ENSG00000203485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330634 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding protein_coding 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 2.968199 4.5020740 2.514592 0.3314800 0.09407275 -0.8377406 0.09783750 0.10496667 0.10296667 -0.00200000 9.891761e-01 5.68821e-12 FALSE TRUE
ENST00000398337 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding protein_coding 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 8.193311 14.2972575 3.948067 0.8613144 0.31090014 -1.8538793 0.25507083 0.33126667 0.16236667 -0.16890000 7.597844e-07 5.68821e-12 FALSE TRUE
ENST00000674631 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding protein_coding 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 4.010338 7.2693990 2.024367 0.1436586 0.32877225 -1.8392394 0.12255417 0.17033333 0.08193333 -0.08840000 1.464674e-03 5.68821e-12 FALSE TRUE
ENST00000675557 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding retained_intron 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 2.041909 0.9237352 3.006386 0.2313344 0.33128080 1.6917355 0.07923750 0.02096667 0.12216667 0.10120000 5.688210e-12 5.68821e-12 FALSE FALSE
ENST00000675771 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding nonsense_mediated_decay 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 2.825957 2.6044584 3.078864 1.3145686 0.49920495 0.2405641 0.10299583 0.06416667 0.12653333 0.06236667 6.809790e-01 5.68821e-12 FALSE TRUE
ENST00000675797 ENSG00000203485 HEK293_OSMI2_2hA HEK293_TMG_2hB INF2 protein_coding nonsense_mediated_decay 29.93599 43.26046 24.49989 3.058154 1.548433 -0.8200187 2.825336 5.3617322 2.349064 1.9749837 1.23796113 -1.1871727 0.09348333 0.11893333 0.09276667 -0.02616667 8.430750e-01 5.68821e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000203485 E001 0.0000000       14 104681146 104681582 437 +      
ENSG00000203485 E002 0.0000000       14 104684063 104684932 870 +      
ENSG00000203485 E003 0.0000000       14 104688307 104688572 266 +      
ENSG00000203485 E004 0.6955713 0.0162153247 4.893492e-01 6.267974e-01 14 104689152 104689245 94 + 0.281 0.166 -0.965
ENSG00000203485 E005 0.1472490 0.0426752432 2.430605e-01   14 104689523 104689600 78 + 0.163 0.000 -13.259
ENSG00000203485 E006 1.2449403 0.0138998506 1.704541e-02 4.503581e-02 14 104689601 104689605 5 + 0.572 0.166 -2.551
ENSG00000203485 E007 1.3932335 0.0097724529 4.223096e-02 9.514359e-02 14 104689606 104689608 3 + 0.572 0.230 -1.967
ENSG00000203485 E008 5.2318592 0.0034485043 2.719800e-03 9.432118e-03 14 104689609 104689617 9 + 0.984 0.605 -1.513
ENSG00000203485 E009 8.7524898 0.0029253272 3.815275e-03 1.262365e-02 14 104689618 104689620 3 + 1.138 0.834 -1.129
ENSG00000203485 E010 8.7524898 0.0029253272 3.815275e-03 1.262365e-02 14 104689621 104689622 2 + 1.138 0.834 -1.129
ENSG00000203485 E011 82.9047016 0.0140075747 1.103651e-01 2.060706e-01 14 104689623 104689739 117 + 1.939 1.855 -0.285
ENSG00000203485 E012 11.7362755 0.0015378617 1.740739e-02 4.583938e-02 14 104695990 104696490 501 + 0.840 1.125 1.062
ENSG00000203485 E013 0.1817044 0.0399741433 1.000000e+00   14 104699368 104699598 231 + 0.000 0.091 11.052
ENSG00000203485 E014 0.2214452 0.0377650051 1.000000e+00   14 104699599 104699803 205 + 0.000 0.091 11.055
ENSG00000203485 E015 0.2214452 0.0377650051 1.000000e+00   14 104699804 104699826 23 + 0.000 0.091 11.055
ENSG00000203485 E016 0.2214452 0.0377650051 1.000000e+00   14 104699827 104699834 8 + 0.000 0.091 11.055
