ENSG00000198945

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361794 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding protein_coding 3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 0.62773711 0.58525395 0.50519320 0.12061891 0.31297504 -0.2083917 0.24934167 0.40996667 0.104033333 -0.30593333 2.608435e-01 6.496676e-07 FALSE TRUE
ENST00000526019 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding protein_coding 3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 0.07382811 0.13016559 0.04308970 0.13016559 0.04308970 -1.4006283 0.03111667 0.09443333 0.007466667 -0.08696667 7.877358e-01 6.496676e-07 FALSE TRUE
ENST00000528385 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding protein_coding 3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 0.60371972 0.00000000 1.41173000 0.00000000 0.37299422 7.1515037 0.10350000 0.00000000 0.267800000 0.26780000 6.496676e-07 6.496676e-07 FALSE FALSE
ENST00000531313 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding retained_intron 3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 0.26387741 0.03326254 0.07290311 0.03326254 0.07290311 0.9383079 0.07948750 0.02413333 0.012633333 -0.01150000 8.377602e-01 6.496676e-07   FALSE
ENST00000533560 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding protein_coding 3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 1.75149729 0.55416417 3.06923077 0.28063717 0.21859051 2.4483830 0.43965000 0.36330000 0.598400000 0.23510000 6.642858e-01 6.496676e-07 FALSE TRUE
MSTRG.28955.6 ENSG00000198945 HEK293_OSMI2_2hA HEK293_TMG_2hB L3MBTL3 protein_coding   3.662674 1.494732 5.149254 0.177102 0.309882 1.777656 0.20704055 0.11915939 0.00000000 0.11915939 0.00000000 -3.6910807 0.06802083 0.06466667 0.000000000 -0.06466667 5.177154e-01 6.496676e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198945 E001 0.0000000       6 130013699 130013720 22 +      
ENSG00000198945 E002 0.0000000       6 130016226 130016292 67 +      
ENSG00000198945 E003 0.2998086 0.0297411463 0.4822658020   6 130018369 130018580 212 + 0.077 0.189 1.489
ENSG00000198945 E004 0.2998086 0.0297411463 0.4822658020   6 130018581 130018582 2 + 0.077 0.189 1.489
ENSG00000198945 E005 0.2998086 0.0297411463 0.4822658020   6 130018583 130018588 6 + 0.077 0.189 1.489
ENSG00000198945 E006 5.4013612 0.0034635175 0.8815766683 0.928112872 6 130018589 130018664 76 + 0.767 0.772 0.018
ENSG00000198945 E007 0.0000000       6 130019367 130019398 32 +      
ENSG00000198945 E008 1.2586448 0.0222100383 0.3101325305 0.452501329 6 130019399 130019463 65 + 0.373 0.189 -1.313
ENSG00000198945 E009 0.3686942 0.0271570586 0.4822158805 0.620377791 6 130020491 130020519 29 + 0.077 0.189 1.495
ENSG00000198945 E010 0.5169874 0.0212516451 0.1639750855 0.280313190 6 130020520 130020556 37 + 0.077 0.321 2.492
ENSG00000198945 E011 0.9640450 0.0154011111 0.2540148277 0.390654201 6 130020557 130020668 112 + 0.199 0.421 1.491
ENSG00000198945 E012 15.5876071 0.0011684992 0.0454632876 0.101045114 6 130022227 130022305 79 + 1.223 1.056 -0.600
ENSG00000198945 E013 23.5644357 0.0007738500 0.0235631252 0.058913100 6 130042685 130042801 117 + 1.392 1.240 -0.532
ENSG00000198945 E014 24.9440125 0.0008814096 0.0404620312 0.091870638 6 130049282 130049393 112 + 1.409 1.279 -0.452
ENSG00000198945 E015 0.0000000       6 130049651 130049755 105 +      
ENSG00000198945 E016 6.3580088 0.0026213097 0.2319953100 0.364822364 6 130049756 130049830 75 + 0.869 0.730 -0.552
ENSG00000198945 E017 28.1718337 0.0030626520 0.0906110873 0.176088615 6 130051249 130051408 160 + 1.447 1.349 -0.337
ENSG00000198945 E018 33.2575139 0.0006302521 0.0006317748 0.002650013 6 130052859 130052991 133 + 1.546 1.337 -0.719
ENSG00000198945 E019 1.0350216 0.0480235901 0.9612376719 0.979583760 6 130055087 130055170 84 + 0.294 0.319 0.162
ENSG00000198945 E020 21.5568599 0.0009478369 0.0464196869 0.102793310 6 130055171 130055255 85 + 1.349 1.212 -0.481
ENSG00000198945 E021 17.6595738 0.0018047726 0.1240113629 0.225695820 6 130057406 130057497 92 + 1.262 1.149 -0.398
ENSG00000198945 E022 19.8135990 0.0096475644 0.8740025734 0.923021138 6 130060036 130060140 105 + 1.262 1.306 0.154
ENSG00000198945 E023 24.9058531 0.0011643128 0.9485696834 0.971770461 6 130066353 130066488 136 + 1.364 1.389 0.086
ENSG00000198945 E024 24.8066397 0.0008534666 0.5414602132 0.672444282 6 130068330 130068421 92 + 1.375 1.359 -0.056
ENSG00000198945 E025 0.0000000       6 130070847 130070975 129 +      
ENSG00000198945 E026 26.2225589 0.0007651403 0.9415873068 0.967284970 6 130070976 130071127 152 + 1.382 1.417 0.121
ENSG00000198945 E027 16.1239683 0.0010747630 0.8548144911 0.910190708 6 130078558 130078634 77 + 1.181 1.226 0.160
ENSG00000198945 E028 14.7631295 0.0012559796 0.6496939168 0.760867942 6 130083620 130083705 86 + 1.164 1.149 -0.052
ENSG00000198945 E029 20.6593749 0.0167445849 0.4819040182 0.620094483 6 130086140 130086250 111 + 1.262 1.362 0.348
ENSG00000198945 E030 22.7875563 0.0009905292 0.4030513607 0.546847556 6 130092745 130092859 115 + 1.306 1.398 0.323
ENSG00000198945 E031 23.4374358 0.0010045170 0.7947067877 0.868857835 6 130094265 130094367 103 + 1.330 1.379 0.171
ENSG00000198945 E032 23.9757752 0.0012678053 0.1745105663 0.294067185 6 130104426 130104575 150 + 1.314 1.443 0.449
ENSG00000198945 E033 22.0603484 0.0032847070 0.9453651701 0.969693630 6 130120879 130120958 80 + 1.314 1.348 0.121
ENSG00000198945 E034 31.3614176 0.0012452624 0.4032572290 0.547040681 6 130133452 130133621 170 + 1.444 1.528 0.291
ENSG00000198945 E035 23.7590824 0.0008354078 0.8576697975 0.912103166 6 130133843 130133905 63 + 1.353 1.369 0.055
ENSG00000198945 E036 96.3974335 0.0244358177 0.0076134334 0.022807434 6 130139610 130141449 1840 + 1.868 2.099 0.776