ENSG00000198960

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361910 ENSG00000198960 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMCX6 protein_coding protein_coding 37.62104 72.46998 20.67267 3.989287 0.1318163 -1.80916 9.531529 13.3575141 5.365557 1.50600769 0.2193881 -1.314245 0.28479583 0.183066667 0.25943333 0.07636667 2.206302e-02 1.916956e-12 FALSE  
ENST00000494624 ENSG00000198960 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMCX6 protein_coding processed_transcript 37.62104 72.46998 20.67267 3.989287 0.1318163 -1.80916 1.235326 0.6315032 1.374366 0.09354355 0.1889550 1.109697 0.04485417 0.008666667 0.06636667 0.05770000 1.916956e-12 1.916956e-12    
ENST00000497931 ENSG00000198960 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMCX6 protein_coding processed_transcript 37.62104 72.46998 20.67267 3.989287 0.1318163 -1.80916 22.916561 49.2707627 12.355419 1.76730633 0.1442478 -1.994713 0.57310000 0.681633333 0.59776667 -0.08386667 7.454088e-02 1.916956e-12    
MSTRG.34601.5 ENSG00000198960 HEK293_OSMI2_2hA HEK293_TMG_2hB ARMCX6 protein_coding   37.62104 72.46998 20.67267 3.989287 0.1318163 -1.80916 2.781504 6.8284618 1.145689 1.36111837 0.2491827 -2.564919 0.06609583 0.092900000 0.05556667 -0.03733333 3.031184e-01 1.916956e-12    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198960 E001 0.0000000       X 101615118 101615124 7 -      
ENSG00000198960 E002 0.0000000       X 101615125 101615125 1 -      
ENSG00000198960 E003 0.3299976 0.0274424043 8.400253e-01   X 101615126 101615166 41 - 0.001 0.131 7.844
ENSG00000198960 E004 28.6484268 0.0067490987 1.291736e-04 6.552305e-04 X 101615167 101615467 301 - 1.050 1.435 1.359
ENSG00000198960 E005 15.5447827 0.0035530894 5.278975e-01 6.608444e-01 X 101615468 101615512 45 - 1.073 1.136 0.227
ENSG00000198960 E006 159.9649438 0.0012683354 1.128826e-03 4.400623e-03 X 101615513 101615760 248 - 2.011 2.127 0.389
ENSG00000198960 E007 42.9711306 0.0005781532 8.114731e-02 1.613311e-01 X 101615761 101616212 452 - 1.635 1.526 -0.372
ENSG00000198960 E008 87.4866612 0.0046225493 4.250774e-01 5.680222e-01 X 101616213 101616395 183 - 1.889 1.841 -0.159
ENSG00000198960 E009 124.7155830 0.0023977522 6.103108e-03 1.888100e-02 X 101616396 101616671 276 - 2.094 1.981 -0.381
ENSG00000198960 E010 337.9735272 0.0001721014 3.479004e-02 8.124338e-02 X 101616672 101616766 95 - 2.399 2.440 0.136
ENSG00000198960 E011 20.7611723 0.0085482063 3.572497e-13 9.394765e-12 X 101616862 101617282 421 - 1.658 1.041 -2.155
ENSG00000198960 E012 9.7141754 0.0018420392 7.267550e-02 1.477968e-01 X 101617283 101617291 9 - 1.095 0.886 -0.773
ENSG00000198960 E013 17.3093335 0.0012489925 8.881602e-03 2.598439e-02 X 101617292 101617370 79 - 1.344 1.107 -0.836
ENSG00000198960 E014 6.7376865 0.0030843704 8.920467e-10 1.334562e-08 X 101617371 101617502 132 - 1.266 0.540 -2.824
ENSG00000198960 E015 274.5283295 0.0002258350 2.724569e-01 4.113464e-01 X 101617503 101617584 82 - 2.324 2.347 0.075
ENSG00000198960 E016 200.9844198 0.0003166398 1.482011e-01 2.592356e-01 X 101617885 101618006 122 - 2.177 2.215 0.129