ENSG00000198919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361582 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding protein_coding 7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 3.0536133 0.00000000 7.5076020 0.00000000 0.34422352 9.554129 0.28717917 0.00000000 0.4974000 0.49740000 1.861990e-26 1.067487e-36 FALSE TRUE
ENST00000495008 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding nonsense_mediated_decay 7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 0.5626677 0.19901372 0.9150816 0.06067088 0.04978977 2.145983 0.08940417 0.09693333 0.0606000 -0.03633333 6.093144e-01 1.067487e-36 TRUE TRUE
MSTRG.23409.1 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding   7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 0.6741477 0.04683652 1.8812362 0.04683652 0.43994919 5.056368 0.06807917 0.01900000 0.1243000 0.10530000 3.447498e-02 1.067487e-36 FALSE TRUE
MSTRG.23409.2 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding   7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 1.5181205 0.81146028 2.4926161 0.19196416 0.24382261 1.607174 0.25432917 0.39033333 0.1646667 -0.22566667 3.266356e-02 1.067487e-36 FALSE TRUE
MSTRG.23409.3 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding   7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 0.5552649 0.93679319 0.0000000 0.14680321 0.00000000 -6.564977 0.14960000 0.44723333 0.0000000 -0.44723333 1.067487e-36 1.067487e-36 FALSE TRUE
MSTRG.23409.8 ENSG00000198919 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP3 protein_coding   7.562614 2.076817 15.09268 0.2031063 0.3500499 2.855429 0.4398942 0.00000000 1.2312917 0.00000000 0.16124306 6.955698 0.05679167 0.00000000 0.0817000 0.08170000 6.349052e-05 1.067487e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198919 E001 5.6541228 0.0027851618 3.347516e-02 7.872203e-02 3 108589693 108589694 2 + 0.719 0.285 -2.192
ENSG00000198919 E002 7.6180322 0.0021766757 3.982875e-02 9.071107e-02 3 108589695 108589704 10 + 0.820 0.455 -1.597
ENSG00000198919 E003 16.0475498 0.0010827015 2.235906e-02 5.642741e-02 3 108589705 108589721 17 + 1.099 0.817 -1.056
ENSG00000198919 E004 18.2607790 0.0009678714 6.221138e-03 1.919599e-02 3 108589722 108589733 12 + 1.154 0.817 -1.255
ENSG00000198919 E005 51.0230987 0.0019885187 4.005918e-07 3.611445e-06 3 108589734 108589839 106 + 1.584 1.145 -1.528
ENSG00000198919 E006 3.7119832 0.0249358413 1.692813e-01 2.872509e-01 3 108589857 108589937 81 + 0.573 0.285 -1.566
ENSG00000198919 E007 6.8152768 0.0095312667 1.432894e-02 3.897618e-02 3 108589938 108590054 117 + 0.788 0.285 -2.474
ENSG00000198919 E008 5.3382927 0.0191730375 4.935624e-02 1.080159e-01 3 108590055 108590096 42 + 0.699 0.285 -2.110
ENSG00000198919 E009 0.0000000       3 108602833 108602850 18 +      
ENSG00000198919 E010 0.1472490 0.0433840118 7.641744e-01   3 108602851 108602907 57 + 0.047 0.000 -7.112
ENSG00000198919 E011 0.5911862 0.0172671820 1.000000e+00 1.000000e+00 3 108603019 108603234 216 + 0.164 0.000 -9.112
ENSG00000198919 E012 56.3754753 0.0004437400 8.240674e-08 8.507280e-07 3 108605335 108605438 104 + 1.626 1.199 -1.478
ENSG00000198919 E013 40.3118336 0.0009226095 1.084050e-06 8.931463e-06 3 108608089 108608158 70 + 1.488 1.011 -1.683
ENSG00000198919 E014 53.6499274 0.0004589895 1.092336e-10 1.915400e-09 3 108611174 108611329 156 + 1.613 1.011 -2.112
ENSG00000198919 E015 49.0838251 0.0006060058 4.644483e-05 2.637066e-04 3 108616541 108616657 117 + 1.560 1.247 -1.084
ENSG00000198919 E016 39.8071441 0.0005454231 8.063979e-03 2.394208e-02 3 108624444 108624524 81 + 1.463 1.269 -0.671
