ENSG00000198954

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361983 ENSG00000198954 HEK293_OSMI2_2hA HEK293_TMG_2hB KIFBP protein_coding protein_coding 21.92026 16.18749 30.02449 1.188886 0.9107012 0.8908495 18.328033 10.964849 25.5252668 0.2450987 0.5282293 1.21829 0.8186167 0.6866000 0.85133333 0.1647333 0.09656021 5.77633e-08 FALSE TRUE
ENST00000674897 ENSG00000198954 HEK293_OSMI2_2hA HEK293_TMG_2hB KIFBP protein_coding protein_coding 21.92026 16.18749 30.02449 1.188886 0.9107012 0.8908495 1.362986 3.657832 0.5073735 1.5119451 0.4420244 -2.82565 0.0817875 0.2149667 0.01676667 -0.1982000 0.03912527 5.77633e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198954 E001 182.0276914 0.0115351735 1.831066e-03 6.698400e-03 10 68988803 68989212 410 + 2.298 2.159 -0.466
ENSG00000198954 E002 64.0168458 0.0041734249 4.661514e-02 1.031441e-01 10 68989213 68989258 46 + 1.827 1.757 -0.234
ENSG00000198954 E003 3.1407611 0.0608479790 6.095861e-02 1.282474e-01 10 68989481 68989629 149 + 0.421 0.781 1.622
ENSG00000198954 E004 2.0940121 0.0674419228 1.415282e-02 3.857188e-02 10 68989717 68989742 26 + 0.231 0.707 2.547
ENSG00000198954 E005 2.5628528 0.1954607135 5.617564e-02 1.200107e-01 10 68989743 68989859 117 + 0.287 0.779 2.421
ENSG00000198954 E006 1.9426912 0.0345621589 2.372426e-02 5.924249e-02 10 68995204 68995278 75 + 0.580 0.162 -2.628
ENSG00000198954 E007 0.6632174 0.0321854102 1.225038e-01 2.235169e-01 10 68999715 68999814 100 + 0.091 0.373 2.538
ENSG00000198954 E008 89.4837420 0.0003335458 6.762098e-05 3.686501e-04 10 69000424 69000522 99 + 1.985 1.872 -0.381
ENSG00000198954 E009 77.9913547 0.0003923417 4.656081e-02 1.030492e-01 10 69005046 69005096 51 + 1.901 1.861 -0.134
ENSG00000198954 E010 81.1959468 0.0012383443 5.052394e-02 1.100919e-01 10 69005097 69005125 29 + 1.918 1.877 -0.139
ENSG00000198954 E011 173.2363570 0.0002666067 1.749088e-01 2.945601e-01 10 69005732 69005915 184 + 2.227 2.233 0.018
ENSG00000198954 E012 13.9897506 0.0012657975 8.218969e-15 2.736964e-13 10 69005916 69006841 926 + 1.348 0.373 -3.968
ENSG00000198954 E013 5.0515603 0.0367724755 1.891804e-04 9.177421e-04 10 69006842 69006929 88 + 0.929 0.279 -3.053
ENSG00000198954 E014 15.1032202 0.0015191568 1.245433e-11 2.553224e-10 10 69006930 69007626 697 + 1.357 0.620 -2.777
ENSG00000198954 E015 2.6069381 0.0073889335 9.142874e-01 9.497253e-01 10 69007627 69007654 28 + 0.523 0.571 0.219
ENSG00000198954 E016 5.2047838 0.0030954556 5.604331e-03 1.756454e-02 10 69007655 69007751 97 + 0.891 0.514 -1.581
ENSG00000198954 E017 9.3131469 0.0027116489 2.147760e-03 7.683340e-03 10 69008421 69008840 420 + 1.103 0.777 -1.230
ENSG00000198954 E018 177.1943797 0.0002352502 4.037526e-01 5.475284e-01 10 69008841 69008925 85 + 2.232 2.252 0.068
ENSG00000198954 E019 210.0048918 0.0001784109 7.331088e-01 8.243965e-01 10 69010900 69011015 116 + 2.300 2.335 0.115
ENSG00000198954 E020 0.5891098 0.0182730849 1.198425e-01 2.197617e-01 10 69011202 69011300 99 + 0.287 0.000 -11.325
ENSG00000198954 E021 0.5180316 0.0206279138 2.744297e-02 6.689137e-02 10 69015358 69015436 79 + 0.000 0.373 11.173
ENSG00000198954 E022 920.7927886 0.0037920322 2.319789e-07 2.196837e-06 10 69015541 69016982 1442 + 2.895 3.034 0.463
ENSG00000198954 E023 1.1855894 0.3387183908 8.757039e-02 1.714475e-01 10 69041564 69042006 443 + 0.091 0.530 3.349
ENSG00000198954 E024 0.6653823 0.0172671820 6.414817e-01 7.545153e-01 10 69042007 69042141 135 + 0.231 0.162 -0.628
ENSG00000198954 E025 6.3503460 0.0122381881 1.979026e-04 9.548468e-04 10 69042142 69043544 1403 + 0.580 1.106 2.067