ENSG00000198924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361384 ENSG00000198924 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLRE1A protein_coding protein_coding 9.601407 1.893272 16.66701 0.1162065 0.6247378 3.131307 1.4445441 0.2878043 2.844113 0.11294288 0.1045438 3.260606 0.1411000 0.1480667 0.17070000 0.02263333 0.853736009 0.003145664 FALSE  
ENST00000369305 ENSG00000198924 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLRE1A protein_coding protein_coding 9.601407 1.893272 16.66701 0.1162065 0.6247378 3.131307 7.5894793 1.6054674 12.459991 0.08421369 0.7843706 2.948437 0.8128917 0.8519333 0.74626667 -0.10566667 0.364265924 0.003145664 FALSE  
ENST00000476112 ENSG00000198924 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLRE1A protein_coding processed_transcript 9.601407 1.893272 16.66701 0.1162065 0.6247378 3.131307 0.5673834 0.0000000 1.362903 0.00000000 0.3408533 7.101086 0.0460000 0.0000000 0.08303333 0.08303333 0.003145664 0.003145664    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198924 E001 0.3299976 0.0274424043 7.453683e-03   10 113834725 113834728 4 - 0.000 0.420 12.461
ENSG00000198924 E002 126.4330639 0.0004695676 1.474250e-17 7.067113e-16 10 113834729 113835312 584 - 1.911 2.206 0.989
ENSG00000198924 E003 83.3882061 0.0053191867 2.369690e-04 1.120590e-03 10 113837062 113837203 142 - 1.758 1.949 0.643
ENSG00000198924 E004 90.2868143 0.0003130640 5.796622e-03 1.807837e-02 10 113841406 113841560 155 - 1.807 1.921 0.382
ENSG00000198924 E005 93.9302567 0.0003569039 1.079470e-02 3.067337e-02 10 113842343 113842488 146 - 1.827 1.929 0.343
ENSG00000198924 E006 79.9919384 0.0003541483 1.789200e-01 2.997910e-01 10 113844104 113844244 141 - 1.768 1.821 0.179
ENSG00000198924 E007 55.4379389 0.0008580050 9.932726e-02 1.894643e-01 10 113845685 113845803 119 - 1.605 1.691 0.293
ENSG00000198924 E008 54.4420879 0.0004246605 1.572246e-02 4.211097e-02 10 113847202 113847335 134 - 1.589 1.719 0.441
ENSG00000198924 E009 379.8428814 0.0003664338 1.792957e-08 2.108837e-07 10 113848980 113850644 1665 - 2.469 2.315 -0.514
ENSG00000198924 E010 128.8937089 0.0017086986 4.371291e-10 6.918941e-09 10 113852723 113853242 520 - 2.023 1.669 -1.195
ENSG00000198924 E011 115.6199762 0.0352251872 1.615563e-03 6.010202e-03 10 113853243 113853847 605 - 1.974 1.638 -1.132
ENSG00000198924 E012 13.3981700 0.0013579893 4.759449e-02 1.048995e-01 10 113853848 113854082 235 - 1.071 0.770 -1.141
ENSG00000198924 E013 6.7665627 0.0024119661 1.540195e-01 2.671416e-01 10 113854239 113854353 115 - 0.810 0.537 -1.159
ENSG00000198924 E014 13.6716444 0.0062515982 1.786319e-02 4.684304e-02 10 113854354 113854383 30 - 1.086 0.705 -1.456