ENSG00000198919 E017 42.6482059 0.0126025128 6.826651e-02 1.404970e-01 3 108625845 108625969 125 + 1.489 1.348 -0.489
ENSG00000198919 E018 50.2265131 0.0177546305 7.377196e-01 8.278153e-01 3 108629062 108629176 115 + 1.539 1.549 0.031
ENSG00000198919 E019 42.8856389 0.0218008448 5.941975e-01 7.164610e-01 3 108632953 108633072 120 + 1.476 1.461 -0.050
ENSG00000198919 E020 42.2332928 0.0339499531 5.667439e-01 6.936491e-01 3 108634871 108634958 88 + 1.468 1.452 -0.054
ENSG00000198919 E021 32.2564260 0.0712610532 4.499542e-01 5.911420e-01 3 108634959 108634972 14 + 1.361 1.300 -0.215
ENSG00000198919 E022 49.3085532 0.0021811148 4.805566e-02 1.057278e-01 3 108636616 108636708 93 + 1.544 1.431 -0.388
ENSG00000198919 E023 37.8756096 0.0005752195 1.417824e-01 2.504849e-01 3 108637496 108637548 53 + 1.429 1.348 -0.279
ENSG00000198919 E024 29.7656578 0.0007453510 1.236685e-01 2.251822e-01 3 108642438 108642514 77 + 1.330 1.224 -0.370
ENSG00000198919 E025 119.7228792 0.0004768818 3.091248e-04 1.416709e-03 3 108644164 108644730 567 + 1.925 1.787 -0.465
ENSG00000198919 E026 47.4955278 0.0086850749 1.121958e-01 2.087503e-01 3 108644731 108644781 51 + 1.528 1.431 -0.334
ENSG00000198919 E027 39.3853476 0.0061430155 2.460812e-01 3.813505e-01 3 108646617 108646649 33 + 1.444 1.384 -0.205
ENSG00000198919 E028 71.2404791 0.0017078212 1.010467e-03 3.994698e-03 3 108647943 108648112 170 + 1.708 1.524 -0.628
ENSG00000198919 E029 15.5680153 0.0013892086 2.634095e-01 4.013071e-01 3 108648113 108648917 805 + 1.026 1.199 0.626
ENSG00000198919 E030 40.8070059 0.0005299650 1.127791e-03 4.397220e-03 3 108648918 108648962 45 + 1.479 1.224 -0.889
ENSG00000198919 E031 40.3717353 0.0005170600 1.457292e-01 2.558401e-01 3 108651137 108651162 26 + 1.458 1.383 -0.257
ENSG00000198919 E032 79.9618833 0.0003599480 1.501757e-01 2.619060e-01 3 108654145 108654310 166 + 1.744 1.708 -0.123
ENSG00000198919 E033 66.2851402 0.0004140270 7.323244e-01 8.238029e-01 3 108661877 108661972 96 + 1.656 1.683 0.094
ENSG00000198919 E034 70.7370849 0.0003816327 2.037590e-01 3.309119e-01 3 108662130 108662257 128 + 1.688 1.658 -0.105
ENSG00000198919 E035 53.8501839 0.0004272887 5.110804e-01 6.461865e-01 3 108669681 108669749 69 + 1.567 1.570 0.009
ENSG00000198919 E036 60.2560826 0.0004388537 1.617930e-01 2.774618e-01 3 108672560 108672656 97 + 1.595 1.731 0.463
ENSG00000198919 E037 58.6771498 0.0004197501 1.994399e-02 5.137228e-02 3 108674078 108674181 104 + 1.575 1.767 0.650
ENSG00000198919 E038 56.6115668 0.0009505266 3.939670e-03 1.297226e-02 3 108675786 108675873 88 + 1.552 1.780 0.775
ENSG00000198919 E039 58.4947122 0.0120367645 2.232605e-01 3.542856e-01 3 108677497 108677598 102 + 1.580 1.734 0.522
ENSG00000198919 E040 64.9167570 0.0064981646 1.500770e-01 2.617774e-01 3 108684216 108684341 126 + 1.627 1.780 0.517
ENSG00000198919 E041 65.2218562 0.0138701212 6.145068e-01 7.329526e-01 3 108686445 108686584 140 + 1.639 1.736 0.332
ENSG00000198919 E042 70.6241208 0.0034315784 6.779184e-02 1.397022e-01 3 108687976 108688096 121 + 1.661 1.824 0.553
ENSG00000198919 E043 75.4739850 0.0009935444 2.572220e-02 6.336545e-02 3 108688593 108688736 144 + 1.685 1.859 0.588
ENSG00000198919 E044 72.0097905 0.0003772327 1.079073e-02 3.066484e-02 3 108688823 108688924 102 + 1.663 1.854 0.643
ENSG00000198919 E045 80.2167669 0.0012601343 1.985813e-04 9.577141e-04 3 108690787 108690903 117 + 1.698 1.945 0.831
ENSG00000198919 E046 12.0662434 0.0021560309 3.515916e-01 4.958385e-01 3 108690904 108691387 484 + 0.965 0.874 -0.344
ENSG00000198919 E047 241.7803135 0.0142736152 3.655567e-11 6.936461e-10 3 108693360 108694840 1481 + 2.126 2.561 1.455