ENSG00000203867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369519 ENSG00000203867 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM20 protein_coding protein_coding 3.769526 3.8129 2.374005 0.1135116 0.05432332 -0.6812802 1.7006215 1.273877 1.78155389 0.2353838 0.17292549 0.4807046 0.4924333 0.3385000 0.7487333 0.4102333 0.0046477786 0.0001011199 FALSE TRUE
ENST00000480343 ENSG00000203867 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM20 protein_coding processed_transcript 3.769526 3.8129 2.374005 0.1135116 0.05432332 -0.6812802 1.1222393 2.031438 0.05345244 0.2753547 0.05345244 -5.0077665 0.2516750 0.5315333 0.0220000 -0.5095333 0.0001011199 0.0001011199 FALSE TRUE
MSTRG.4632.2 ENSG00000203867 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM20 protein_coding   3.769526 3.8129 2.374005 0.1135116 0.05432332 -0.6812802 0.7872292 0.422631 0.51892741 0.2944903 0.14110033 0.2899326 0.2192708 0.1083333 0.2210000 0.1126667 0.5396056494 0.0001011199 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203867 E001 4.9058279 0.0037362122 1.654611e-02 4.394150e-02 10 110644336 110644569 234 + 0.897 0.658 -0.954
ENSG00000203867 E002 2.7366982 0.0055568946 4.193821e-03 1.368830e-02 10 110644570 110644645 76 + 0.747 0.360 -1.828
ENSG00000203867 E003 43.4059615 0.0006754796 9.910967e-06 6.593865e-05 10 110780801 110781884 1084 + 1.711 1.575 -0.465
ENSG00000203867 E004 10.7887987 0.0016300781 5.953454e-03 1.848508e-02 10 110783366 110783427 62 + 1.159 0.973 -0.677
ENSG00000203867 E005 0.8909948 0.0135966166 5.080759e-02 1.106145e-01 10 110784311 110784340 30 + 0.421 0.122 -2.343
ENSG00000203867 E006 12.2743126 0.0219383224 1.072143e-02 3.050223e-02 10 110784341 110784432 92 + 1.215 1.006 -0.755
ENSG00000203867 E007 16.7176517 0.0251418986 2.320904e-02 5.818061e-02 10 110784792 110784889 98 + 1.323 1.158 -0.580
ENSG00000203867 E008 19.4770360 0.0011260827 1.169353e-03 4.537049e-03 10 110797508 110797648 141 + 1.385 1.226 -0.554
ENSG00000203867 E009 15.5536791 0.0012213441 8.012850e-04 3.264184e-03 10 110799787 110799918 132 + 1.308 1.113 -0.692
ENSG00000203867 E010 14.6939557 0.0013196437 3.357929e-02 7.892772e-02 10 110810383 110810462 80 + 1.240 1.144 -0.341
ENSG00000203867 E011 48.0813947 0.0021469323 1.247953e-06 1.015598e-05 10 110812278 110812947 670 + 1.763 1.601 -0.551
ENSG00000203867 E012 20.8158835 0.0010524573 8.412493e-02 1.660109e-01 10 110820072 110820176 105 + 1.355 1.316 -0.133
ENSG00000203867 E013 59.3868312 0.0004997010 2.113767e-01 3.401111e-01 10 110821275 110821935 661 + 1.756 1.793 0.125
ENSG00000203867 E014 21.0225270 0.0010218846 7.550686e-01 8.405203e-01 10 110823480 110823587 108 + 1.301 1.368 0.231
ENSG00000203867 E015 11.2351017 0.0032626028 1.274066e-01 2.305373e-01 10 110823588 110823614 27 + 0.931 1.174 0.884
ENSG00000203867 E016 1.0393871 0.0142081343 7.843779e-01 8.616874e-01 10 110827771 110827854 84 + 0.297 0.295 -0.018
ENSG00000203867 E017 21.4625880 0.0097005193 1.299609e-02 3.590227e-02 10 110831061 110831182 122 + 1.149 1.461 1.090
ENSG00000203867 E018 0.4815130 0.0204553314 7.076519e-01 8.055142e-01 10 110831183 110831513 331 + 0.123 0.216 0.979
ENSG00000203867 E019 0.8512514 0.0136968632 2.591902e-01 3.965673e-01 10 110835178 110835691 514 + 0.123 0.360 1.980
ENSG00000203867 E020 319.2704923 0.0104769234 3.827475e-08 4.222101e-07 10 110835868 110839468 3601 + 2.340 2.603 0.874