ENSG00000203485 E017 0.0000000       14 104700678 104700709 32 +      
ENSG00000203485 E018 0.4031496 0.0244643140 4.678856e-01 6.073280e-01 14 104700737 104700864 128 + 0.000 0.166 12.054
ENSG00000203485 E019 60.4278429 0.0216850801 1.089556e-01 2.039917e-01 14 104701357 104701365 9 + 1.817 1.711 -0.357
ENSG00000203485 E020 277.8902153 0.0062713473 1.150433e-01 2.128982e-01 14 104701366 104701756 391 + 2.435 2.391 -0.147
ENSG00000203485 E021 8.3231440 0.0020657386 1.297706e-01 2.338421e-01 14 104702512 104703104 593 + 0.778 0.983 0.784
ENSG00000203485 E022 191.7838557 0.0007214973 6.390818e-02 1.332058e-01 14 104703105 104703220 116 + 2.267 2.229 -0.126
ENSG00000203485 E023 110.7757236 0.0002642058 1.388226e-02 3.795957e-02 14 104703295 104703305 11 + 2.053 1.981 -0.239
ENSG00000203485 E024 227.9199903 0.0002635208 8.099584e-01 8.793867e-01 14 104703306 104703454 149 + 2.299 2.322 0.076
ENSG00000203485 E025 110.1529794 0.0021183531 3.541394e-01 4.984117e-01 14 104703916 104703949 34 + 1.964 2.020 0.189
ENSG00000203485 E026 270.8114649 0.0036793296 5.597617e-28 7.919730e-26 14 104703950 104704809 860 + 2.020 2.490 1.569
ENSG00000203485 E027 116.9074737 0.0018350329 6.995769e-03 2.121237e-02 14 104706035 104706152 118 + 2.088 1.999 -0.298
ENSG00000203485 E028 55.0156190 0.0055341141 4.118379e-01 5.553840e-01 14 104706153 104706176 24 + 1.723 1.692 -0.104
ENSG00000203485 E029 2.0543600 0.0081429498 5.390843e-01 6.703945e-01 14 104706600 104706697 98 + 0.515 0.420 -0.480
ENSG00000203485 E030 108.1650413 0.0021153232 2.661934e-04 1.241957e-03 14 104706910 104707051 142 + 2.082 1.950 -0.442
ENSG00000203485 E031 134.7167143 0.0079016016 2.513434e-04 1.180822e-03 14 104707253 104707847 595 + 2.204 2.032 -0.576
ENSG00000203485 E032 32.2908680 0.0088696146 3.408175e-01 4.847471e-01 14 104707848 104707863 16 + 1.517 1.461 -0.192
ENSG00000203485 E033 104.0808823 0.0003067068 1.133028e-03 4.414650e-03 14 104707864 104708002 139 + 2.047 1.945 -0.344
ENSG00000203485 E034 0.7363694 0.0316010912 7.371174e-01 8.273769e-01 14 104708291 104708435 145 + 0.163 0.231 0.622
ENSG00000203485 E035 127.1166574 0.0002377822 4.828711e-04 2.094645e-03 14 104708436 104708531 96 + 2.131 2.032 -0.331
ENSG00000203485 E036 116.5023217 0.0002423250 5.545487e-03 1.740632e-02 14 104708532 104708587 56 + 2.082 2.002 -0.267
ENSG00000203485 E037 9.4972688 0.0019733383 2.932999e-05 1.749521e-04 14 104708588 104708670 83 + 1.228 0.803 -1.571
ENSG00000203485 E038 130.8388652 0.0002475556 2.339736e-02 5.857207e-02 14 104708671 104708732 62 + 2.118 2.059 -0.195
ENSG00000203485 E039 92.9279006 0.0003204181 1.724186e-01 2.913557e-01 14 104709281 104709293 13 + 1.955 1.918 -0.125
ENSG00000203485 E040 163.4263224 0.0008306751 8.437692e-02 1.664146e-01 14 104709294 104709383 90 + 2.198 2.160 -0.128
ENSG00000203485 E041 142.6254488 0.0002644820 3.656179e-01 5.099379e-01 14 104709620 104709705 86 + 2.124 2.111 -0.042
ENSG00000203485 E042 120.8270852 0.0002976509 7.443069e-01 8.326938e-01 14 104710088 104710188 101 + 2.022 2.050 0.093
ENSG00000203485 E043 3.7346810 0.1730729423 1.392341e-02 3.805231e-02 14 104710725 104710881 157 + 0.961 0.381 -2.533
ENSG00000203485 E044 2.1787964 0.0066007370 3.804074e-03 1.259297e-02 14 104710882 104710918 37 + 0.744 0.286 -2.289
ENSG00000203485 E045 2.8399123 0.0055285263 8.226025e-04 3.340255e-03 14 104710919 104710936 18 + 0.840 0.335 -2.345
ENSG00000203485 E046 97.9123682 0.0002906752 3.028059e-02 7.251746e-02 14 104710937 104710989 53 + 1.997 1.931 -0.221
