 -1.654
ENSG00000203879 E027 1587.876628 5.665856e-04 6.593727e-02 1.365936e-01 X 154441623 154441765 143 + 3.061 3.116 0.181
ENSG00000203879 E028 1077.554079 8.664787e-05 3.046634e-01 4.466889e-01 X 154441766 154441794 29 + 2.905 2.944 0.129
ENSG00000203879 E029 40.577878 5.082166e-04 6.866819e-27 8.760257e-25 X 154441795 154442048 254 + 1.906 1.331 -1.960
ENSG00000203879 E030 26.020081 7.143083e-03 3.837211e-13 1.004905e-11 X 154442049 154442110 62 + 1.705 1.159 -1.888
ENSG00000203879 E031 1782.140302 6.873707e-05 3.042294e-01 4.462391e-01 X 154442111 154442255 145 + 3.126 3.162 0.119
ENSG00000203879 E032 17.738804 1.321407e-03 3.662383e-05 2.130331e-04 X 154442256 154442373 118 + 1.427 1.099 -1.154
ENSG00000203879 E033 1208.786895 1.057617e-04 9.666945e-01 9.831142e-01 X 154442374 154442428 55 + 2.967 2.992 0.081
ENSG00000203879 E034 30.167702 9.483944e-04 2.595874e-06 1.970827e-05 X 154442429 154442519 91 + 1.623 1.328 -1.016
ENSG00000203879 E035 4614.339347 2.744642e-03 2.167114e-06 1.672451e-05 X 154442520 154443467 948 + 3.463 3.594 0.435