ENSG00000198933

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361722 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding protein_coding 11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 2.0204270 1.9969193 1.6633193 0.3269050 0.1829505 -0.2622699 0.18522083 0.12203333 0.2022000 0.08016667 0.04083958 0.04083958 FALSE TRUE
ENST00000537587 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding protein_coding 11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 0.9240509 0.5619994 1.3166307 0.5619994 0.6730824 1.2136812 0.11111667 0.03320000 0.1494667 0.11626667 0.45485717 0.04083958 FALSE FALSE
ENST00000578982 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding protein_coding 11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 3.1932639 5.6183354 1.4908141 0.7018912 0.1927656 -1.9069630 0.26679583 0.34366667 0.1886333 -0.15503333 0.06978254 0.04083958 FALSE TRUE
ENST00000622396 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding protein_coding 11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 3.3945572 4.6865149 2.0590207 1.1035510 0.2324435 -1.1826425 0.29203333 0.29456667 0.2557333 -0.03883333 0.92088804 0.04083958 FALSE TRUE
MSTRG.14554.1 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding   11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 0.6696678 1.7560808 0.8097225 0.3693976 0.2026059 -1.1073438 0.05501667 0.10676667 0.1016667 -0.00510000 0.95560964 0.04083958 FALSE TRUE
MSTRG.14554.3 ENSG00000198933 HEK293_OSMI2_2hA HEK293_TMG_2hB TBKBP1 protein_coding   11.22197 16.24267 8.185152 0.668687 0.6461323 -0.9878343 0.6065090 0.6704696 0.5763913 0.3022041 0.2001093 -0.2146671 0.05629583 0.04013333 0.0683000 0.02816667 0.60633978 0.04083958 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198933 E001 5.560544 0.0088326682 9.213226e-01 9.543279e-01 17 47694063 47694103 41 + 0.772 0.775 0.009
ENSG00000198933 E002 14.436565 0.0285142599 2.744557e-01 4.136091e-01 17 47694161 47694194 34 + 1.015 1.180 0.598
ENSG00000198933 E003 8.574876 0.0040238472 2.641217e-03 9.194442e-03 17 47694508 47694558 51 + 1.140 0.820 -1.191
ENSG00000198933 E004 12.964416 0.0490263181 2.429266e-02 6.041895e-02 17 47694559 47694618 60 + 1.283 1.003 -1.005
ENSG00000198933 E005 14.483134 0.0212278386 1.490333e-01 2.603662e-01 17 47694619 47694663 45 + 1.236 1.096 -0.501
ENSG00000198933 E006 52.862490 0.0121530785 2.534431e-03 8.866693e-03 17 47695264 47695684 421 + 1.810 1.613 -0.668
ENSG00000198933 E007 49.627206 0.0015177271 1.074061e-05 7.086851e-05 17 47695685 47696078 394 + 1.792 1.576 -0.734
ENSG00000198933 E008 125.440304 0.0086055521 2.090069e-02 5.338007e-02 17 47696079 47696337 259 + 2.120 2.018 -0.344
ENSG00000198933 E009 95.097662 0.0003112921 6.285840e-03 1.936157e-02 17 47696711 47696833 123 + 1.986 1.901 -0.287
ENSG00000198933 E010 98.452877 0.0003391501 4.018647e-01 5.455619e-01 17 47697089 47697193 105 + 1.947 1.934 -0.044
ENSG00000198933 E011 76.066052 0.0004049122 1.041532e-01 1.968230e-01 17 47698595 47698691 97 + 1.756 1.850 0.316
ENSG00000198933 E012 72.167443 0.0004529647 4.270583e-03 1.390119e-02 17 47698692 47698775 84 + 1.683 1.841 0.533
ENSG00000198933 E013 31.341088 0.0105014555 1.484717e-01 2.595963e-01 17 47699320 47699322 3 + 1.336 1.484 0.512
ENSG00000198933 E014 96.862788 0.0003452381 8.003176e-02 1.596044e-01 17 47699323 47699495 173 + 1.865 1.955 0.303
ENSG00000198933 E015 58.957698 0.0004390689 2.703390e-01 4.089636e-01 17 47699636 47699697 62 + 1.665 1.741 0.257
ENSG00000198933 E016 40.217676 0.0076019200 6.379129e-01 7.516992e-01 17 47708394 47708512 119 + 1.518 1.574 0.192
ENSG00000198933 E017 77.911217 0.0246720838 1.145188e-01 2.121410e-01 17 47708725 47709413 689 + 1.909 1.811 -0.330
ENSG00000198933 E018 50.876062 0.0169386036 4.954164e-01 6.322235e-01 17 47709414 47709452 39 + 1.683 1.649 -0.114
ENSG00000198933 E019 617.025474 0.0097664156 1.405238e-02 3.834339e-02 17 47710498 47712052 1555 + 2.656 2.763 0.354