ENSG00000203485 E047 81.6369380 0.0003428201 1.076068e-02 3.059183e-02 14 104710990 104711007 18 + 1.935 1.846 -0.299
ENSG00000203485 E048 4.6228443 0.0255544323 7.058909e-04 2.919909e-03 14 104711008 104711011 4 + 1.004 0.520 -1.976
ENSG00000203485 E049 10.2544934 0.0431249401 1.541684e-04 7.656769e-04 14 104711012 104711078 67 + 1.303 0.801 -1.841
ENSG00000203485 E050 70.2244431 0.0003636684 8.251167e-04 3.348956e-03 14 104711079 104711083 5 + 1.899 1.769 -0.438
ENSG00000203485 E051 147.1066079 0.0002341464 3.014742e-04 1.385575e-03 14 104711084 104711186 103 + 2.191 2.096 -0.318
ENSG00000203485 E052 134.9543542 0.0002726430 4.176920e-02 9.430361e-02 14 104711629 104711699 71 + 2.125 2.075 -0.168
ENSG00000203485 E053 196.1535320 0.0002414688 7.487581e-02 1.513292e-01 14 104712433 104712553 121 + 2.275 2.243 -0.107
ENSG00000203485 E054 1.1844606 0.0105805411 1.639645e-02 4.360702e-02 14 104712713 104712827 115 + 0.572 0.166 -2.553
ENSG00000203485 E055 104.2857526 0.0018448430 5.734085e-01 6.993351e-01 14 104712828 104712832 5 + 1.987 1.981 -0.021
ENSG00000203485 E056 255.3277985 0.0002198438 1.391118e-03 5.277617e-03 14 104712833 104712992 160 + 2.408 2.348 -0.199
ENSG00000203485 E057 4.6123725 0.0034555990 1.585593e-02 4.241539e-02 14 104713202 104713206 5 + 0.918 0.605 -1.267
ENSG00000203485 E058 200.6462420 0.0001950059 3.824325e-01 5.266460e-01 14 104713207 104713304 98 + 2.267 2.260 -0.024
ENSG00000203485 E059 83.5428653 0.0005234331 1.802234e-02 4.718071e-02 14 104713305 104713309 5 + 1.795 1.915 0.405
ENSG00000203485 E060 82.0967451 0.0005018802 4.212010e-02 9.494350e-02 14 104713445 104713448 4 + 1.798 1.904 0.357
ENSG00000203485 E061 220.4271984 0.0006124394 1.050988e-03 4.136076e-03 14 104713449 104713606 158 + 2.223 2.333 0.369
ENSG00000203485 E062 1.9907478 0.0521286943 3.200068e-02 7.586102e-02 14 104713821 104713933 113 + 0.667 0.288 -1.955
ENSG00000203485 E063 170.2456136 0.0039282106 1.045808e-02 2.988180e-02 14 104714203 104714283 81 + 2.101 2.227 0.422
ENSG00000203485 E064 198.2913084 0.0037351858 9.812979e-03 2.830105e-02 14 104714284 104714395 112 + 2.170 2.293 0.409
ENSG00000203485 E065 198.2146010 0.0002039845 4.158498e-04 1.835244e-03 14 104714396 104714507 112 + 2.170 2.287 0.389
ENSG00000203485 E066 215.6760668 0.0019428471 5.847996e-03 1.821311e-02 14 104714508 104714588 81 + 2.210 2.323 0.378
ENSG00000203485 E067 355.2736240 0.0070462092 8.992499e-02 1.750228e-01 14 104714589 104714856 268 + 2.439 2.539 0.332
ENSG00000203485 E068 40.2570271 0.0066242006 1.209416e-01 2.212931e-01 14 104714857 104715280 424 + 1.485 1.614 0.441
ENSG00000203485 E069 4.0973822 0.1567485028 7.174432e-01 8.128159e-01 14 104715281 104715283 3 + 0.623 0.706 0.355
ENSG00000203485 E070 41.9387764 0.0017738251 2.062034e-12 4.806770e-11 14 104715284 104715340 57 + 1.152 1.692 1.871
ENSG00000203485 E071 5.8076182 0.0029238909 4.990121e-05 2.812996e-04 14 104715725 104715832 108 + 1.076 0.579 -1.966
ENSG00000203485 E072 8.9912577 0.0024563038 2.848442e-06 2.142745e-05 14 104715833 104716017 185 + 1.240 0.753 -1.814
ENSG00000203485 E073 4.6771927 0.0035457869 1.007638e-02 2.894790e-02 14 104717548 104717562 15 + 0.918 0.579 -1.380
ENSG00000203485 E074 9.6257630 0.0018331682 1.808565e-02 4.731309e-02 14 104717563 104717646 84 + 1.138 0.902 -0.867
ENSG00000203485 E075 557.7056542 0.0069342537 1.005779e-03 3.978490e-03 14 104718795 104722535 3741 + 2.589 2.750 0.537