ENSG00000203499

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000532625 ENSG00000203499 HEK293_OSMI2_2hA HEK293_TMG_2hB IQANK1 protein_coding retained_intron 2.324963 3.554227 1.876245 0.2702937 0.1987483 -0.9180718 0.08833695 0.1913272 0.0000000 0.05552537 0.00000000 -4.3314704 0.0303625 0.0530000 0.0000000 -0.0530000 0.005990865 0.005990865 FALSE  
ENST00000533004 ENSG00000203499 HEK293_OSMI2_2hA HEK293_TMG_2hB IQANK1 protein_coding protein_coding 2.324963 3.554227 1.876245 0.2702937 0.1987483 -0.9180718 1.52832824 2.7089833 1.2371396 0.18864140 0.02899851 -1.1244444 0.6170792 0.7631333 0.6728333 -0.0903000 0.512255992 0.005990865 FALSE  
ENST00000534398 ENSG00000203499 HEK293_OSMI2_2hA HEK293_TMG_2hB IQANK1 protein_coding processed_transcript 2.324963 3.554227 1.876245 0.2702937 0.1987483 -0.9180718 0.64207320 0.5222848 0.6255864 0.11131366 0.20420201 0.2558898 0.3104292 0.1464000 0.3187333 0.1723333 0.163555773 0.005990865 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203499 E001 2.6508316 0.006414436 0.0139210793 0.0380470405 8 143734139 143734139 1 + 0.681 0.427 -1.182
ENSG00000203499 E002 6.7929522 0.040852632 0.0047246165 0.0151622217 8 143734140 143734219 80 + 1.005 0.764 -0.922
ENSG00000203499 E003 6.6758921 0.069668556 0.0299303683 0.0718249222 8 143735850 143735938 89 + 0.970 0.787 -0.702
ENSG00000203499 E004 0.7300267 0.024823079 0.7620402695 0.8457450918 8 143739396 143739503 108 + 0.140 0.264 1.142
ENSG00000203499 E005 4.8430911 0.043669052 0.0136780877 0.0374905623 8 143739859 143739948 90 + 0.872 0.643 -0.927
ENSG00000203499 E006 13.4118501 0.001755922 0.0001117656 0.0005759189 8 143741752 143742135 384 + 1.239 1.075 -0.587
ENSG00000203499 E007 143.3396991 0.039077136 0.0013243724 0.0050577214 8 143743860 143746337 2478 + 1.943 2.234 0.977
ENSG00000203499 E008 0.5838113 0.374627155 0.2134293438 0.3425728965 8 143771488 143771618 131 + 0.329 0.105 -2.053
ENSG00000203499 E009 0.0000000       8 143771801 143771965 165 +      
ENSG00000203499 E010 0.0000000       8 143772052 143772243 192 +      
ENSG00000203499 E011 0.4782907 0.023320363 0.2743073364 0.4134414959 8 143772357 143772482 126 + 0.000 0.263 16.642
ENSG00000203499 E012 0.5514428 0.019747051 0.2723799073 0.4112580560 8 143788915 143788919 5 + 0.000 0.264 16.650
ENSG00000203499 E013 1.1018414 0.012198908 0.3926147344 0.5365609141 8 143788920 143789063 144 + 0.140 0.379 1.877
ENSG00000203499 E014 0.1482932 0.042319992 1.0000000000   8 143789189 143789243 55 + 0.000 0.107 15.190
ENSG00000203499 E015 0.1482932 0.042319992 1.0000000000   8 143789404 143789435 32 + 0.000 0.107 15.190
ENSG00000203499 E016 0.1482932 0.042319992 1.0000000000   8 143789436 143789514 79 + 0.000 0.107 15.190
ENSG00000203499 E017 0.0000000       8 143789515 143789528 14 +      
ENSG00000203499 E018 0.5848540 0.030791075 0.2743861644 0.4135299594 8 143789761 143789869 109 + 0.000 0.265 16.637
ENSG00000203499 E019 0.3634088 0.389909608 0.6050108493   8 143789870 143789970 101 + 0.000 0.194 15.768
ENSG00000203499 E020 0.3634088 0.389909608 0.6050108493   8 143789971 143790064 94 + 0.000 0.194 15.768
ENSG00000203499 E021 0.9148515 0.015983421 0.0984668026 0.1881662785 8 143790065 143790136 72 + 0.000 0.379 17.281
ENSG00000203499 E022 0.9148515 0.015983421 0.0984668026 0.1881662785 8 143790137 143790271 135 + 0.000 0.379 17.281
ENSG00000203499 E023 0.1817044 0.039999309 1.0000000000   8 143790272 143790275 4 + 0.000 0.107 15.196
ENSG00000203499 E024 0.1817044 0.039999309 1.0000000000   8 143790350 143790645 296 + 0.000 0.107 15.196