ENSG00000198951

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396398 ENSG00000198951 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGA protein_coding protein_coding 31.81769 41.33998 25.69102 2.273868 0.8867549 -0.686061 13.657767 17.536506 9.930813 1.18591003 0.3450994 -0.8197480 0.42746667 0.4239333 0.38723333 -0.036700000 5.287667e-01 4.977194e-07 FALSE  
ENST00000402937 ENSG00000198951 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGA protein_coding protein_coding 31.81769 41.33998 25.69102 2.273868 0.8867549 -0.686061 9.672614 12.932847 7.348411 0.62369258 0.9829988 -0.8146888 0.30762500 0.3130667 0.28496667 -0.028100000 7.705826e-01 4.977194e-07 FALSE  
ENST00000403363 ENSG00000198951 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGA protein_coding protein_coding 31.81769 41.33998 25.69102 2.273868 0.8867549 -0.686061 5.129140 7.651244 4.697396 0.35054143 0.6338631 -0.7026494 0.15533333 0.1859333 0.18336667 -0.002566667 9.826145e-01 4.977194e-07 FALSE  
MSTRG.22244.3 ENSG00000198951 HEK293_OSMI2_2hA HEK293_TMG_2hB NAGA protein_coding   31.81769 41.33998 25.69102 2.273868 0.8867549 -0.686061 1.547029 1.063496 2.040309 0.08840001 0.1608545 0.9335250 0.05297083 0.0259000 0.07946667 0.053566667 4.977194e-07 4.977194e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198951 E001 2.1714200 0.0072438620 1.522248e-01 2.647096e-01 22 42032649 42032697 49 - 0.619 0.382 -1.168
ENSG00000198951 E002 3.4978417 0.0045048648 4.132100e-01 5.567322e-01 22 42032698 42032764 67 - 0.705 0.581 -0.531
ENSG00000198951 E003 12.6501641 0.0104753565 5.281019e-04 2.264738e-03 22 42052650 42052769 120 - 1.310 0.954 -1.282
ENSG00000198951 E004 16.0304616 0.0286372146 6.274655e-05 3.449049e-04 22 42052770 42052956 187 - 1.456 0.998 -1.624
ENSG00000198951 E005 518.8638878 0.0001850834 3.666320e-02 8.483339e-02 22 42058334 42059795 1462 - 2.652 2.688 0.122
ENSG00000198951 E006 76.5524628 0.0003818897 7.640015e-01 8.471829e-01 22 42059796 42059801 6 - 1.860 1.848 -0.041
ENSG00000198951 E007 113.5483886 0.0003277013 4.301190e-01 5.727634e-01 22 42059802 42059838 37 - 2.002 2.031 0.098
ENSG00000198951 E008 144.7030263 0.0030535696 2.498664e-01 3.857492e-01 22 42059839 42059878 40 - 2.090 2.140 0.167
ENSG00000198951 E009 363.9659449 0.0002278429 1.385949e-04 6.974181e-04 22 42059879 42060019 141 - 2.466 2.546 0.267
ENSG00000198951 E010 304.6561172 0.0014516214 1.575546e-05 1.000511e-04 22 42060020 42060081 62 - 2.356 2.480 0.416
ENSG00000198951 E011 550.2393893 0.0001897698 7.511997e-05 4.048145e-04 22 42060082 42060413 332 - 2.653 2.720 0.224
ENSG00000198951 E012 287.2549591 0.0016869991 8.284148e-01 8.921900e-01 22 42060924 42061022 99 - 2.414 2.422 0.028
ENSG00000198951 E013 195.0049422 0.0051459294 6.237492e-01 7.402451e-01 22 42061023 42061067 45 - 2.237 2.259 0.073
ENSG00000198951 E014 369.8700413 0.0015039699 9.409301e-01 9.668510e-01 22 42062827 42063024 198 - 2.526 2.530 0.014
ENSG00000198951 E015 287.2554836 0.0001964062 4.087007e-01 5.523171e-01 22 42065738 42065899 162 - 2.430 2.413 -0.059
ENSG00000198951 E016 217.4930855 0.0002459781 2.580732e-01 3.952753e-01 22 42066710 42066804 95 - 2.319 2.291 -0.094
ENSG00000198951 E017 311.0399101 0.0001821320 1.365018e-04 6.880000e-04 22 42067113 42067290 178 - 2.509 2.430 -0.265
ENSG00000198951 E018 305.5618151 0.0001960733 2.342055e-07 2.215928e-06 22 42067765 42067936 172 - 2.521 2.413 -0.362
ENSG00000198951 E019 245.9447241 0.0002361479 1.635204e-02 4.350050e-02 22 42068439 42068574 136 - 2.394 2.337 -0.189
ENSG00000198951 E020 181.9106211 0.0002703056 9.003898e-02 1.751943e-01 22 42070282 42070366 85 - 2.254 2.207 -0.156
ENSG00000198951 E021 96.2760730 0.0005974961 3.301610e-01 4.737481e-01 22 42070367 42070373 7 - 1.973 1.936 -0.124
ENSG00000198951 E022 238.6001288 0.0055383649 7.017288e-01 8.007687e-01 22 42070374 42070762 389 - 2.349 2.337 -0.038
ENSG00000198951 E023 72.2396965 0.0028474723 6.191560e-01 7.366391e-01 22 42070763 42070776 14 - 1.840 1.816 -0.080
ENSG00000198951 E024 45.3805234 0.0099466466 1.844170e-02 4.810239e-02 22 42070777 42070807 31 - 1.734 1.568 -0.565
ENSG00000198951 E025 1.6532867 0.0093487182 3.103213e-01 4.527035e-01 22 42070808 42070842 35 - 0.513 0.337 -0.946
ENSG00000198951 E026 0.2955422 0.0293300111 6.310241e-01   22 42071084 42071393 310 - 0.162 0.091 -0.949